Tag: 200-300

COA of Formula: C11H8N2O4On October 1, 2015 ,《N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Chapman, Timothy M.; Wallace, Claire; Gillen, Kevin J.; Bakrania, Preeti; Khurana, Puneet; Coombs, Peter J.; Fox, Simon; Bureau, Emilie A.; Brownlees, Janet; Melton, David W.; Saxty, Barbara. The article contains the following contents:

A high throughput screen allowed the identification of N-hydroxyimide inhibitors of ERCC1-XPF endonuclease activity with micromolar potency, but they showed undesirable selectivity profiles against FEN-1. A scaffold hop to a hydroxypyrimidinone template gave compounds with similar potency but allowed selectivity to be switched in favor of ERCC1-XPF over FEN-1. Further exploration of the structure-activity relationships around this chemotype gave sub-micromolar inhibitors with >10-fold selectivity for ERCC1-XPF over FEN-1. In the experiment, the researchers used many compounds, for example, 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2COA of Formula: C11H8N2O4)

5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. COA of Formula: C11H8N2O4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《On the Way Towards Greener Transition-Metal-Catalyzed Processes as Quantified by E Factors》 was published in Angewandte Chemie, International Edition in 2013. These research results belong to Lipshutz, Bruce H.; Isley, Nicholas A.; Fennewald, James C.; Slack, Eric D.. Reference of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine The article mentions the following:

Transition-metal-catalyzed carbon-carbon and carbon-heteroatom bond formations are among the most heavily used types of reactions in both academic and industrial settings. As important as these are to the synthetic community, such cross-couplings come with a heavy price to our environment, and sustainability. E Factors are one measure of waste created, and organic solvents, by far, are the main contributors to the high values associated, in particular, with the pharmaceutical and fine-chem. companies which utilize these reactions. An alternative to organic solvents in which cross-couplings are run can be found in the form of micellar catalysis, wherein nanoparticles composed of newly introduced designer surfactants enable the same cross-couplings, albeit in water, with most taking place at room temperature In the absence of an organic solvent as the reaction medium, organic waste and hence, E Factors, drop dramatically. After reading the article, we found that the author used 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6Reference of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine)

4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Reference of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Lefebvre, Carole-Anne; Forcellini, Elsa; Boutin, Sophie; Cote, Marie-France; C.-Gaudreault, Rene; Mathieu, Patrick; Lague, Patrick; Paquin, Jean-Francois published an article on January 15 ,2017. The article was titled 《Synthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Name: 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine The information in the text is summarized as follows:

The synthesis of two series of novel substituted pyrimidine derivatives bearing a sulfamide group have been described and their in vitro cancer growth inhibition activities have been evaluated against three human tumor cell lines (HT-29, M21, and MCF7). In general, growth inhibition activity has been enhanced by the introduction of a bulky substituent on the aromatic ring with the best compound having GI50 < 6 μM for all the human tumor cell lines. The MCF7 selective compounds were evaluated on four addnl. human invasive breast ductal carcinoma cell lines (MDA-MB-231, MDA-MB-468, SKBR3, and T47D) and were selective against T47D cell line in all cases except one, suggesting a potential antiestrogen activity. In addition to this study using 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine, there are many other studies that have used 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6Name: 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine) was used in this study.

4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Name: 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidineThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidineOn March 15, 2008, Doherty, Elizabeth M.; Retz, Daniel; Gavva, Narender R.; Tamir, Rami; Treanor, James J. S.; Norman, Mark H. published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《4-Aminopyrimidine tetrahydronaphthols: A series of novel vanilloid receptor-1 antagonists with improved solubility properties》. The article mentions the following:

8-{6-[4-(Trifluoromethyl)phenyl]pyrimidin-4-ylamino}-1,2,3,4-tetrahydronaphthalen-2-ol and its analogs were shown to be potent inhibitors of human and rat TRPV1 in vitro with increased solubility Synthesis, SAR, and improvements in metabolic stability and absorption of these compounds are described. The experimental process involved the reaction of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6Quality Control of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine)

4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Quality Control of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidineThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia