Tag: 300-400

Mustafin, A. G.; Suyundukova, M. V.; Gataullin, R. R.; Spirikhin, L. V.; Abdrakhmanov, I. B.; Tolstikov, G. A. published an article in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). The title of the article was 《Transformations of β-D-xylofuranosyl nucleosides. The effective synthesis of 2′,3′-dideoxy-2′,3′-didehydrothymidine》.SDS of cas: 122567-97-9 The author mentioned the following in the article:

We have shown earlier that heating 1-(2′-O-tosyl-3′,5′-di-O-benzoyl-β-D-xylofuranosyl)thymine with NaI leads to a mixture of 2,2′-anhydronucleoside and 5′-O-benzoyl-2′,3′-dideoxy-2′,3′-didehydrothymidine. We now continue our search for efficient methods of introducing a double bond at position 2′,3′ of the sugar moiety and found that the reaction of a 2,2′-anhydro compound with HI in anhydrous 1,2-dimethoxyethane leads to a 2′,3′-didehydronucleoside. The experimental part of the paper was very detailed, including the reaction process of ((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9SDS of cas: 122567-97-9)

((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.SDS of cas: 122567-97-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《High-throughput identification of small molecules that affect human embryonic vascular development》 was written by Vazao, Helena; Rosa, Susana; Barata, Tania; Costa, Ricardo; Pitrez, Patricia R.; Honorio, Ines; de Vries, Margreet R.; Papatsenko, Dimitri; Benedito, Rui; Saris, Daniel; Khademhosseini, Ali; Quax, Paul H. A.; Pereira, Carlos F.; Mercader, Nadia; Fernandes, Hugo; Ferreira, Lino. Product Details of 213743-31-8 And the article was included in Proceedings of the National Academy of Sciences of the United States of America on April 11 ,2017. The article conveys some information:

Birth defects, which are in part caused by exposure to environmental chems. and pharmaceutical drugs, affect 1 in every 33 babies born in the United States each year. The current standard to screen drugs that affect embryonic development is based on prenatal animal testing; however, this approach yields low-throughput and limited mechanistic information regarding the biol. pathways and potential adverse consequences in humans. To develop a screening platform for mols. that affect human embryonic development based on endothelial cells (ECs) derived from human pluripotent stem cells, we differentiated human pluripotent stem cells into embryonic ECs and induced their maturation under arterial flow conditions. These cells were then used to screen compounds that specifically affect embryonic vasculature. Using this platform, we have identified two compounds that have higher inhibitory effect in embryonic than postnatal ECs. One of them was fluphenazine (an antipsychotic), which inhibits calmodulin kinase II. The other compound was pyrrolopyrimidine (an antiinflammatory agent), which inhibits vascular endothelial growth factor receptor 2 (VEGFR2), decreases EC viability, induces an inflammatory response, and disrupts preformed vascular networks. The vascular effect of the pyrrolopyrimidine was further validated in prenatal vs. adult mouse ECs and in embryonic and adult zebrafish. We developed a platform based on human pluripotent stem cell-derived ECs for drug screening, which may open new avenues of research for the study and modulation of embryonic vasculature. In the experiment, the researchers used many compounds, for example, 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8Product Details of 213743-31-8)

7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Product Details of 213743-31-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of C23H22N4OOn June 1, 2001, Banic Tomisic, Zrinka; Cempuh, Andreja; Malnar, Ivica published an article in Acta Crystallographica, Section E: Structure Reports Online. The article was 《7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-4-ylamine, a lck tyrosine kinase inhibitor》. The article mentions the following:

The mol. and crystal structures of the potent and selective lck tyrosine kinase inhibitor, C23H22N4O, were determined by single-crystal x-ray diffraction. The pyrrolopyrimidine and Ph rings are planar while the cyclopentyl ring adopts a conformation between envelope and half-chair. The overall conformation is defined by the spatial arrangement of the ring moieties. Crystallog. data are given. In the part of experimental materials, we found many familiar compounds, such as 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8Electric Literature of C23H22N4O)

7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Electric Literature of C23H22N4O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia