Stone, K. John published an article in 1976, the title of the article was The role of tetrahydrofolate dehydrogenase in the hepatic supply of tetrahydrobiopterin in rats.Formula: C17H24N4O6 And the article contains the following content:
The reduction of 7,8-dihydrobiopterin (I) to 5,6,7,8-tetrahydrobiopterin by tetrahydrofolate dehydrogenase (EC 1.5.1.3) purified from rat liver was competitively inhibited by trimethoprim lactate (II) (0.36-50.mu.M, Ki 0.285.mu.M). The apparent Km for I was 430 times higher than that for dihydrofolate; reduction of I is thus more susceptible to inhibition by II than is dihydrofolate. I.p. administration of II had no effect on the hepatic supply of tetrahydrobiopterin in rats. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Formula: C17H24N4O6
The Article related to liver tetrahydrofolate dehydrogenase tetrahydrobiopterin, trimethoprim liver tetrahydrofolate dehydrogenase, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.Formula: C17H24N4O6
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia