Tag: 100-200

Application In Synthesis of 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione《Some novel piperidine analogues having strong alpha glucosidase inhibition》 was published in 2018. The authors were Rafiq, Kiran;Saify, Zafar Saied;Nesar, Shagufta;Faiyaz, Ambreen;Muhammad, Iyad Naeem, and the article was included in《Pakistan Journal of Pharmaceutical Sciences》. The author mentioned the following in the article:

In the present work some hydroxy piperidine analogs have been synthesized and analyzed for their hypoglycemic effect through glucosidase inhibition owing to the structural resemblance with nojirimycin. The activity was done by spectral absorbance anal. using acarbose as standard Two analogs 1-(1”-phenoxypropyl)-4-phenyl-4-hydroxy piperidinium hydrobromide and 1-(1”-adamantan acyl)-4-(4′-bromophenyl)-4-hydroxy piperidinium hydrobromide were found to pose excellent activity having 87.4 and 54.7% inhibition resp., hence strengthening the idea of studying piperidine analogs as glucosidase inhibitors due to structural similarity with nojirimycin. The experimental procedure involved many compounds, such as 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) .

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Application In Synthesis of 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dioneIn 1999, Singh, Chatar;Singh, S.;Pandey, Seema;Tripathi, P. K. published 《Vibrational spectra of 6-chloromethyluracil》. 《Asian Chemistry Letters》published the findings. The article contains the following contents:

Laser Raman and IR spectra of 6-(chloromethyl)uracil (I) were recorded and analyzed on the basis of C_s point-group symmetry. The absence of any O-H stretching vibration and the appearance of C=O stretching modes as strong bends in the spectra of I suggest that no tautomerism occurs, and the compound exists in the ketone form. The experimental procedure involved many compounds, such as 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) .

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Reference of 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mather, Brian D.;Lizotte, Jeremy R.;Long, Timothy E. published 《Synthesis of Chain End Functionalized Multiple Hydrogen Bonded Polystyrenes and Poly(alkyl acrylates) Using Controlled Radical Polymerization》 in 2004. The article was appeared in 《Macromolecules》. They have made some progress in their research.Product Details of 18592-13-7 The article mentions the following:

Hydrogen bonding uracil functionalized polystyrenes and poly(alkyl acrylate)s were synthesized via stable free radical polymerization Quant. chain end functionalization was achieved using novel uracil containing TEMPO- and DEPN-based alkoxyamine unimol. initiators. Polymerizations were conducted at 130 °C and yielded functionalized homopolymers with narrow mol. weight distributions (M_w/M_n ∼ 1.20) and predictable mol. weights Polymerizations of both Bu acrylate and styrene using the DEPN- and TEMPO-based alkoxyamines resulted in mol. weight control over a wide range of conversions. Terminal functionalization of poly(alkyl acrylate)s with hydrogen bonding groups increased the melt viscosity at temperatures below 80 °C, which was defined as the dissociation temperature, and as expected, the viscosity approached that of the nonfunctional analogs above this temperature The hydrogen bonding effect was also evident in thermal (DSC) anal. and ¹H NMR spectroscopic investigations, and low molar mass polystyrenes exhibited glass transition temperatures that were consistent with a higher apparent molar mass. ¹H NMR spectroscopy confirmed the presence of a single hydrogen bonding group at the chain terminus, which was consistent with a well-defined initiation process for two families of novel alkoxyamines. And 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) was used in the research process.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Product Details of 18592-13-7) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia