Suwal, Sujit; Rahman, Mahmuda; O’Brien, Gregory; Karambizi, Victoire G.; Wrotny, Matthew; Scott Goodman, M. published the artcile< Chemo-selective syntheses of N-t-boc-protected amino ester analogs through Buchwald-Hartwig amination>, Recommanded Product: Ethyl 2-chloropyrimidine-5-carboxylate, the main research area is amino ester preparation chemoselective; heterocyclic halo ester amine Buchwald Hartwig amination.
Synthesis of N-protected amino esters, e.g., I is achieved via a chemo-selective Buchwald Hartwig cross-coupling reaction using PEPPSI-IPr Pd-catalyst. Nearly two dozen functionally and structurally diverse mols. are created by individually cross-coupling eight II (R = Me, Et; Y = CH, N; X = Cl, Br) and three different secondary amines, e.g., tert-Bu piperazine-1-carboxylate. It was the observed that product formation is more facile in those heterocyclic esters II where nitrogen is present ortho to the halo substituent in the heteroaromatic ring. Based on this observation, a possible intermediate step in the cross-coupling cycle is proposed, where the nitrogen electron lone pair in the heterocycle may play an important role leading to a higher reaction yield.
New Journal of Chemistry published new progress about Amino esters Role: SPN (Synthetic Preparation), PREP (Preparation). 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, Recommanded Product: Ethyl 2-chloropyrimidine-5-carboxylate.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia