Tag: 300-400

On December 16, 2015, Liang, Ruiyong; Gao, Hai published a patent.SDS of cas: 23256-42-0 The title of the patent was Environmentally friendly waterborne coating compositions. And the patent contained the following:

The compositions, having low VOC content, contain waterborne acrylic emulsions 91-100, polydicyclopentadiene 1-2, ammonium molybdate 0.5-1, iron trifluoroacetylacetonate 0.1-0.2, polypropylene glycol 1-2, potassium silicate 1-2, octyl epoxystearate 2-4, 2-mercaptobenzimidazole 0.5-1, ultrafine barium sulfate 10-12, polymethyl acrylate 2-3, dodecyl di-Me amine oxide 0.3-1, flame retardant aids 2-4, ethylene glycol Bu ether 2-3, and deionized water 20-30 parts. The flame retardant aids contain microcapsulated red phosphorus, polycarbonates, aluminum magnesium silicate, lithium-based bentonite, trimethoprim lactate, trimethylolpropane, and isooctyl acrylate. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).SDS of cas: 23256-42-0

The Article related to flame retardant acrylic emulsion waterborne coating composition, Coatings, Inks, and Related Products: Acrylic and Water-Sol (Electrophoretic) Resin Coatings and other aspects.SDS of cas: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 27, 2011, Yoshida, Masaru; Azuma, Takeshi; Yamamoto, Koji; Nishitani, Yosuke published a patent.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Method and nutritive media for in vitro culture of Helicobacter heilmannii, culture products, and method for separation and detection of the Helicobacter. And the patent contained the following:

The nutritive media contain base media and catalase. The culture products contain Helicobacter heilmannii and no other microorganisms. Thus, oral administration of homogenized pig gastric mucosa to mouses, homogenization of the mouse gastric mucosa, culture of the homogenized products in a sheep blood-added trypticase soy agar culture medium containing catalase, and culture of the resulting colony two times gave a culture product, which was subjected to urease gene anal. to show high base sequence homol. with urease base sequence from in vivo-cultured Helicobacter heilmannii. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to nutritive media culture helicobacter separation detection catalase, helicobacter culture sheep blood trypticase soy agar, pig gastric mucosa helicobacter urease sequence detection and other aspects.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Brumfitt, W.; Hamilton-Miller, J. M. T.; Grey, Daphne published an article in 1977, the title of the article was Antibacterial activity of combinations of clindamycin and antifolate agents.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate And the article contains the following content:

The antibacterial activities of clindamycin-HCl (I-HCl) [21462-39-5] in combination with the folate antagonists trimethoprim lactate [23256-42-0] or sulfamethoxazole [723-46-6] were only additive, suggesting that I is not an antifolate agent. Thus, some other mechanism of action must be responsible for the therapeutic effects of I against malaria and toxoplasmosis, conditions known to be susceptible to treatment with antifolate compounds Inhibition of protein synthesis is the most likely explanation for the action of I, but other antibiotics which inhibit bacterial protein synthesis have generally shown little activity against malaria. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to clindamycin bactericidal action, trimethoprim clindamycin bactericidal activity, sulfamethoxazole clindamycin bactericidal activity, folate antagonist clindamycin bacteria and other aspects.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 27, 2011, Yoshida, Masaru; Azuma, Takeshi; Yamamoto, Koji; Nishitani, Yosuke published a patent.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Method and nutritive media for in vitro culture of Helicobacter heilmannii, culture products, and method for separation and detection of the Helicobacter. And the patent contained the following:

The nutritive media contain base media and catalase. The culture products contain Helicobacter heilmannii and no other microorganisms. Thus, oral administration of homogenized pig gastric mucosa to mouses, homogenization of the mouse gastric mucosa, culture of the homogenized products in a sheep blood-added trypticase soy agar culture medium containing catalase, and culture of the resulting colony two times gave a culture product, which was subjected to urease gene anal. to show high base sequence homol. with urease base sequence from in vivo-cultured Helicobacter heilmannii. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to nutritive media culture helicobacter separation detection catalase, helicobacter culture sheep blood trypticase soy agar, pig gastric mucosa helicobacter urease sequence detection and other aspects.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Brumfitt, W.; Hamilton-Miller, J. M. T.; Grey, Daphne published an article in 1977, the title of the article was Antibacterial activity of combinations of clindamycin and antifolate agents.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate And the article contains the following content:

The antibacterial activities of clindamycin-HCl (I-HCl) [21462-39-5] in combination with the folate antagonists trimethoprim lactate [23256-42-0] or sulfamethoxazole [723-46-6] were only additive, suggesting that I is not an antifolate agent. Thus, some other mechanism of action must be responsible for the therapeutic effects of I against malaria and toxoplasmosis, conditions known to be susceptible to treatment with antifolate compounds Inhibition of protein synthesis is the most likely explanation for the action of I, but other antibiotics which inhibit bacterial protein synthesis have generally shown little activity against malaria. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to clindamycin bactericidal action, trimethoprim clindamycin bactericidal activity, sulfamethoxazole clindamycin bactericidal activity, folate antagonist clindamycin bacteria and other aspects.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 31, 2012, Zeng, Yan-Bo; Zhu, Shun-Hai; Dong, Hui; Han, Hong-Yu; Jiang, Lian-Lian; Wang, Quan; Cheng, Jun; Zhao, Qi-Ping; Ma, Wei-Jiao; Huang, Bing published an article.COA of Formula: C17H24N4O6 The title of the article was Great efficacy of sulfachloropyrazine-sodium against acute murine toxoplasmosis. And the article contained the following:

Objective: To identify more effective and less toxic drugs to treat animal toxoplasmosis. Methods: Efficacy of seven kinds of sulfonamides against Toxoplasma gondii (T. gondii) in an acute murine model was evaluated. The mice used throughout the study were randomly assigned to many groups (10 mice each), which either remained uninfected or were infected i.p. with tachyzoites of T. gondii (strains RH and CN). All groups were then treated with different sulfonamides and the optimal treatment protocol was determined candidates. Sulfadiazine-sodium (SD) was used for comparison. Results: The optimal therapy involved gavaging mice twice per day with 250 mg/kg bw of sulfachloropyrazine-sodium (SPZ) for five days. Using this protocol, the average survival time and the time-point of 50% fatalities were prolonged significantly compared with SD treatment. Treatment with SPZ protected 40% of mice from death, and the heart and kidney tissue of these animals was parasite-free, as determined by nested-PCR, SPZ showed excellent therapeutic effects in the treatment of T. gondii in an acute murine model and is therefore a promising drug candidate for the treatment and prevention of T. gondii in animals. Conclusions: II can be concluded that the effective drug sulfachloropyrazine may be the new therapeutic options against animal toxoplasmosis. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).COA of Formula: C17H24N4O6

The Article related to protozoacide sulfachloropyrazine sodium toxoplasma toxoplasmosis heart liver lung kidney, efficacy, murine, sulfachloropyrazine-sodium, sulfonamides, therapeutic effect, therapy, toxoplasma gondii, toxoplasmosis and other aspects.COA of Formula: C17H24N4O6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《A pharmacological network for lifespan extension in Caenorhabditis elegans》 was written by Ye, Xiaolan; Linton, James M.; Schork, Nicholas J.; Buck, Linda B.; Petrascheck, Michael. Recommanded Product: 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine And the article was included in Aging Cell on April 30 ,2014. The article conveys some information:

Summary: One goal of aging research is to find drugs that delay the onset of age-associated disease. Studies in invertebrates, particularly Caenorhabditis elegans, have uncovered numerous genes involved in aging, many conserved in mammals. However, which of these encode proteins suitable for drug targeting is unknown. To investigate this question, we screened a library of compounds with known mammalian pharmacol. for compounds that increase C. elegans lifespan. We identified 60 compounds that increase longevity in C. elegans, 33 of which also increased resistance to oxidative stress. Many of these compounds are drugs approved for human use. Enhanced resistance to oxidative stress was associated primarily with compounds that target receptors for biogenic amines, such as dopamine or serotonin. A pharmacol. network constructed with these data reveal that lifespan extension and increased stress resistance cluster together in a few pharmacol. classes, most involved in intercellular signaling. These studies identify compounds that can now be explored for beneficial effects on aging in mammals, as well as tools that can be used to further investigate the mechanisms underlying aging in C. elegans. In the experiment, the researchers used 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8Recommanded Product: 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine)

7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Recommanded Product: 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2018,Molecules included an article by Naboulsi, Imane; Aboulmouhajir, Aziz; Kouisni, Lamfeddal; Bekkaoui, Faouzi; Yasri, Abdelaziz. Application of 213743-31-8. The article was titled 《Combining a QSAR approach and structural analysis to derive an SAR map of Lyn kinase inhibition》. The information in the text is summarized as follows:

Lyn kinase, a member of the Src family of protein tyrosine kinases, is mainly expressed by various hematopoietic cells, neural and adipose tissues. Abnormal Lyn kinase regulation causes various diseases such as cancers. Thus, Lyn represents, a potential target to develop new antitumor drugs. In the present study, using 176 mols. (123 training set mols. and 53 test set mols.) known by their inhibitory activities (IC50) against Lyn kinase, we constructed predictive models by linking their physico-chem. parameters (descriptors) to their biol. activity. The models were derived using two different methods: the generalized linear model (GLM) and the artificial neural network (ANN). The ANN Model provided the best prediction precisions with a Square Correlation coefficient R2 = 0.92 and a Root of the Mean Square Error RMSE = 0.29. It was able to extrapolate to the test set successfully (R2 = 0.91 and RMSE = 0.33). In a second step, we have analyzed the used descriptors within the models as well as the structural features of the mols. in the training set. This anal. resulted in a transparent and informative SAR map that can be very useful for medicinal chemists to design new Lyn kinase inhibitors. The experimental part of the paper was very detailed, including the reaction process of 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8Application of 213743-31-8)

7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 213743-31-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Crich, David; Yao, Qingwei published an article on January 15 ,1998. The article was titled 《Free radical chemistry of nucleosides and nucleotides Ring opening of C4′-radicals》, and you may find the article in Tetrahedron.Related Products of 122567-97-9 The information in the text is summarized as follows:

It is demonstrated that nucleotide C4′ radicals may be generated from a C4′-thioester on treatment with tributyltin hydride. When the reaction is conducted in benzene at reflux the C4′ radical expels the C3′-phosphate group to give a radical cation. This species undergoes deprotonation to an allylic radical which suffers cleavage of the deoxyribose ring. Similar reactions are observed when the reaction is conducted with tris(trimethylsilyl)silane in place of the stannane. In methanolic benzene the radical cation is trapped by methanol to give a new C4′ radical which is quenched before ring opening. The behavior of C4′ radicals toward ring opening is discussed in terms of the conformations imposed by the substituents at C3′. In the experimental materials used by the author, we found ((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9Related Products of 122567-97-9)

((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 122567-97-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Li, Si; Wu, Bin; Zheng, Xu; Wang, Changyuan; Zhao, Jingyuan; Sun, Huijun; Sun, Xiuli; Tang, Zeyao; Yuan, Hong; Chen, Lixue; Ma, Xiaodong published an article on January 31 ,2021. The article was titled 《Synthesis and biological activity of imidazole group-substituted arylaminopyrimidines (IAAPs) as potent BTK inhibitors against B-cell lymphoma and AML》, and you may find the article in Bioorganic Chemistry.Synthetic Route of C12H6ClN3O3S The information in the text is summarized as follows:

Bruton’s tyrosine kinase (BTK) is a member of the Tec kinase family and plays a key role in the modulation of the B-cell receptor (BCR)-mediated signaling pathway. Inhibition of BTK has been proven to be an effective therapeutic approach for various hematol. malignancies, such as chronic lymphocytic leukemia (CLL), mantle cell leukemia (MCL), diffuse large B-cell lymphoma (DLBCL) and acute myeloid leukemia (AML). Here, a new series of imidazole group-substituted arylaminopyrimidines (IAAPs) were designed and synthesized as potent inhibitors of the enzymic activity of BTK with a half maximal inhibitory concentration (IC50) ranging from 13.10 to 42.40 nM. In particular, 11a and 11b exhibited stronger antiproliferative activity against AML and B lymphomas cell lines compared with BTK inhibitor ibrutinib and showed low cytotoxicity against normal peripheral blood mononuclear cells (PBMCs). In addition, anal. of the mechanism of action of these compounds revealed that 11a and 11b induced significant apoptosis in AML and B lymphoma cells by arresting the cell cycle at the G1/G0 or G2/M stage and blocked BTK autophosphorylation as well as the ensuing abrogation of pro-survival AKT and ERK signaling. Taken together, these results suggest that 11a and 11b might serve as valuable preclin. candidates for the treatment of AML and B-cell lymphoma. After reading the article, we found that the author used 2-Chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine(cas: 1353553-07-7Synthetic Route of C12H6ClN3O3S)

2-Chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine(cas: 1353553-07-7) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Synthetic Route of C12H6ClN3O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia