Synthesis and antitumor activity of 2-alkanesulfinyl (or alkanesulfonyl)-7-methyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-ones was written by Suiko, Masahito;Maekawa, Kazuyuki. And the article was included in Agricultural and Biological Chemistry in 1977.Name: 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one The following contents are mentioned in the article:
The title compounds, I and II, were synthesized by m-chloroperbenzoic acid oxidation of the corresponding thioethers produced by coupling of alkylthio-thiadiazoles with Et acetoacetate. Compounds with electrophilic substituents, such as alkylsulfoxide or alkylsulfone, at the 2-position had a strong repressing effect on the propagation of Ehrlich ascites tumor cells. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Name: 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one).
5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Name: 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia