Tag: 100-200

In 2014,Rodriguez, Rodrigo A.; Pan, Chung-Mao; Yabe, Yuki; Kawamata, Yu; Eastgate, Martin D.; Baran, Phil S. published 《Palau’chlor: A Practical and Reactive Chlorinating Reagent》.Journal of the American Chemical Society published the findings.Product Details of 90213-66-4 The information in the text is summarized as follows:

Unlike its other halogen atom siblings, the utility of chlorinated arenes and (hetero)arenes are twofold: they are useful in tuning electronic structure as well as acting as points for diversification via cross-coupling. Herein we report the invention of a new guanidine-based chlorinating reagent I, CBMG or “”Palau’chlor””, inspired by a key chlorospirocyclization en route to pyrrole imidazole alkaloids. This direct, mild, operationally simple, and safe chlorinating method is compatible with a range of nitrogen-containing heterocycles as well as select classes of arenes, conjugated π-systems, sulfonamides, and silyl enol ethers. Comparisons with other known chlorinating reagents revealed CBMG to be the premier reagent. After reading the article, we found that the author used 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Product Details of 90213-66-4)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Product Details of 90213-66-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1984,Kazimierczuk, Zygmunt; Cottam, Howard B.; Revankar, Ganapathi R.; Robins, Roland K. published 《Synthesis of 2′-deoxytubercidin, 2′-deoxyadenosine, and related 2′-deoxynucleosides via a novel direct stereospecific sodium salt glycosylation procedure》.Journal of the American Chemical Society published the findings.Recommanded Product: 90213-66-4 The information in the text is summarized as follows:

A general and stereospecific synthesis has been developed for the direct preparation of 2′-deoxy-β-D-ribofurnaosylpurine analogs including 2′-deoxyadenosine derivatives The reaction of the Na salt of chloropyrrolo[2,3-d]pyrimidines I (R = H, Cl) with 1-chloro-2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranose (II) provided the corresponding N-1 2′-deoxy-β-D-ribofuranosyl blocked derivatives which, on ammonolysis, gave 2′-deoxytubercidin (III, R = H) and 2-chloro-2′-deoxyrubercidin (III, R = Cl), resp., in good yields. This glycosylation also readily proceeds in the presence of a 2-methylthio group. Application of this glycosylation procedure to 4,6-dichloroimidazo[4,5-c]pyridine, 6-chloropurine, 2,6-dichloropurine, and 4-chloropyrazolo[3,4-d]pyrimidine gave 2-chloro-2′-deoxy-3-deazaadenosine, 2′-deoxyadenosine, 2-chloro-2′-deoxyadenosine, and 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)pyrazolo[3,4-d]pyrimidine, resp. Similarly, glycosylation and ammonolysis of 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine gave 4,6-dichloro-1-(2-deoxy-β-D-erythro-pentofuranosyl)pyrrolo[3,2-c]pyridine. This stereospecific attachment of the 2-deoxy-β-D-ribofuranosyl moiety appears to be due to a Walden inversion at the C-1 carbon of II. The results came from multiple reactions, including the reaction of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Recommanded Product: 90213-66-4)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Recommanded Product: 90213-66-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1987,Biochemical and Clinical Aspects of Pteridines included an article by Huebsch, Walter. HPLC of Formula: 6297-80-9. The article was titled 《Synthesis and biological activity of 8-substituted thiolumazines》. The information in the text is summarized as follows:

I (X and Y = O or S, R = Me, CH2CH2OH, Ph, or ribityl were prepared as precursors and converted to thiolumazine derivatives II (X and Y = O or S, R = Me, CH2CH2OH, Ph, or ribityl, R1 and R2 = H, Me, OH, or Ph) were prepared and then structure-activity relation discussed with regard to enzyme inhibition in chemotherapy. The 2-oxo group was important for enzyme substrate interaction. Replacement by S had a strong neg. effect. In addition to this study using 4,6-Dichloropyrimidin-2(1H)-one, there are many other studies that have used 4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9HPLC of Formula: 6297-80-9) was used in this study.

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.HPLC of Formula: 6297-80-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Product Details of 6297-80-9On November 1, 2012 ,《Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Giordanetto, Fabrizio; Waallberg, Andreas; Ghosal, Saswati; Iliefski, Tommy; Cassel, Johan; Yuan, Zhong-Qing; von Wachenfeldt, Henrik; Andersen, Soeren M.; Inghardt, Tord; Tunek, Anders; Nylander, Sven. The article conveys some information:

Structure-based evolution of the original fragment leads resulted in the identification of 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, (S)-21, a potent, selective phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor with favorable in vivo antiplatelet effect. Despite its antiplatelet action, (S)-21 did not significantly increase bleeding time in dogs. Addnl., due to its enhanced selectivity over p110α, (S)-21 did not induce any insulin resistance in rats. In addition to this study using 4,6-Dichloropyrimidin-2(1H)-one, there are many other studies that have used 4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9Product Details of 6297-80-9) was used in this study.

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Product Details of 6297-80-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Synthesis and thermal transformations of 5-nitropyrimidin-4-yl dialkyldithiocarbamates》 was written by Ryabova, O. B.; Makarov, V. A.; Chernyshev, V. V.; Granik, V. G.. Application In Synthesis of 4-Chloro-6-methoxy-5-nitropyrimidine And the article was included in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) on April 30 ,2004. The article conveys some information:

On heating, 5-nitropyrimidin-4-yl dialkyldithiocarbamates undergo two types of transformations. One type of these transformations involves intramol. ipso-substitution of the nitro group to form bis(4-dialkylcarbamoylthiopyrimidin-5-yl) disulfides, whereas another type of transformations involves elimination of carbon disulfide to give 4,6-diamino-5-nitropyrimidine derivatives The reaction pathway is controlled by the steric effect of the substituent at position 6 of the pyrimidine ring.4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5Application In Synthesis of 4-Chloro-6-methoxy-5-nitropyrimidine) was used in this study.

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 4-Chloro-6-methoxy-5-nitropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ivanovskaya, L. Yu.; Derendyaev, B. G.; Baram, S. G. published an article on February 28 ,1982. The article was titled 《Mass spectra of pyrimidine derivatives. V. Methoxy- and dimethylaminopyrimidines》, and you may find the article in Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Khimicheskikh Nauk.Name: 2-Methoxy-5-nitropyrimidine The information in the text is summarized as follows:

The mass spectra of I (R = H, F, Cl), II (R = H, F; R1 = H, F, Cl), III, IV (R = F, Cl), V, and VI (R = H, Cl; R1 = H, Me, MeO, F, Cl, NO2) were analyzed. In the case of VI (R = H), electron-donating R1 substituents favored cleavage of a C-H bond in the OMe group, whereas electron-withdrawing R1 favored loss of CH2O. The experimental part of the paper was very detailed, including the reaction process of 2-Methoxy-5-nitropyrimidine(cas: 14001-69-5Name: 2-Methoxy-5-nitropyrimidine)

2-Methoxy-5-nitropyrimidine(cas: 14001-69-5) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Name: 2-Methoxy-5-nitropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Shafikov, Marsel Z.; Pander, Piotr; Zaytsev, Andrey V.; Daniels, Ruth; Martinscroft, Ross; Dias, Fernando B.; Williams, J. A. Gareth; Kozhevnikov, Valery N. published an article in 2021. The article was titled 《Extended ligand conjugation and dinuclearity as a route to efficient platinum-based near-infrared (NIR) triplet emitters and solution-processed NIR-OLEDs》, and you may find the article in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices.Related Products of 1193-21-1 The information in the text is summarized as follows:

Near IR (NIR) emission from mol. materials is typically targeted by using more extended conjugated systems compared to visible-emitting materials. But efficiencies usually fall off due to the combined effects of increasing non-radiative and lower oscillator strengths as the energy of emissive excited states decreases. Efficient NIR-emitting organic light emitting diodes (OLEDs) are rare compared to the huge progress that has been made for visible-light devices. For organometallic emitters that contain a heavy metal ion to promote phosphorescence through the effect of enhanced spin-orbit coupling (SOC), the problem is typically exacerbated by decreased metal character in the Sn and T1 excited states as the conjugation in a bound ligand increases. Here we show how the use of a dinuclear metal complex with an extended conjugated ligand allows such effects to be mitigated compared to analogous structures with just one metal center. The complex Pt2(bis-dthpym)(dpm)2 (complex 5) is readily prepared by a double NĈ cyclometallation of 4,6-bis(dithienyl)-pyrimidine (H2bis-dthpym), with the coordination sphere of each Pt center being completed by OÔ-coordinating dipivaloylmethane (dpm). This new complex displays intense NIR emission in solution, λmax = 725 nm, with essentially no “”contamination”” by visible light <700 nm. The photoluminescence quantum yield of 0.17 in toluene at 300 K is vastly superior to that of the analogous mononuclear complex, where reduced SOC leads primarily to ligand-based fluorescence and only very weak phosphorescence. Computational results indicate that a key reason for the superior performance of the dinuclear system is a doubling of the number of higher-lying excited singlet states with which the T1 state may couple, to promote the formally forbidden phosphorescence process. Complex 5 has been evaluated as an NIR emitter in solution-processed OLEDs. An external quantum efficiency (EQE) of 3.6% is attained using 5 doped into TBP:PBD at 5% weight/weight, with a turn-on voltage of 5.6 V (at 0.01 mW cm-2). The maximum radiosity of 2.7 mW cm-2 for this device is particularly high compared to most reported NIR-emitting phosphorescent OLEDs.4,6-Dichloropyrimidine(cas: 1193-21-1Related Products of 1193-21-1) was used in this study.

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Related Products of 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Optimization of the carbazole-pyrimidine linking pattern for achieving efficient TADF》 was published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2020. These research results belong to Serevicius, Tomas; Dodonova, Jelena; Skaisgiris, Rokas; Banevicius, Dovydas; Kazlauskas, Karolis; Jursenas, Saulius; Tumkevicius, Sigitas. Formula: C4H2Cl2N2 The article mentions the following:

A high fluorescence quantum yield is essential for achieving a high OLED efficiency. Due to their typically strong charge-transfer (CT) character, thermally activated delayed fluorescence (TADF) compounds usually have a lower prompt fluorescence efficiency, and therefore the boosting of the total emission yield (ϕPL) mostly relies on the enhancement of the delayed fluorescence efficiency. In this paper, we present a less frequently used approach for achieving a high ϕPL by maximising both prompt and delayed emission yields of carbazole-pyrimidine compounds Strong decoupling of HOMO and LUMO and the subsequent emergence of TADF were achieved by introducing four carbazole units at both meta positions of the Ph unit, though was low due to the prominent nonradiative triplet decay rate. Crowding the relatively loose carbazole units together at the para position and both meta positions, conversely, was shown to diminish the nonradiative decay, enhance the radiative decay rate and subsequently boost the fluorescence yield. Efficient blue electroluminescence with a nearly 20% yield was demonstrated for the optimized compound In the experiment, the researchers used many compounds, for example, 4,6-Dichloropyrimidine(cas: 1193-21-1Formula: C4H2Cl2N2)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Formula: C4H2Cl2N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Azoles and azines: CVII. Synthesis of 5H-pyrano[2,3-d:6,5-d’]dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetrones and their 2,8-dithio analogs》 was written by Moskvin, A. V.; Polkovnikova, I. I.; Ivin, B. A.. Formula: C5H6N2O3 And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) on August 31 ,1998. The article conveys some information:

5H-Pyrano[2,3-d:6,5-d’]dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetrones were prepared by treatment with a POCl3-P2O5 mixture of pyridinium salts of 5,5′-arylmethylenebisbarbituric acids or by condensation of 6-methoxyuracil with aromatic aldehydes or formaldehyde, followed by demethylation of intermediate 4,6-dimethoxy-5H-pyrano[2,3-d:6,5-d’]dipyrimidine-2,8(1H,9H)-diones. 2,8-Dithioxo-1,2,3,4,6,7,8,9-octahydro-5H-pyrano[2,3-d:6,5-d’]dipyrimidine-4,6-diones are formed by reaction of pyridinium salts of 5,5′-arylmethylenebis(2-thiobarbituric) acids with trifluoroacetic anhydride. After reading the article, we found that the author used 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Formula: C5H6N2O3)

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Formula: C5H6N2O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pander, Piotr; Zaytsev, Andrey V.; Sil, Amit; Williams, J. A. Gareth; Lanoe, Pierre-Henri; Kozhevnikov, Valery N.; Dias, Fernando B. published an article in 2021. The article was titled 《The role of dinuclearity in promoting thermally activated delayed fluorescence (TADF) in cyclometalated, N-C-N-coordinated platinum(II) complexes》, and you may find the article in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices.Related Products of 1193-21-1 The information in the text is summarized as follows:

We present the synthesis and in-depth photophys. anal. of a di-Pt(II) complex with a ditopic bis-N-C-N ligand. The complex exhibits a dual luminescent behavior by emitting simultaneously delayed fluorescence and phosphorescence. By comparing with the mono-Pt(II) analog, we demonstrate that thermally activated delayed fluorescence (TADF) is turned on in the di-Pt(II) complex due to the occurrence of three main differences relative to the mono-Pt(II) analog: a larger singlet radiative rate constant (kSr), a smaller singlet-triplet energy gap (ΔEST) and a longer phosphorescence decay lifetime (τPH). We observe similar trends among other di-Pt(II) complexes and conclude that bimetallic structures promote conditions favorable for TADF to occur. The diplatinum(II) complex also shows a long wavelength-emissive excimer which yields near IR electroluminescence, λel = 805 nm, in a solution-processed OLED device with EQEmax = 0.51%. We believe this is the highest efficiency reported to date for an excimer Pt(II) emitter with λel > 800 nm in a solution-processed OLED device.4,6-Dichloropyrimidine(cas: 1193-21-1Related Products of 1193-21-1) was used in this study.

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Related Products of 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia