Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 1780-26-3, 2-Methyl-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1780-26-3, blongs to pyrimidines compound. 1780-26-3

To a cooled solution of 2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5- carboxamide( 100 gm) and 4,6-Dichloro-2-methylpyrimidine(66. 96 gm) in THF(5 00 ml), was added sodium tert-butoxide(125.62 gm). The reaction mixture was allowed to cooled at 0-10C. Concentrated HC1 (80 ml) was added. The reaction mixture was heated to 25¡À5C for 1-2h and was cooled to 0-10C. The precipitated solid was filtered, washed with water (200 ml) and dried to obtain N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2- methylpyrimidin-4-yl) amino] -1, 3 -thiazole-5 -carboxamide (90gm).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1780-26-3, its application will become more common.

Reference:
Patent; ALEMBIC PHARMACEUTICALS LIMITED; JAYARAMAN, Venkatraman; PATEL, Samir; MISTRY, Samir; PARMAR, Bhupendra; WO2015/49645; (2015); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some common heterocyclic compound, 504-17-6, molecular formula is C4H4N2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.504-17-6

General procedure: Nano-sawdust-OSO3H (0.02 g) was added to a stirred mixture of the aromatic aldehyde (1 mmol), malononitrile (1 mmol) and barbituric acid or thiobarbituric acid (1 mmol) in EtOH (5 mL). The materials were mixed and refluxed for the appropriate time. The progress of the reaction was followed by TLC (n-hexane:ethyl acetate 3:1). After completion of the reaction, the mixture was filtered to remove the catalyst. After evaporation of the solvent, the crude product was re-crystallized from hot ethanol to obtain the pure compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 504-17-6.

Reference:
Article; Sadeghi; Bouslik; Shishehbore; Journal of the Iranian Chemical Society; vol. 12; 10; (2015); p. 1801 – 1808;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

2380-63-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

Example 1 :Step 1 :To the solution of 3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-4-amine (5.4 g, 40.0 mmol) in DMF (100 mL) was added NIS (10.8 g, 48.0 mmol). The resulting mixture was then heated to 70C and stirred for 16 h. Poured into ice water, the solid was collected by filtration, and washed with saturated aqueous Na2C03 solution and water. After drying, the desired product was obtained as yellow solid (9.3 g, 77%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine.

Reference:
Patent; FUJIAN HAIXI PHARMACEUTICALS CO., LTD; KANG, Xinshan; WANG, Ruyong; ZHU, Xizhen; WO2015/18333; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

213265-83-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine, the common compound, a new synthetic route is introduced below.

To a stirred solution of 20.2 (120 mg, 0.000722 mol) in n-butanol (0.5 mL) was added NH4OH (1 mL). The reaction mixture was heated at 90 C. for 2.5 hr in a sealed tube. The reaction mixture was cooled to 0 C., and the resulting solid was filtered and dried under vacuum to give 20.3 (60 mg, 57%). 1H-NMR (DMSO-d6 500 MHz): delta 8.03 (s, 1H), 7.60 (s, 2H); m/z: 148 [M+1]+.

Statistics shows that 213265-83-9 is playing an increasingly important role. we look forward to future research findings about 4,6-Dichloro-5-fluoropyrimidine.

Reference:
Patent; Sunesis Pharmaceuticals, Inc.; US2009/36419; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

588-36-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 588-36-3, name is 4-Amino-5-hydroxymethyl-2-(methylthio)pyrimidine. A new synthetic method of this compound is introduced below.

To a solution of (4-amino-2-(methylthio)pyrimidin-5 -yl)methanol (11 g, 63 mmol, 1.0 equiv) in CHC13 (900 mL) was added Mn02 (43.85 g, 504 mmol, 8.0 equiv). The suspension was stirred overnight at rt. The resulting mixture was filtration and washing with CHC13. The filtrate was concentrated under vacuum to give 10 g (94%) of 4-amino-2-(methylthio)pyrimidine-5- carbaldehyde as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,588-36-3, 4-Amino-5-hydroxymethyl-2-(methylthio)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; PRINCIPIA BIOPHARMA, INC.; VERNER, Erik; BRAMELD, Kenneth Albert; WO2015/120049; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

156-81-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 156-81-0, name is Pyrimidine-2,4-diamine, the common compound, a new synthetic route is introduced below.

A solution of 2-bromo-1-(5-chloro-2,4-dimethoxyphenyl)ethanone 3 (140 mg, 0.47 mmol) and pyrimidine-2,4-diamine (50 mg, 0.45 mmol) in acetone (5 mL) was heated to reflux for 16 h. The reaction mixture was cooled to room temperature. The precipitate was filtered and treated with dilute ammonia. Precipitate was filtered, washed with water, and dried under reduced pressure to yield 2-(5-chloro-2,4- dimethoxyphenyl)imidazo[l,2-a]pyrimidin-7-amine 158b ( 95 mg, 36%) as a white solid. 1H NMR (300 MHz, DMSO-d6) delta 8.36 (d, 1H J = 7.2Hz), 8.09 (s, 1H). 7.76 (s, IH), 6.84 (s, IH), 6.76 (s, 2H), 6.22 (d, 1H, J = 7.2Hz), 3.98 (s, 3H), 3.92 (s, 3H); ESI MS m/z 305 [M+H]+

Statistics shows that 156-81-0 is playing an increasingly important role. we look forward to future research findings about Pyrimidine-2,4-diamine.

Reference:
Patent; ONCOTHERAPY SCIENCE, INC.; MATSUO, Yo; HISADA, Shoji; NAKAMURA, Yusuke; CHAKRABARTI, Anjan; RAWAT, Manish; RAI, Sanjay; SATYANARAYANA, Arvapalli, Venkata; DUAN, Zhiyong; TALUKDAR, Arindam; RAVULA, Srinivas; DECORNEZ, Helene; (491 pag.)WO2017/58503; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

1722-12-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1722-12-9, name is 2-Chloropyrimidine, molecular formula is C4H3ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 1; Pd(PPh3VNaHCO3DME/H,O/reflux [00203] 2,2-Dimethyl-N-(2-pyrimidin-2-yI-phenyI)-propionamide: A 5 L flask was charged with the above depicted boronic acid as a tetrahydrate (281.4 grams, 960 mmoles), 2- chloropyrimidine (100 g, 874 mmoles), NaHCO3 (146.8 grams, 1.746 moles), and Pd(PPh3)4 (10.0 grams, 8.72 mmoles). Water (IL) and dimethoxyethane (IL) were added, and the mixture was heated slowly to 83 0C (internal temperature) over a 1 hour period with overhead stirring. After ~2 hours all solids had dissolved. The reaction was allowed to stir for 8 hours. The mixture was cooled to room temperature and stirred overnight after which time a thick precipitate had formed. The crude mixture was diluted with water (2L) and stirred for an additional 2 hours after which time the mixture was filtered and the solids were washed sequentially with water, 0.1 N NaOH, and water again. The solids were then dried under high vacuum at 50 0C to afford the title compound (-233 grams) as a tan powder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1722-12-9, 2-Chloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2007/56330; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4212-49-1, name is 5-Ethyluracil, molecular formula is C6H8N2O2, molecular weight is 140.14, as common compound, the synthetic route is as follows.4212-49-1

Step A: Synthesis of 2,4-dichloro-5-ethylpyrimidine. To a suspension of 5-ethyluracil (1 g, 7.1 mmol) in POCl3 (4.5 mL) was slowly added N,N-dimethylaniline (1 mL). The reaction was heated at reflux (~120 C) for 5 h until the starting material was completely dissolved and the entire solution turned a purple color. The mixture was allowed to cool and poured very slowly into ice (~40 g). The resulting ppt was filtered and washed with ice water. The ppt was dissolved with a minimal amount of DCM and poured onto a short column of silica gel, and the product (1.2 g, ~ 100 %) was obtained by column chromatography with DCM. 1H NMR (400 MHz, CDCl3) delta 8.42 (s, 1 H), 2.75 (q, 2 H, J = 7.6 Hz), 1.29 (t, 3 H, J = 7.6 Hz).

Statistics shows that 4212-49-1 is playing an increasingly important role. we look forward to future research findings about 5-Ethyluracil.

Reference:
Patent; Taisho Pharmaceutical Co. Ltd.; Arena Pharmaceuticals, Inc.; EP1464335; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

36315-01-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 36315-01-2 as follows.

24.5g carbamate, 11.8g 4,6-dimethoxy-2-pyrimidinamine, 200mL tolueneMix and put into the reaction vessel and heat to reflux. After about 0.5h, start to collect the mixed solution of toluene and ethanol.Fresh toluene was added at the same speed, and the reaction was completed after refluxing for 5h. Stop adding toluene, distill off some toluene, cool to room temperature, and filter.After drying, 24.6 g of nicosulfuron was obtained, the mass fraction was 95.0%, and the yield was 75.6%.

The chemical industry reduces the impact on the environment during synthesis 36315-01-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Heilongjiang Suihua Farming Chenhuan Biological Preparation Co., Ltd.; Du Chuanyu; Zhao Mingxin; Jiang Yushan; Zhou Dewei; Wang Weisheng; (7 pag.)CN111269214; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5750-76-5, name is 2,4,5-Trichloropyrimidine, molecular formula is C4HCl3N2, molecular weight is 183.4231, as common compound, the synthetic route is as follows.5750-76-5

General procedure: To a solution of compound 15 (37.65 mmol) in 1,4-dioxane (50 mL) were added diisopropylethylamine (7.3 g, 56.48 mmol) and 2,4,5-trichloropyrimidine (6.9 g, 37.65 mmol) or 2,4-dichloro-5-fluoropyrimidine (6.3 g, 37.65 mmol). The reaction was heated to 60 C and stirred for 2 h. After being cooled to room temperature, the reaction mixture was added to water (300 mL). The precipitate was filtered, and the filtered cake was rinsed with additional cool water and dried in a vacuum oven to give the compound 16a,b (91%), which was used without further purification.

Statistics shows that 5750-76-5 is playing an increasingly important role. we look forward to future research findings about 2,4,5-Trichloropyrimidine.

Reference:
Article; Ge, Yang; Yang, Haijun; Wang, Changyuan; Meng, Qiang; Li, Lei; Sun, Huijun; Zhen, Yuhong; Liu, Kexin; Li, Yanxia; Ma, Xiaodong; Bioorganic and Medicinal Chemistry; vol. 25; 2; (2017); p. 765 – 772;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia