Tag: 100-200

Easy synthesis of new series of pteridine analogs: di- and tetra-hydropyrimido[4,5-d]pyrimidines via 5-pyrimidinecarbaldehydes was written by de la Torre, Jose M.;Nogueras, Manuel;Borkowski, Eduardo J.;Suvire, Fernando D.;Enriz, Ricardo D.;Cobo, Justo. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2014.Quality Control of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one This article mentions the following:

Pyrimidine-5-carbaldehyde derivatives, of easy access, were selected as precursors for the synthesis of mimic pteridine derivatives 5,6-dihydropyrimido[4,5-d]pyrimidines I [R¹ = C₆H₅, CH₂C₆H₅, C₆H₁₁, CH(CH₃)C₆H₅; R² = H, CH₃; X = O, S] and 5,6,7,8- tetrahydropyrimido[4,5-d]pyrimidines II (R³ = H, CH₃, C₆H₅) via 4-amino-(5-aminomethyl)pyrimidine intermediates. Straightforward procedures allow a quick access to these compounds The dihydro derivatives were prepared means of a final cyclocondensation carried out with orthoesters R²R³C(O), catalyzed by acid and assisted by microwaves irradiation under solvent-free conditions. The final cyclocondensation with carbonyl compounds forming the tetrahydro derivatives was done under mild conditions, in which stereochem. induction was carried out on the building of this skeleton, and stereochem. assignments corroborated by theor. calculations In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Quality Control of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Quality Control of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A general asymmetric copper-catalysed Sonogashira C(sp³)-C(sp) coupling was written by Dong, Xiao-Yang;Zhang, Yu-Feng;Ma, Can-Liang;Gu, Qiang-Shuai;Wang, Fu-Li;Li, Zhong-Liang;Jiang, Sheng-Peng;Liu, Xin-Yuan. And the article was included in Nature Chemistry in 2019.Related Products of 37972-24-0 This article mentions the following:

Continued development of the Sonogashira coupling has made it a well established and versatile reaction for the straightforward formation of C-C bonds, forging the carbon skeletons of broadly useful functionalized mols. However, asym. Sonogashira coupling, particularly for C(sp³)-C(sp) bond formation, has remained largely unexplored. Here the authors demonstrate a general stereoconvergent Sonogashira C(sp³)-C(sp) cross-coupling of a broad range of terminal alkynes and racemic alkyl halides (>120 examples) that are enabled by copper-catalyzed radical-involved alkynylation using a chiral cinchona alkaloid-based P,N-ligand. Industrially relevant acetylene and propyne are successfully incorporated, laying the foundation for scalable and economic synthetic applications. The potential utility of this method is demonstrated in the facile synthesis of stereoenriched bioactive or functional mol. derivatives, medicinal compounds and natural products that feature a range of chiral C(sp³)-C(sp/sp²/sp³) bonds. This work emphasizes the importance of radical species for developing enantioconvergent transformations. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Related Products of 37972-24-0).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Related Products of 37972-24-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Efficient and convenient preparation of 3-aryl-2,2-dimethylpropanoates via Negishi coupling was written by Kwak, Young-Shin;Kanter, Aaron D.;Wang, Bing;Liu, Yugang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2009.HPLC of Formula: 62968-37-0 This article mentions the following:

An efficient and convenient Negishi coupling protocol was developed for the preparation of 3-aryl-2,2-dimethylpropanoates providing easy access to key pharmaceutical intermediates that often require multi-step synthesis using conventional enolate chem. In the experiment, the researchers used many compounds, for example, 4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0HPLC of Formula: 62968-37-0).

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.HPLC of Formula: 62968-37-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Heterocycles. 41. Preparation of substituted 3,4-dihydro-2(1H)-pyrimidinimines and 2-aminopyrimidines from guanidine and 浼?灏?unsaturated ketones was written by Wendelin, Winfried;Harler, Anton. And the article was included in Monatshefte fuer Chemie in 1975.Recommanded Product: 4,5-Dimethylpyrimidin-2-amine This article mentions the following:

HN:C(NH2)2 reacted with RCOCR1:CHR3[R = Me, Ph3R1 = H, Me; R2 = H, Me, Ph, or R1R2 = (CH2)9] to give the unstable dihydropyrimidinimines I, which dehydrogenated to give the corresponding 2-pyrimidinamines II. The unstable I[R = Ph, R1 = H, R2 = Me; R-R2 = Me; R = Me, R1R2 = (CH2)4] were isolated as the corresponding stable 1H-2-pyrimidinium and 1H-2-quinazolinium picrates, whereas I(R = R2 = Ph, R1 = H) was isolated as its hydrochloride. In the experiment, the researchers used many compounds, for example, 4,5-Dimethylpyrimidin-2-amine (cas: 1193-74-4Recommanded Product: 4,5-Dimethylpyrimidin-2-amine).

4,5-Dimethylpyrimidin-2-amine (cas: 1193-74-4) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 4,5-Dimethylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and herbicidal activity of 2-aminopyrimidines and their derivatives of 2-thiophenesulfonylureas was written by Xue, Si-Jia;Sun, Chang-You. And the article was included in Hecheng Huaxue in 1998.Application of 1193-74-4 This article mentions the following:

Using Claisen condensation six 灏?dicarbonyl compounds HCOR (R = CH₂COCH₃, CH(CH₃)COCH₃, CH₂COC₆H₅), PhCOCH₂COCH₃, EtCOCH(CH₃)COOEt, and 2-formylcyclohexanone were prepared and reacted with guanidine carbonate to give seven 2-aminopyrimidines I (X = CH₃, C₆H₅, OH, Cl; Y = H, C₆H₅, Et; Z = H, CH₃; XZ = (CH₂)₄). Five N’-(substituted pyrimidin-2-ly)-2-thiophenesulfonylureas II were prepared by nucleophilic addition of 2-aminopyrimidines I with 2-thiophenesulfonyl isocyanate. The structures of substituted 2-aminopyrimidines and their 2-thiophenesulfonylurea derivatives were confirmed by IR,¹H NMR and elemental anal., and their herbicidal activities were tested. In the experiment, the researchers used many compounds, for example, 4,5-Dimethylpyrimidin-2-amine (cas: 1193-74-4Application of 1193-74-4).

4,5-Dimethylpyrimidin-2-amine (cas: 1193-74-4) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Application of 1193-74-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Unfused heterobicycles as amplifiers of phleomycin. II. Some 2,4′-, 4,5′- and 5,5′-bipyrimidines was written by Brown, Desmond J.;Cowden, William B.;Strekowski, Lucjan. And the article was included in Australian Journal of Chemistry in 1981.Quality Control of 2-Chloropyrimidine-4-carbonitrile This article mentions the following:

Methoxy, methylthio, dimethylamino, 灏?dimethylaminoethylamino, and 灏?dimethylaminoethylthio substituted 2,4′-, 4,5′- and 5,5′-bipyrimidines were prepared Thus, the pyrimidine I (R = Cl, R¹ = CN) was treated with Me₂NH and the resulting I (R = Me₂N, R¹ = CN) treated with PhSO₃^–.NH₄⁺ to give I (R = Me₂N, R¹ = C(:NH)NH₂).PhSO₃H, which was cyclized with H₂C(CO₂Me)₂ to give the bipyrimidine II. II was chlorinated by POCl₃ and then treated with Me₂NH and Me₂NCH₂CH₂NH₂ to give the bipyrimidine III. In the experiment, the researchers used many compounds, for example, 2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4Quality Control of 2-Chloropyrimidine-4-carbonitrile).

2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Quality Control of 2-Chloropyrimidine-4-carbonitrile

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine derivatives. IV. 4 was written by Inoue, Shoji. And the article was included in Chemical & Pharmaceutical Bulletin in 1958.HPLC of Formula: 69785-94-0 This article mentions the following:

The 2,4-(HS)₂ derivative of 5-nitropyrimidine (I) (2 g.) (cf. Part II) in 40 cc. N NaOH reduced by stirring with Na₂S₂O₄ until the red color disappeared and then warmed 15 min. at 50鎺?yielded 1.2 g. 2,4-(HS)₂ derivative (II) of 5-aminopyrimidine (III), decompose above 270鎺? tri-Ac derivative, m. above 300鎺? II (2 g.) refluxed 5 hrs. on an oil bath with 60 cc. Ac₂O, excess reagent removed in vacuo, and the residue extracted with ether cyclized to 2 g. 2,5-Me(AcS) derivative of thiazolo[5,4-d]pyrimidine (IV), m. 135鎺? Hydrolysis of the residue from another 2 g. II with 10% NaOH in place of ether and acidification of the filtrate yielded 1.5 g. 2,5-Me(HS) derivative (V) of IV, decompose above 242鎺? identified as the 2,5-Me(EtS) derivative (VI) of IV, m. 56鎺?(from KOH and EtBr on V, identical with VIII of Part III). V (0.65 g.) in 20 cc. H₂O catalytically desulfurized by refluxing 3 hrs. with 5 g. Raney Ni in 5 cc. 25% NH₄OH and the concentrated filtrate from the mixture extracted with ether gave the 2-Me derivative of IV, m. 76-7鎺? II (1 g.) in 20 cc. C₅H₅N treated slowly with 8 cc. BzCl precipitated the tri-Bz derivative, but refluxing the mixture 3 hrs. in an oil bath, pouring on ice, and making alk. gave 2 g. 2,5-Ph(BzS) derivative of IV, m. 180-1鎺? which was hydrolyzed by heating 2-3 hrs. on a water bath with N NAOH, filtering, and acidifying to give 2,5-Ph(HS) derivative of IV, identified as was V by the 2,5-Ph(EtS) derivative of IV, m. 131鎺? or the 2,5-Ph(PhCH₂S) derivative of IV, m. 184鎺? II (0.5 g.) refluxed 15 hrs. with K methylxanthate (from 0.6 g. KOH in 4 cc. H₂O and 20 cc. MeOH shaken with 0.64 g. CS₂) and the mixture acidified gave crude 2,5-(HS)₂ derivative of IV, isolated and purified as the 2,5-(EtS)₂ derivative of IV (as was V), m. 69鎺? The 2,4-EtS(HO) derivative of III, prepared according to Boarland and McOmie (C.A. 48, 2072f), the H₂N group acylated to HCONH (or AcNH), the product refluxed 5 hrs. in an oil bath with 1.5 g. P₂S₅ and 10 cc. xylene, cooled, the solid left standing with 30 cc. 5% NH₄OH, and then extracted with ether gave the 5-EtS derivative of IV, m. 82鎺?[or the 2,5-Me(EtS) derivative of IV, m. 56鎺? identical with VI]. These last 2 ring closures probably proceed through the intermediate 2,4,5-EtS(HS)(RCSNH) derivative of pyrimidine by the liberation of H₂S. In the experiment, the researchers used many compounds, for example, 5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0HPLC of Formula: 69785-94-0).

5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.HPLC of Formula: 69785-94-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and biological evaluations of new pyrazole hydrazides as potent anti-microbial agent was written by S., Gunasekar;M., Saamanthi;S., Aruna. And the article was included in Materials Today: Proceedings in 2021.Application In Synthesis of 2-Methoxypyrimidine-5-carbaldehyde This article mentions the following:

A sequence of pyrazole hydrazides I (R = 4-methoxy-2,3-dimethylphenyl, 6-chloropyridin-3-yl, 2-methoxypyrimidin-5-yl, 4-(benzyloxy)benzen-1-yl, etc.) was synthesized I (R = 4-methoxy-2,3-dimethylphenyl), and its anti-microbial activities were studied for its in vitro anti-microbial activities against staphylococcus aureus and Escherichia coli and found almost all synthesized mols. I are active. Also synthesized mols. were ascertained by ¹H NMR, ¹³C NMR and mass spectroscopy and pyrazole hydrazide I was synthesized by dehydration reaction of N-(5-[(hydrazinecarbonyl)methyl]-1H-pyrazol-3-yl)-4-(trifluoromethyl)benzamide with different aldehydes RCHO. All the reaction progress were monitored by TLC. Min. inhibition values of synthesized mols. were studied using Staphylococcus aureus and Escherichia coli and some of the compounds show good MIC values such as I (R = 2,3-dichlorophenyl (24), 6-chloropyridin-3-yl (23), 2-methoxypyrimidin-5-yl (23)) as compared to existing drug cefotaxime. In the experiment, the researchers used many compounds, for example, 2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1Application In Synthesis of 2-Methoxypyrimidine-5-carbaldehyde).

2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Application In Synthesis of 2-Methoxypyrimidine-5-carbaldehyde

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

5-(2-Hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-3-methyl-2-(methylsulfanyl)-6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one monohydrate: complex sheets generated by multiple hydrogen bonds was written by Cruz, Silvia;Quiroga, Jairo;de la Torre, Jose M.;Cobo, Justo;Low, John N.;Glidewell, Christopher. And the article was included in Acta Crystallographica, Section C: Crystal Structure Communications in 2006.Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one This article mentions the following:

In 5-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-3-methyl-2-(methylsulfanyl)-6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one monohydrate, C₂₂H₂₃N₃O₃S璺疕₂O, the nonaromatic carbocyclic ring adopts a half-chair conformation. The mols. are linked into complex sheets by a combination of 1 N-H璺矾璺疧 H bond and 3 O-H璺矾璺疧 H bonds. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Photoelectron spectra and electronic structures of substituted pyrimidines was written by Lottermoser, Ursula;Rademacher, Paul;Mazik, Monika;Kowski, Klaus. And the article was included in European Journal of Organic Chemistry in 2005.Related Products of 37972-24-0 This article mentions the following:

The electronic structures of pyrimidine and its substituted derivatives were studied by UPS and quantum chem. methods. The ionization potentials corresponding to the 锜?MOs 锜?sub>1-锜?sub>3 and the two n_N orbitals of the pyrimidine unit could be determined and assigned for all compounds Multiple linear regression analyses of the IPs related to these orbitals with different substituent constants indicated that Hammett 锜?sub>P values performed well for all these IPs, whereas the resonance parameters R and R⁺ were satisfactory for 锜?and poor for n_N ionizations. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Related Products of 37972-24-0).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Related Products of 37972-24-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia