Tag: 200-300

Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides was written by Kanagarajan, V.;Thanusu, J.;Gopalakrishnan, M.. And the article was included in European Journal of Medicinal Chemistry in 2010.Formula: C16H13N3 This article mentions the following:

Biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides I (R¹ = H, F, Me; R² = H, F, MeO) were synthesized and evaluated for their in vitro antibacterial and antifungal activities. The min. inhibitory concentration tested against the same set of bacterial and fungal strains showed that I (R¹ = F, R² = H) against 閻?Hemolytic streptococcus and Klebsiella pneumoniae and I (R¹ = R² = F) against Escherichia coli and Pseudomonas had excellent antibacterial activity. Compounds I (R¹ = F, R² = H, MeO) showed inhibition against Aspergillus flavus, I (R¹ = Me, R² = F) against Microsporum gypseum, I (R¹ = F, R² = MeO) against Mucor, and compounds I (R¹ = Me, R² = MeO; R¹ = R² = F) against Rhizopus. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Formula: C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Formula: C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

High-throughput screening of 756 chemical contaminants in aquaculture products using liquid chromatography/quadrupole time-of-flight mass spectrometry was written by Bai, Mingkai;Tang, Ruixue;Li, Guorong;She, Wenhai;Chen, Gangjun;Shen, Hongmei;Zhu, Suqin;Zhang, Hongwei;Wu, Haohao. And the article was included in Food Chemistry: X in 2022.SDS of cas: 1220-83-3 This article mentions the following:

A high-throughput screening method embracing 756 multiclass chem. contaminants in aquaculture products was developed using modified QuEChERS extraction coupled with liquid chromatog./quadrupole time-of-flight mass spectrometry. A mega-database with retention time/accurate mass data for 524 pesticides, 182 veterinary drugs, 32 persistent organic pollutants and 18 marine toxins was established for compound identification via retrospective library searching. In the four representative matrixes (muscle tissues of tilapia and grouper, and edible portions of oyster and scallop), all the database compounds showed acceptable recovery and repeatability with the screening detection limit and limit of quantification below 0.01 mg/kg for >90% of them. The matrix-matched calibration revealed acceptable quant. property of the method in terms of linear range, linearity, and matrix effect, and fish muscle samples showed stronger matrix effect than shellfish samples. Anal. of 64 real-life samples from aquaculture farms and retail markets evidenced applicability of the proposed method to high-throughput screening scenarios. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3SDS of cas: 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.SDS of cas: 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and Antimicrobial Activity of Azolyl Pyrimidines was written by Butta, Ragavendra;Donthamsetty V, Sowmya;Adivireddy, Padmaja;Venkatapuram, Padmavathi. And the article was included in Journal of Heterocyclic Chemistry in 2017.Quality Control of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

A new class of azolyl pyrimidines I (X = O, S, NH; R = C₆H₅, 4-H₃CC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 4-O₂NC₆H₄) linked by diamino sulfone moiety was prepared and their antimicrobial activity was studied. Chloro-substituted and nitro-substituted thiazolyl pyrimidines I (X = S; R = 4-ClC₆H₄ and 4-O₂NC₆H₄) showed excellent antibacterial activity against Bacillus subtilis, while imidazolyl pyrimidines I (X = NH; R = 4-ClC₆H₄ and 4-O₂NC₆H₄) exhibited promising antifungal activity against Aspergillus niger. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Quality Control of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Quality Control of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents was written by Rawal, Ravindra K.;Tripathi, Rajkamal;Katti, S. B.;Pannecouque, Christophe;De Clercq, Erik. And the article was included in Bioorganic & Medicinal Chemistry in 2007.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

A series of 2-(2,6-dihalophenyl)-3-(substituted pyrimidinyl)-1,3-thiazolidin-4-ones were designed on the prediction of quant. structure-activity relationship (QSAR) studies, synthesized, and evaluated as HIV-1 reverse transcriptase inhibitors. Our attempts in correlating the identified mol. surface features related properties for modeling the HIV-1 RT inhibitory activity resulted in some statistically significant QSAR models with good predictive ability. The results showed that compounds 4m (I, R₁ = Cl) and 4n (I, R₁ = F) were highly active in inhibiting HIV-1 replication with EC₅₀ values in the range of 22-28 nM in MT-4 as well as in CEM cells with selectivity indexes of >10,000. The derived models collectively suggest that the compounds should be compact without bulky substitution on its peripheries for better HIV-1 RT inhibitory activity. These models also indicate a preference for hydrophobic compounds to obtain good HIV-1 RT inhibitory activity. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis of pyrimidine derivatives by the reaction of pyrylium salts with guanidine and compounds of its series was written by Zvezdina, E. A.;Zhdanova, M. P.;Dorofeenko, G. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1980.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

Treatment of pyrylium salts I (R = Ph, p-MeOC₆H₄, p-O₂NC₆H₄; R¹ = Ph) with H₂NC(:NH)NH₂.HBr gave 35-63% pyrimidinylpyridinium salts II. Pyrimidinum salts III (R = Ph, p-MeOC₆H₄) were obtained in 43 and 69% yield, resp. by reaction of I with methylguanidine nitrate. I and sulfanylguanidine gave pyridinium salts IV (R = R¹ = Ph, Me). 1,2,4,6-Tetraphenylpyridinium perchlorate was obtained in 25% yield by reaction of I with PhNHC(:NPh)NH₂. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Macroscopic Zn-doped 濞?Fe₂O₃/graphene aerogel mediated persulfate activation for heterogeneous catalytic degradation of sulfamonomethoxine wastewater was written by Dong, Shuying;Yan, Xuanxuan;Li, Wenli;Liu, Yafei;Han, Xiaoxu;Liu, Xiaodan;Feng, Jinglan;Yu, Chongfei;Zhang, Chunyan;Sun, Jianhui. And the article was included in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2022.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

In order to obtain a robust, durable and efficient heterogeneous catalyst, macroscopic monolithic Zn-doped 濞?Fe₂O₃/graphene aerogel (GA) hybrid architecture with integrated morphol. and hierarchically porous structure were controllably synthesized via a facile in-situ hydrothermal method and then used as persulfate (PS) activator for sulfamonomethoxine (SMM) wastewater purification Several key reaction parameters including the initial SMM concentration, reaction temperature, coexisting inorganic anions and SMM in real natural water samples had different influence on the SMM removal efficiency. The catalytic efficiency of Zn-doped 濞?Fe₂O₃/GA with the molar ratio of Fe/Zn = 2:1.5 was about 66%, 62%, 66% and 11%闂?3% higher than that of GA, 濞?Fe₂O₃/GA, Zn/GA and other Fe/Zn molar ratio. The improved activity of Fe/Zn = 2:1.5 benefits from the synergistic effects of the sp² hybridized carbon and porous framework, as well as the surface oxygenic functional groups, which accelerate the pollutant/oxidant dispersion and electron transfer. ESR results indicate that 閻犺櫣鏋綡, ¹O₂ and SO閻?sup>-₄ radicals account for the catalytic degradation of SMM and the activation of PS in present system is different from conventional homogeneous systems, and speculate mechanism was proposed based on the obtained data. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sedimentary spectrum and potential ecological risks of residual pharmaceuticals in relation to sediment-water partitioning and land uses in a watershed was written by Hong, Bing;Yu, Shen;Zhou, Min;Li, Juan;Li, Qi;Ding, Jing;Lin, Qiaoying;Lin, Xiaodan;Liu, Xun;Chen, Peiji;Zhang, Linlin. And the article was included in Science of the Total Environment in 2022.Name: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

Pharmaceutical residues in river surficial sediment are prone to anthropogenic impacts and environmental factors in watershed, but the mechanisms remain unclear. This study attempted to reveal surficial sediment-water pseudo-partitioning and anthropogenic (land use) patterns of pharmaceutical residues in surficial sediment among 23 subwatersheds of Jiulong River, southeast China with a gradient of urban land use percentile in dry and wet seasons. Thirty-eight out of target 86 compounds from six-category pharmaceuticals were quantified and ranged from below the quantification limits (0.001 mg kg^-1 dry mass) up to 8.19 mg kg^-1 dry mass (chlortetracycline) using a developed SPE-HPLC-MS/MS protocol. Antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) collectively dominated sedimentary pharmaceutical residues for 34.5-99.8% of the total quantified compounds (median at 92%). Land uses in subwatersheds showed high consistency with sedimentary pharmaceutical residues in the dry season rather than the wet season, especially for human use only and veterinary use only compounds Surficial sediment-water partitioning of pharmaceutical compounds influenced their sedimentary residues regardless of season, which were determined by properties of compound and surficial sediment interactively. All tetracycline compounds, trimethoprim (sulfonamides synergist), caffeine (central nervous system drug), and oxfendazole (antiparasitic drug) were quantified to pose high potential ecol. risks to aquatics. Findings of this study suggest that pseudo-persistent legacy of human and veterinary pharmaceuticals requires a wider coverage of pharmaceutical compounds for a comprehensive ecol. assessment in the environment and more involvement of anthropogenic impacts and socioeconomic factors in the future studies. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Name: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Name: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hyperactive magnetically separable nano-sized MgFe₂O₄ catalyst for the synthesis of several five- and six-membered heterocycles was written by Bansal, Shobha;Kumar, Yogendra;Das, Dipak Kumar;Singh, Prabal Pratap. And the article was included in Chemistry & Chemical Technology in 2019.Recommanded Product: 40230-24-8 This article mentions the following:

MgFe₂O₄ nanoparticle ferrites were synthesized by combustion technique using pure ferric nitrate and magnesium nitratecarbonate. The magnetically separable MgFe₂O₄ MNP’s were found to be hyper active catalyst for the synthesis of a wide range of biol. active five and six-membered heterocyclic moieties at refluxing conditions. Reaction times were lowest in comparison to all reported in literature with excellent yields. Strong electron pull of Fe³⁺ was responsible for its hyper activity, which was substantiated by substitution of Fe³⁺ by other trivalent metal ions. Mg²⁺ contain a unique role because replacement of Mg²⁺ has poor catalytic activity. The developed protocol was efficiently utilized for the synthesis of a series of substituted mono/bis pyrimidines, pyrimidin-2-ol, pyrimidin-2-thiol, pyrazoles and isoxazoles by condensing monochalcones/1,4-bischalcones with various bis-nucleophiles in the presence of catalytic amount of heterogenous magnetic MgFe₂O₄ nanoparticles. The structure of these synthesized compounds was determined by FTIR, ¹H, ¹³C and mass spectra. The catalyst was removed easily from reaction mixture by using a simple external magnet. Nanoparticles of ferrite were recovered and reused with no appreciable change in the activity even after the five runs. Nanoparticles were characterized by XRD, TEM and IR spectroscopy. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Recommanded Product: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of silanized melamine sponges in matrix purification for rapid multi-residue analysis of veterinary drugs in eggs by UPLC-MS/MS was written by Xu, Xu;Zhao, Wenhao;Ji, Baocheng;Han, Yu;Xu, Gaigai;Jie, Mingsha;Wu, Nan;Wu, Yongmei;Li, Junguang;Li, Ke;Zhao, Dianbo;Bai, Yanhong. And the article was included in Food Chemistry in 2022.Application of 1220-83-3 This article mentions the following:

Fast and convenient matrix purification is an important prerequisite for high-throughput anal. of drug multiresidues in food. In this study, a silanized melamine sponge was prepared and first applied in the rapid determination of multiclass veterinary drugs in eggs by ultrahigh-performance liquid chromatog.-tandem mass spectrometry. Within five seconds, fast, convenient and efficient matrix separation could be achieved through simple soaking and squeezing. Compared to other matrix adsorbents, the developed material demonstrated equivalent or better purification performance. Good validation results were obtained in terms of drug recoveries (61.5%闂?7.0%, relative standard deviation (RSD) 闂?10.8%), and linearities (R2 闂?0.999), as well as low limits of quantitation (0.3 闂?10.9婵炴挾鎸撮悹铏规）g-1) and detection (0.1 闂?3.8婵炴挾鎸撮悹铏规）g-1). By analyzing 52 egg samples, high concentrations of ofloxacin, trimethoprim, metronidazole, and dimetridazole were found at 542.9, 121.2, 66.1 and 58.0婵炴挾鎸撮悹铏规）g-1, resp. The silanized melamine sponge has shown its great potential for rapid anal. of multiclass residues in food safety. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Application of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ionic Liquid-Coated Nanoparticles (CaO@SiO₂@BAIL): A Bi-Functional and Environmentally Benign Catalyst for Green Synthesis of Pyridine, Pyrimidine, and Pyrazoline Derivatives was written by Sameri, Fatemeh;Bodaghifard, Mohammad Ali;Mobinikhaledi, Akbar. And the article was included in Polycyclic Aromatic Compounds in 2022.Name: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

A novel ionic liquid-coated nanomaterials (CaO@SiO₂@BAIL) was successfully synthesized by anchoring the 1-(3-(trimethoxysilyl)propyl)-1,3,5,7-tetraazaadamantan-1-ium chlorozincate (II) bi-functional ionic liquid (BAIL) onto the surface of silica-coated CaO nanoparticles. The structure of catalyst was characterized using various anal. techniques such as Fourier-transform IR spectroscopy (FT-IR), X-ray powder diffraction (XRD), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), WDS map scan, thermogravimetric (TGA), and inductively-coupled plasma-mass spectrometry (ICP-MS). The performances of prepared hybrid nanomaterial (CaO@SiO₂@BAIL) as a catalyst were evaluated for the efficient synthesis of the pharmaceutically valuable heterocyclic compounds A variety of pyridine, pyrimidine, and pyrazoline derivatives were synthesized in the presence of CaO@SiO₂@BAIL within green conditions. The presented method has several advantages such as high yields, low reaction times, and easy preparation of the catalyst. The bi-functional heterogeneous nanocatalyst can be reused at least six times without considerable loss of its catalytic activity. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Name: 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Name: 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia