Tag: 100-200

Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione《Synthesis of a novel fused tricyclic heterocycle, pyrimido[5,4-e][1,4]thiazepine, and its derivatives》 was published in 2013. The authors were Bazazan, Tahmineh;Bakavoli, Mehdi;Rahimizadeh, Mohammad;Eshghi, Hossein;Nikpour, Mohsen, and the article was included in《Heterocyclic Communications》. The author mentioned the following in the article:

Sequential treatment of 5-bromo-2,4-dichloro-6-(chloromethyl)pyrimidine with 2-aminothiophenol and secondary amines afforded a series of 2-[(5-bromo-2-chloro-6-aminopyrimidin-4-yl)methylthio]anilines. Reaction of the latter compounds with secondary amines in ethanol gave a family of new 5,11-dihydropyrimido[5,4-e][1,4]benzothiazepines I [R¹ = N(Et)₂, morpholinyl; R² = pyrrolidinyl, piperidinyl, 1-methylpiperazinyl, etc.]. And 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) was used in the research process.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Janietz, D.;Goldmann, B.;Rudorf, W. D. published 《Chloromethyl substituted heterocycles from methyl chlorotetrolate》. The research results were published in《Journal fuer Praktische Chemie (Leipzig)》 in 1988.Related Products of 18592-13-7 The article conveys some information:

Reaction of ClCH₂CCCO₂Me with RNHCR¹:NH (R = H, Ph, R¹ = SMe; R = H, R¹ = Ph, 4-O₂NC₆H₄) gave pyrimidones I which were hydrolyzed to the uracils. Thiazinones II (R² = H, Me, Et) were similarly prepared from R²NHCSNH₂ and were hydrolyzed to the diones. Isomeric chloromethylthiazolopyrimidinones were obtained from ClCH₂CCCO₂Me or ClCH₂COCH₂CO₂Et and aminothiazoles. An imidazothiazinone was similarly obtained from the mercaptoimidazole. And 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) was used in the research process.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Related Products of 18592-13-7) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Recommanded Product: 18592-13-7In 1989, Naguib, Fardos N. M.;El Kouni, Mahmoud H.;Cha, Sungman published 《Structure-activity relationship of ligands of dihydrouracil dehydrogenase from mouse liver》. 《Biochemical Pharmacology》published the findings. The article contains the following contents:

One hundred and five nucleobase analogs were screened as inhibitors of dihydrouracil dehydrogenase (DHUDase, EC 1.3.1.2) from mouse liver. 5-Benzyloxybenzyluracil, 1-deazauracil (2,6-pyridinediol), 3-deazauracil (2,4-pyridinediol), 5-benzyluracil, 5-nitrobarbituric acid and 5,6-dioxyuracil (alloxan) were identified as potent inhibitors of this activity, with apparent K_i values of 0.2, 0.5, 2.1, 3.4, 3.8 and 6.6 μM resp. Both 5-benzyloxybenzyluracil and 1-deazauracil were also potent inhibitors of DHUDase from human livers. These findings along with an extensive review of literature allowed the formulation of a structure-activity relationship. The binding to DHUDase required intact C2 and C4 oxo groups. Replacement of N1 or N3 by an endocyclic carbon enhanced binding. In contrast, replacement of C5 or C6 by an endocyclic nitrogen abolished binding. Addition of a charged group to C5 and/or C6, and of a hydrophobic group to C5 but not C6 improved the binding. To complete the study, the researchers used 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) .

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Recommanded Product: 18592-13-7) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Recommanded Product: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione《Molecular recognition of Langmuir-Blodgett polymer films containing uracil groups》 was published in 2008. The authors were Sugiyama, N.;Hirakawa, M.;Zhu, H.;Takeoka, Y.;Rikukawa, M., and the article was included in《Colloids and Surfaces, A: Physicochemical and Engineering Aspects》. The author mentioned the following in the article:

Novel copolymers, poly(acryroyloxymethyluracil-co-hexylacrylamide)s (poly(AU-co-HAAm)s), were synthesized by radical copolymerization with different monomer ratios. The poly(AU-co-HAAm)s formed stable monolayers at the air-water interface and could be deposited on solid substrates as Y-type films by the vertical dipping method. The mol. structure of poly(AU-co-HAAm) LB films was determined by reflection absorption and transmission FTIR, and x-ray diffraction measurements. Evidence for preferential orientation of both the AU and HAAm units was found. The LB films deposited on quartz crystal microbalance substrates adsorbed adenosine mols., and the adsorbed amounts increased with higher contents of uracil groups in poly(AU-co-HAAm)s. Some morphol. changes of LB films were also observed by at. force microscopy (AFM) after the mol. recognition.6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) were involved in the experimental procedure.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Recommanded Product: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Niedzwicki, John G.;Iltzsch, Max H.;El Kouni, Mahmoud H.;Cha, Sungman published 《Structure-activity relationship of pyrimidine base analogs as ligands of orotate phosphoribosyltransferase》 in 1984. The article was appeared in 《Biochemical Pharmacology》. They have made some progress in their research.Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione The article mentions the following:

Eighty pyrimidine base analogs were evaluated as inhibitors of mouse liver orotate phosphoribosyltransferase (I) (EC 2.4.2.10). Based on these findings and an extensive literature review, a structure-activity relation was formulated for the binding of pyrimidine base analogs to I. A basis for the rational design of new inhibitors of I is provided, and several such compounds are proposed. Addnl., 4,6-dihydroxypyrimidine was found to be a potent I inhibitor. Eleven I inhibitors were also evaluated as inhibitors of orotidine 5′-monophosphate decarboxylase (II) (EC 4.1.2.23). 5-Azauracil, 5-azaorotate, and barbituric acid inhibited II significantly after preincubation with PRPP and MgCl₂ in the presence of cytosol.6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) were involved in the experimental procedure.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hansen, Steen Uldall;Bols, Mikael published 《1-Azaribofuranoside analogs as designed inhibitors of purine nucleoside phosphorylase. Synthesis and biological evaluation》. The research results were published in《Acta Chemica Scandinavica》 in 1998.Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione The article conveys some information:

Pyrrolidine analogs of 2-deoxyribofuranose, having nitrogen in place of anomeric carbon, have been synthesized as potential transition state analogs of enzymic nucleoside cleavage. Efficient synthetic methods were developed that allowed the synthesis of a wide range of 4-substituted 3-hydroxypyrrolidines starting from pyrroline and using opening of the pyrrolidine 3,4-epoxide with carbon nucleophiles. Among the compounds synthesized were the 4-cyano-, 4-hydroxymethyl and 4-carboxymethyl derivatives From the hydroxymethyl derivative, N-alkylation with chloromethyluracil gave an inosine analog. The new compounds were tested for inhibition of human erythrocyte purine nucleoside phosphorylase. Furthermore, a solid-phase synthesis of 1′-azanucleoside analogs was developed.6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) were involved in the experimental procedure.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Crigg, Ronald;Myers, Peter;Somasunderam, Anoma;Sridharan, Visuvanathar published 《X:Y-ZH systems as potential 1,3-dipoles. Part 36. 1,5-Electrocyclization processes via oxidation of tertiary amines. Pyrrolodihydroisoquinolines and -dihydro-β-carbolines》. The research results were published in《Tetrahedron》 in 1992.Electric Literature of C5H5ClN2O2 The article conveys some information:

A range of tertiary N-allylamines, e.g. I, derived from 1,2,3,4-tetrahydroisoquinoline undergo oxidative cyclization induced by Ag₂CO₃ to give pyrrolodihydroisoquinolines, e.g., II, in moderate to good yield. Analogous oxidative cyclizations are reported for N-allyltetrahydro-β-carbolines and a pyrrolidine. The reactions proceed via formation of a 1,5-dipole followed by an electrocyclization and subsequent aromatization. And 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) was used in the research process.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Electric Literature of C5H5ClN2O2) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Liu, Houmei;Guo, Yong;Wang, Xusheng;Liang, Xiaojing;Liu, Xia;Jiang, Shengxiang published 《A novel fullerene oxide functionalized silica composite as stationary phase for high performance liquid chromatography》. The research results were published in《RSC Advances》 in 2014.SDS of cas: 18592-13-7 The article conveys some information:

Hydrophilic interaction liquid chromatog. has been widely used for separating hydrophilic compounds and the development of new stationary phases for HILIC is significant. In this study, fullerene oxide was successfully assembled onto silica microspheres to form a FO-modified silica stationary phase. The synthesized material was characterized by elemental anal., transmission electron microscopy, Raman spectroscopy and contact angle anal. The chromatog. properties of the stationary phase were investigated in HILIC mode for anal. of nucleosides, nucleobases, water soluble vitamins, amino acids and saccharides. Good separations of these compounds were achieved on the resulting column. Compared with the aminopropylated silica column, FO/SiO₂ column exhibited better separation efficiency. This study also investigated the effect of various exptl. factors on the retention of the polar stationary phases, such as acetonitrile content and salt concentration in the mobile phase.6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) were involved in the experimental procedure.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 SDS of cas: 18592-13-7) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Cusack, Lucy;Rao, S. Nagaraja;Fitzmaurice, Donald published 《Heterosupramolecular chemistry: self-assembly of an electron donor (TiO₂ nanocrystallite)-acceptor (viologen) complex》. The research results were published in《Chemistry – A European Journal》 in 1997.Related Products of 18592-13-7 The article conveys some information:

A TiO₂ nanocrystallite has been modified to recognize and selectively bind, by complementary hydrogen bonding, a uracil substrate incorporating a viologen moiety. Band-gap excitation of the self-assembled donor (TiO₂ nanocrystallite)-acceptor (viologen) complex results in electron transfer. Some implications of these findings for the self-assembly of functional nanostructures containing both condensed phase and mol. components are considered. To complete the study, the researchers used 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) .

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Related Products of 18592-13-7) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Wade, James J. published 《Synthesis of imidazo[1,5-c]pyrimidine derivatives》. The research results were published in《Journal of Heterocyclic Chemistry》 in 1986.Computed Properties of C5H5ClN2O2 The article conveys some information:

Two complementary procedures, each starting from 6-(aminomethyl)uracil (I), were used to prepare imidazopyrimidines II (R = H, Me, Pr, CHMe₂, CMe₃, Ph; R¹ = morpholino, OMe, SPr, Me). I was prepared by ammoxidation of 6-(chloromethyl)uracil. In the first procedure, I was acylated and then cyclodehydrated by reaction with POCl₃ to give a separable mixture of II and III (R¹ = Cl). The relative product distribution is subject to some control by the choice of the acyl substituent on the starting uracil. II (R¹ = Cl) were derivatized by reaction at the 5-position with various nucleophiles, although the 7-chloro substituent is unreactive. An alternative synthetic method proceeds from I in six steps, i.e. protection as the phthalimide, chlorination, nucleophilic substitution, deprotection, acylation, and cyclodehydration, to give II (R¹ = SMe). These compounds were also derivatized by nucleophilic substitution at the 5-position.6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) were involved in the experimental procedure.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Computed Properties of C5H5ClN2O2) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia