Synthesis and anti-HIV activity of several 2′-fluoro-containing pyrimidine nucleosides was written by Sterzycki, Roman Z.; Ghazzouli, Ismail; Brankovan, Vera; Martin, John C.; Mansuri, Muzammil M.. And the article was included in Journal of Medicinal Chemistry on August 31,1990.Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:
Several 2′-fluoroarabino-2′,3′-dideoxy- and 2′-fluoro-2′,3′-unsaturated 2′,3′-dideoxy pyrimidine nucleoside analogs are reported. The saturated analogs 1-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)thymine or -uracil (I; R = Me or H, resp.) were readily prepared from the resp. 2′-deoxy-2′-fluoroarabinosyl nucleoside analog by radical deoxygenation of 3′-OH. The cytosine derivative II and the unsaturated compounds III and IV were also synthesized. The novel compounds were evaluated in vitro against human immunodeficiency virus (HIV) (LAV isolate). II was the most active of the newly synthesized substances against HIV with an ID50 of 0.8 μg/mL; ddC had an ID50 of 0.00m μg/mL. Because of its potency in the initial tests, II was further evaluated in both T cells and macrophage/monocyte cell lines, with several different isolates of HIV. Although II exhibited good antiviral activity in these systems, it was less active than AZT in these assays. At 1 μM the inhibition of CFU-GM by II was found to be 35-40%; this is slightly higher than seen with AZT. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3