Tag: M.W:100-200

56-09-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Palladium catalysts 31a-c, 103, 104 and 105 were synthesized following reported procedures.20,24 2-amino-4,6-dihydroxypyrimidine or pyrimidine-4,6-diol based ligands (95 and 97) (20.0 mumol) weredissolved in an aqueous solution of YOH (0.4 mL, 0.1m) in an ultrasonic bath for 2 minutes. Thepalladium source (10.0 mumol) was added and the mixture was magnetically stirred at 65 C for 30 minutes, deionized water (0.6 mL) was then added to afford a 10.0 mM catalyst solutions of 31a-c and,103-105. The 40.0 mM catalyst solution was achieved with a 0.2 M solution of YOH.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 56-09-7, 2-Amino-6-hydroxypyrimidin-4(3H)-one.

Reference:
Article; Tessier, Romain; Ceballos, Javier; Guidotti, Nora; Simonet-Davin, Raphael; Fierz, Beat; Waser, Jerome; Chem; vol. 5; 8; (2019); p. 2243 – 2263;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A common compound: 3934-20-1, name is 2,4-Dichloropyrimidine,molecular formula is C4H2Cl2N2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 3934-20-1

To a solution of 2, 4-dichloro-pyrimidine (15-0 g) in THF (150 mL) was added 50% aqueous Me2NH (22.7 g). The mixture was stirred at ambient temperature for 2 hr and poured into saturated aqueous NaHC03. The aqueous layer was extracted with CHC13 (three times). The combined organic layer was dried over MgS04, filtrated, concentrated under reduced pressure, and purified by flash chromatography (NH-silica, 20% EtOAc in hexane) to give (2-chloro-pyrimidin-4-yl)-dimethyl-amine (8.66 g) and (4-chloro- pyrimidin-2-yl)-dimethyl-amine (0.87 g). (2-chloro-pyrimidin-4-yl)-dimethyl-amine; CI MS m/e 158, M + For : 1H NMR (300 MHz, CDC13) 8 3.12 (s, 6 H), 6. 32 (d, J= 6.1 Hz, 1 H), 8.00 (d, J = 6.1 Hz, 1 H). (4-chloro-pyrimidin-2-yl)-dimethyl-amine ; ESI MS m/e 157, M> ;’H NMR (300 MHz, CDCI3) No. 3. 21 (s, 6 H), 6.50 (d, J= 5.1 Hz, 1 H), 8.18 (d, J= 5. 1 Hz, 1 H).

With the rapid development of chemical substances, we look forward to future research findings about 3934-20-1.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; Arena Pharmaceuticals, Inc; WO2005/95357; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

504-17-6, Adding a certain compound to certain chemical reactions, such as: 504-17-6, 4,6-Dihydroxy-2-mercaptopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 504-17-6, blongs to pyrimidines compound.

General procedure: [H2-DABCO][H2PO4]2 (0.065mmol, 0.020 g) was added to a mixture of the aromatic aldehyde (1 mmol), malononitrile (1 mmol) and barbituric or thiobarbituric acid (1 mmol) in water (3 mL). Then the mixture was heated at 75 C while was monitored by TLC (n-hexane:ethyl acetate; 1:9). After completion of the reaction, the mixture was cooled to room temperature and the solid productwas filtered, washed with cold distilled water (2 mL) and was recrystallized from warm ethanol if necessary.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,504-17-6, its application will become more common.

Reference:
Article; Shirini, Farhad; Langarudi, Mohaddeseh Safarpoor Nikoo; Daneshvar, Nader; Journal of Molecular Liquids; vol. 234; (2017); p. 268 – 278;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5750-76-5, name is 2,4,5-Trichloropyrimidine. A new synthetic method of this compound is introduced below., 5750-76-5

General procedure: 2-Amino-N-methylbenzamide 10 was prepared according tothe general procedure in literatures 33-35. The prepared 2-amino-N-methylbenzamide 10 (1.00 g, 6.67 mmol) was added inone portion to 2,4,5-trichloropyrimidine (1.22 g, 6.67 mmol) or2,4-dichloro-5-nitropyrimidine (1.29 g, 6.67 mmol) and DIPEA(1.29 g, 10.0 mmol) in isopropanol (100 mL). The resulting mixturewas stirred at 85 C for 6 h. The mixture was evaporated to dryness,and the residue was recrystallised from MeCN/water 20:1to yield 2-(2-chloro-5-substitudedpyrimidin-4-ylamino)-Nmethylbenzamide(1.69 g, 85%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5750-76-5, 2,4,5-Trichloropyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Liu, He; Wu, Bin; Ge, Yang; Huang, Jiaxin; Song, Shijie; Wang, Changyuan; Yao, Jihong; Liu, Kexin; Li, Yanxia; Li, Yongming; Ma, Xiaodong; Bioorganic and Medicinal Chemistry; vol. 25; 24; (2017); p. 6313 – 6321;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

213265-83-9, A common compound: 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine,molecular formula is C4HCl2FN2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Intermediate A39-2 (200mg, 1.07mmol) was dissolved in tetrahydrofuran (5mL), was added 4,6-dichloro-5-fluoropyrimidine (179mg, 1.07mmol),Diisopropylethyl amine (414mg, 3.21mmol), 50 stirred overnight, cooled to room temperature, spin dry solvent, the residue was purified by column chromatography (dichloromethane:Methanol = 150: 1) to give a colorless oil (240mg, 71%). 1HNMR (400MHz, CDCl3) delta8.23 (s, 1H), 7.51 (s, 1H),7.45-7.40 (m, 4H), 6.30 (s, 1H), 5.55 (s, 1H), 4.79 (d, J = 6.0Hz, 2H), 3.89 (s, 3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 213265-83-9.

Reference:
Patent; Suzhou Yunxuan Pharmaceutical Co., Ltd.; Zhang, Xiaohu; (54 pag.)CN105254613; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

156-81-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 156-81-0 as follows.

2-(3-Fluoro-phenyl)-imidazo[1,2-a]pyrimidin-7-ylamine 2-Bromo-1-(3-fluorophenyl)ethanone (10.9 g, 50 mmol) was added to a solution of 2,4-diaminopyrimidine (3.70 g, 34 mmol) in acetone (185 ml), and the mixture was heated to reflux for 6 h. The cooled suspension was filtered and the precipitate was washed with acetone (50 ml). The solid was re-suspended in water (35 ml) and NH4OHaq. (25%, 50 ml), then it was collected over a glass fiber paper and the filtrate was washed with H2O (75 ml). After drying under vacuum, the product was obtained (5.56 g, 72%) as a yellow solid. MS (m/z)=229.1 [M+H+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,156-81-0, its application will become more common.

Reference:
Patent; Alvarez Sanchez, Ruben; Bleicher, Konrad; Flohr, Alexander; Gobbi, Luca; Groebke Zbinden, Katrin; Koerner, Matthias; Kuhn, Bernd; Peters, Jens-Uwe; Rudolph, Markus; US2011/237564; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some common heterocyclic compound, 137234-74-3, molecular formula is C6H6ClFN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.137234-74-3

In a 500 mL three-necked flask, 150 mL of dichloroethane was added, 34.1 g of the chlorinated product prepared in the same manner as in the above step (3)1.5 g of azobisisobutyronitrile(AIBN) 28.4 g of N-bromosuccinimide(NBS) was dissolved in 50 mL of dichloroethane, Then drop into the reaction bottle, add dichloroethane 50mL. After the reaction solution was clarified, a mixed solution of 22.1 g of NBS dissolved in 100 mL of dichloroethane was added dropwise, and the mixture was heated to 50 C and reacted for 15 h. After the completion of the reaction, 100 mL of water was added to separate the aqueous phase and the organic phase. The aqueous phase was extracted with 80 mL of dichloroethane and the organic layers were combined. The organic layer was washed with sodium bisulfite solution and the organic layer was washed with water The organic layer was dried over anhydrous sodium sulfate,The solvent dichloroethane was distilled off under reduced pressure to obtain 52.6 g of the target compound 4-(1-bromoethyl)-5-fluoro-6-chloropyrimidine as a pale yellow liquid in a yield of 92%, and the purity of the high performance liquid chromatography was 86% .

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 137234-74-3.

Reference:
Patent; JUHUA Group Technology Center; YANG, JIANRONG; GE, CHENGSHENG; LI, JIAN; (8 pag.)CN103896855; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5750-76-5, name is 2,4,5-Trichloropyrimidine. A new synthetic method of this compound is introduced below., 5750-76-5

2-(isopropylsulfonyl)aniline (1g, 5.02mmol) and 2,4,5-trichloropyrimidine (1.1g, 6mmol) was dissolved in N,N-dimethylformamide (30 mL) and added sodium hydride (content 60%, 0.4g, 10mmol) then reacted at 25C for 12 hours. Water (20mL) was added then extracted with ethyl acetate (30mL ¡Á 3). The organic phases were combined, washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 25: 1) gave the product (0.8g, 46% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5750-76-5, 2,4,5-Trichloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Shandong Xuanzhu Pharma Co., Ltd.; Wu, Yongqian; (28 pag.)CN105524045; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

696-82-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 696-82-2, name is 2,4,6-Trifluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 2,4,6-trifluoropyrimidine (278 mg, 2.07 mmol) in Et20 (10 mL) is cooled to -20 C and is treated, dropwise, with a solution of tert-butyl 4-[[4-[(1S)-1- aminoethyllphenyllmethyllpiperazine-1-carboxylate (600 mg, 1.88 mmol) in Et20 (10 mL). The resulting mixture is stirred at -20 C for 1 hour and is then allowed to warm to room temperature and is stirred overnight. The solids are removed by filtration and arewashed with additional Et20. The filtrate is washed with water, using a small portion of NaC1 additive to reduce emulsification, and the aqueous layer is back-extracted with Et20 (lx) and CH2C12 (lx). The combined organic extracts are then dried (Na2SO4), filtered,and concentrated to give a crude product that is purified by silica gel chromatographyeluting with 20-60% EtOAc/hexanes to give the title compound as a pale yellow oil (606 mg, 1.40 mmol, 74%). ES/MS (mlz): 434 (M+H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 696-82-2, 2,4,6-Trifluoropyrimidine.

Reference:
Patent; ELI LILLY AND COMPANY; LUMERAS AMADOR, Wenceslao; BAUER, Renato A.; BOULET, Serge Louis; BURKHOLDER, Timothy Paul; GILMOUR, Raymond; HAHN, Patric James; CARBALLARES MARTIN, Santiago; RANKOVIC, Zoran; (80 pag.)WO2017/213910; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

4595-59-9 , The common heterocyclic compound, 4595-59-9, name is 5-Bromopyrimidine, molecular formula is C4H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: In a 5 mL flask, aryl halide (1 mmol), alkyl halide (1.1 mmol),thiourea (91 mg, 1.2 mmol), CuFe2O4(12 mg, 5 mol%), K2CO3(552 mg, 4.0 mmol), H2O (0.3 mL), and PEG (2 mL) were added and stirred at 80-100C for the appropriate reaction time. After completion of reaction, the mixture was cooled to room temperature and washed with 5 mL H2O and 10 mL EtOAc. Then,after separation and evaporation of organic solvent, the crude thioethers, were purified by flash column chromatography on silica gel eluted with the appropriate mixture of (EtOAc/n-hexane).

According to the analysis of related databases, 4595-59-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Gholinejad, Mohammad; Karimi, Babak; Mansouri, Fariborz; Journal of Molecular Catalysis A: Chemical; vol. 386; (2014); p. 20 – 27;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia