Tag: M.W=200-250

Adriaens, E. L.; Lozet, F. published the artcile< Fermented beverages of Ruanda natives>, Computed Properties of 3921-01-5, the main research area is .

The preparation of hydromel (I), and banana (II) and sorgho (III) beers is described. I contained before and after fermentation: dry extract 365.26-115.28, inorganic matter 10.78-6.20, total N 3.15-1.93, reducing sugars in glucose 250.0-66.11, sucrose 12.45-4.29, acidity as H2SO4 1.62-5.78 g./l.; in the wort: wax and sorgho yeast 86.9 g./l.; in the I EtOH 8.6°. Corresponding data for II were: 197.12-52.63, 11.14-9.87, trace-3.15, 93.74-19.16, 80.29-2.95, 3.28-4.21 g./l. and EtOH in the end product 9.46°. “”Inkanganza”” made from II with addition of honey and sorgho yeast gave, before and after fermentation: 149.2-52.88, 10.88-5.34, 5.08-3.75, 116.54-12.45, 11.91-4.33, 4.9-3.92 g./l., EtOH 11.5°. Wort of III and the end product contained: dry extract 172.9-256.8, inorganic 5.16-6.86, N 6.08-26.56, glucose 43.02-trace, sucrose 5.57-16.06, acids 2.11-5.98 g./l., EtOH 3.75°. Uryama, a III containing about 10% honey, gave: 244.83-136.24, 7.08-7.37, 10.68-3.15, 105.17-37.43, trace-0.0, 3.92-10.15 g./l., EtOH 6.4°.

Bull. Agr. Congo Belge published new progress about Beer. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Computed Properties of 3921-01-5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Zhang, Hongwang; Zhou, Longhu; Amichai, Sarah; Zandi, Keivan; Cox, Bryan; Schinazi, Raymond; Amblard, Franck published the artcile< Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection>, Application In Synthesis of 18740-39-1, the main research area is pimodivir derivative preparation influenza A infection polymerase PB2 inhibitor; Antiviral; Flu; Influenza A; Virus.

Exploration of the chem. space of known influenza polymerase PB2 inhibitor Pimodivir, was performed by our group. We synthesized and identified compounds I and II, two novel thienopyrimidine derivatives displaying anti-influenza A activity in the single digit nanomolar range in cell culture. Binding of these unique compounds in the influenza polymerase PB2 pocket was also determined using mol. modeling.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents (anti-influenza A). 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Application In Synthesis of 18740-39-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sandosham, Jessie; Undheim, Kjell published the artcile< Stannylation in the electrophilic 2- and 4/6-pyrimidine position and the use of stannylpyrimidines in coupling and tin-lithium exchange reactions>, Quality Control of 3921-01-5, the main research area is stannylation electrophilic pyrimidine lithio; stannylpyrimidine coupling acyl chloride bromide; tin lithium exchange reaction stannylpyrimidine; carbonyl compound coupling stannylpyrimidine.

2-Stannylpyrimidines have been prepared by stannyl anion substitution in 2-chloropyrimidines. Stannylation in the 4-position was via the iodo-derivative or via the 4-lithio derivative and lithium-tin transmetalation. Tin-lithium exchange in the 2-position resulted in 2-lithiopyrimidine. Ketones were formed from the stannylpyrimidines and acid chlorides, aryl bromides required Pd-catalysis for coupling reaction.

Tetrahedron published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Quality Control of 3921-01-5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mosavian, Seyed Yousef; Ebrahimi-Kahrizsangi, Reza; Khah, Mohammad Malakooti; Hamidi, Zeinab; Rafiei, Amin; Behzadi, Mohsen published the artcile< Effect of Mechanical Activation on the Kinetics of Silica Carbothermal Reduction in non-Isothermal Conditions>, Application of C4H2Br2N2, the main research area is silica carbothermal reduction non isothermal condition mech activation kinetics.

The effect of mech. activation on the synthesis temperature decreasing of silicon carbide was investigated and a kinetic model of a carbothermic reduction of silicon carbide was obtained. Silicon carbide was synthesized using silica activated in a planetary mill at different times up to 40 h under an argon atm. Structural changes due to the milling and the reduction of the activated silica were studied by the X-Ray diffraction (XRD) method and non-isothermal TGA with a heating rate of 10oC min-1 resp. The kinetic model obtained by the fitting technique for an unmilled sample was found to be chem. controlled of the second order with E = 138.92 Kcal.mol-1 and A =3.92×1015 s-1. For the sample milled up to 20 h, according to the Avrami-Erofeev3 equation; A = 1465633 s-1 and E = 66.71 Kcal.mol-1.

Silicon published new progress about Activation energy. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Application of C4H2Br2N2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Chen, Chen; Sun, Chengyu; Xu, Shan; Tu, Yuanbiao; Zheng, Pengwu; Zhu, Wufu published the artcile< Synthesis of one novel thieno[2,3-D]pyrimidine derivative bearing a sulfonylurea moiety>, Synthetic Route of 18740-39-1, the main research area is thieno pyrimidine sulfonylurea.

A novel thieno[2,3-d]pyrimidine compound (1) bearing a sulfonylurea moiety was synthesized from Me 2-aminothiophene-3-carboxylate (2) through five steps including cyclization, chlorination, substitution with morpholine and piperazine, amidation and its structure was confirmed by 1H NMR and MS spectrum. The total yield of the five steps was 16.2% (calculated from Me 2-aminothiophene-3-carboxylate).

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about Amidation. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Synthetic Route of 18740-39-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Zhang, Ning; Zheng, Caijun; Chen, Zhipeng; Zhao, Juewen; Zhang, Ming; Yang, Haoyu; He, Zeyu; Du, Xiaoyang; Tao, Silu published the artcile< Improving the efficiency of exciplex based OLEDs by controlling the different configurations of the donor>, Synthetic Route of 3921-01-5, the main research area is organic light emitting diode efficiency donor configuration.

Two D-A-D type donor materials, 10,10′-(pyridine-2,4-diyl)bis(9,9-dimethyl-9,10-dihydroacridine) (Pra-2DMAC) with vertical mol. conformation and 10,10′-(pyrimidine-2,4-diyl)bis(9,9-dimethyl-9,10-dihydroacridine) (Prm-2DMAC) with near-planar mol. conformation, were designed and synthesized in order to develop the performance of exciplex based OLEDs. Pra-2DMAC shows a better performance than Prm-2DMAC, due to its vertical configuration, which has a beneficial effect on exciplex emission because the separated HOMO and LUMO in donor facilitates the intramol. charge transfer (ICT) and reverse intersystem crossing (RISC) process at the excited state. An exciplex device with a simple structure based on Pra-2DMAC shows a high maximum external quantum efficiency (EQE) of 15.0% (13.9% at 1000 cd m-2), low turn-on voltage of 2.4 V, and stable electroluminescence spectrum of nearly constant CIE coordinate. The better performance of Pra-2DMAC demonstrates the superiority of the donor with vertical configurations in an exciplex system. To our knowledge, this is the first work to study exciplex based OLEDs using dual configuration donor materials.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Cyclic voltammetry. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Synthetic Route of 3921-01-5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Woodring, Jennifer L.; Bachovchin, Kelly A.; Brady, Kimberly G.; Gallerstein, Mitchell F.; Erath, Jessey; Tanghe, Scott; Leed, Susan E.; Rodriguez, Ana; Mensa-Wilmot, Kojo; Sciotti, Richard J.; Pollastri, Michael P. published the artcile< Corrigendum to ""Optimization of physicochemical properties for 4-Anilinoquinazoline inhibitors of trypanosome proliferation"" [Eur. J. Med. Chem. 141 (2017) 446-459] [Erratum to document cited in CA167:595582]>, Recommanded Product: 2,4-Dibromopyrimidine, the main research area is anilinoquinazoline trypanosome inhibitor antimalarial malaria trypanosomiasis trypanosomicide erratum.

In the original publication, the acknowledgments section has information omitted; the correction is provided here.

European Journal of Medicinal Chemistry published new progress about Antimalarials. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Recommanded Product: 2,4-Dibromopyrimidine.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Dexheimer, Thomas S.; Rosenthal, Andrew S.; Luci, Diane K.; Liang, Qin; Villamil, Mark A.; Chen, Junjun; Sun, Hongmao; Kerns, Edward H.; Simeonov, Anton; Jadhav, Ajit; Zhuang, Zhihao; Maloney, David J. published the artcile< Synthesis and Structure-Activity Relationship Studies of N-Benzyl-2-phenylpyrimidin-4-amine Derivatives as Potent USP1/UAF1 Deubiquitinase Inhibitors with Anticancer Activity against Nonsmall Cell Lung Cancer>, Safety of 2,4-Dichlorothieno[2,3-d]pyrimidine, the main research area is benzylphenylpyrimidinamine antitumor neoplasm deubiquitinase.

Deregulation of ubiquitin conjugation or deconjugation has been implicated in the pathogenesis of many human diseases including cancer. The deubiquitinating enzyme USP1 (ubiquitin-specific protease 1), in association with UAF1 (USP1-associated factor 1), is a known regulator of DNA damage response and has been shown as a promising anticancer target. To further evaluate USP1/UAF1 as a therapeutic target, the authors conducted a quant. high throughput screen of >400000 compounds and subsequent medicinal chem. optimization of small mols. that inhibit the deubiquitinating activity of USP1/UAF1. Ultimately, these efforts led to the identification of ML323 (70) and related N-benzyl-2-phenylpyrimidin-4-amine derivatives, which possess nanomolar USP1/UAF1 inhibitory potency. Moreover, the authors demonstrate a strong correlation between compound IC50 values for USP1/UAF1 inhibition and activity in nonsmall cell lung cancer cells, specifically increased monoubiquitinated PCNA (Ub-PCNA) levels and decreased cell survival. The results establish the druggability of the USP1/UAF1 deubiquitinase complex and its potential as a mol. target for anticancer therapies.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Safety of 2,4-Dichlorothieno[2,3-d]pyrimidine.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Zhi, Yanle; Li, Baoquan; Yao, Chao; Li, Hongmei; Chen, Puzhou; Bao, Jiyin; Qin, Tianren; Wang, Yue; Lu, Tao; Lu, Shuai published the artcile< Discovery of the selective and efficacious inhibitors of FLT3 mutations>, Quality Control of 18740-39-1, the main research area is pyrazole carboxamide preparation FLT3 inhibitor mutation antitumor leukemia; AML; Acute myeloid; FLT3; FMS-Like tyrosine kinase 3 inhibitors; Leukemia.

Fms-like tyrosine kinase 3 (FLT3) is among the most frequently mutated protein in acute myeloid leukemia (AML), which has been confirmed as an important drug target for AML chemotherapy. Starting from the lead compound LT-106-175, a series of 1-H-pyrazole-3-carboxamide derivatives were synthesized to improve the FLT3 inhibitory potency and selectivity. Among them, compound 50 (4-((2-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide) was identified as a highly potent and selective FLT3 inhibitor (IC50 = 0.213 nM), which showed equal activities against various mutants of FLT3 including FLT3 (ITD)-D835V and FLT3 (ITD)-F691L that is resistant to quizartinib. Compound 50 also exhibited efficacy against the human AML cell line MV4-11 (IC50 = 16.1 nM) harboring FLT3-ITD mutants. Inversely, compound 50 displayed no cytotoxicity to FLT3-independent cells, and the biochem. analyses showed that its effects were related to the inhibition of FLT3 signal pathways. Addnl., compound 50 induced apoptosis in MV4-11 cell as demonstrated by flow cytometry. Moreover, compound 50 showed enhanced metabolic stability. Altogether, it was concluded that compound 50 could be a promising FLT3 inhibitor for further developing therapeutic remedy of AML.

European Journal of Medicinal Chemistry published new progress about Acute myeloid leukemia. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Quality Control of 18740-39-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ife, Robert J.; Brown, Thomas H.; Blurton, Peter; Keeling, David J.; Leach, Colin A.; Meeson, Malcolm L.; Parsons, Michael E.; Theobald, Colin J. published the artcile< Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 5. Substituted 2,4-Diaminoquinazolines and Thienopyrimidines>, Related Products of 18740-39-1, the main research area is quinazolinamine thienopyrimidinamine quinazolinediamine.

Quinazolines bearing a secondary [4-(arylamino)] substituent demonstrate a structure-activity relationship for inhibition of the gastric (H+/K+)-ATPase different from the previously described 3-acylquinolines, suggesting that, although these compounds are also K+-competitive, they probably bind to the enzyme in a different orientation. Compounds bearing a tertiary 4-(arylamino) substituent, however, in particular 4-(N-methylarylamino), appear to possess an structure-activity relationship quite similar to the 3-acylquinolines. Compounds possessing both a 4-(N-methylarylamino) substituent and a 2-(arylamino) substituent proved to be very potent, K+-competitive inhibitors of K+-stimulated ATPase activity with Ki values down to 12 nM. Some compounds also proved to be effective inhibitors of stimulated acid secretion in both the rat and dog when dosed i.v. However, although a number of these demonstrated activity after oral administration in dogs, the level and variability precluded further evaluation.

Journal of Medicinal Chemistry published new progress about Structure-activity relationship, ATPase-inhibiting. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Related Products of 18740-39-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia