Tag: M.W=400-500

Related Products of 1421372-67-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1421372-67-9, name is N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine, molecular formula is C25H29N7O3, molecular weight is 475.5429, as common compound, the synthetic route is as follows.

A solution of N1- (2- (dimethylamino) ethyl) -5-methoxy-N1-methyl-N4- (4- (1-methylindol-3-yl) 2-nitrophenyl-1,4-diamine (30.0 g, 0.063 mol) was added to a 1 L vial,Adding 600 mL of tetrahydrofuran and 10 g of Raney nickel,Hydrogen gas at a pressure of 3 atm was introduced at room temperature,Reaction for 12 h.After the reaction is complete,The reaction solution was filtered through celite,To obtain a brown solution,Concentrated under reduced pressure to give crude brown solid,The crude product was purified by recrystallization from 250 mL of a mixture of ethyl acetate and n-heptane (1: 1 by volume of ethyl acetate and n-heptane in the mixture)To give a light brown solid N1- (2- (dimethylamino) ethyl) -5-methoxy -N1- methyl -N4- (4- (1- methyl-indol-3-yl) pyrimidine-2 – yl) phenyl-1,2,4-triamine 21.9g, yield 78%.

Statistics shows that 1421372-67-9 is playing an increasingly important role. we look forward to future research findings about N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine.

Reference:
Patent; Shanghai University of Engineering Science; Zhu, Guoqing; Mao, Yongjun; Zhu, Chunping; Wang, Han; (16 pag.)CN106366072; (2017); A;,
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Pyrimidine – Wikipedia

Reference of 139756-22-2 ,Some common heterocyclic compound, 139756-22-2, molecular formula is C17H19ClN4O4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Using the procedure described in Example 1, the reaction solvent and proton scavenger were varied.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 139756-22-2, 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2005/67936; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
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Synthetic Route of 799842-07-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 799842-07-2, name is N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide. This compound has unique chemical properties. The synthetic route is as follows.

The organic layer was concentrated at a temperature in the range of from about 60 C. to about 70 C. under reduced pressure. The white solid obtained was then added to toluene (300 ml) at a temperature of about 25 C. Tri-n-butyl phosphine was then slowly added. After about 20 to about 25 minutes, a bright white solid falls out and is filtered and washed with toluene (100 mL). The solid was then dried in an oven at a temperature below about 50 C. until the moisture content was about 1%. The dried solid appeared as a white crystalline solid weighing about 29 g to about 29.5 g. The yield was about 97% to about 99%, having a mp 180-182 C., and a purity greater than 99% as determined by HPLC. The IR (KBr) spectrum shows the absorption bands at cm-1 2962 (C-H str), 1604 (-CC-str), 1155 (SO2 str). The 1H-NMR (DMSO-d6) shows delta7.8-7.9[dd,2H,Ar-H], 7.4-7.5[t,2H,Ar-H], 4.0[d,2H,CH2P],3.4-3.5 [2×s,6H,NCH3,SO 2CH3], 3.41 [m,1H,CH(CH3)2], 1.9-2.0[t,6H,P-(CH2)],1.10-1.29 [m,18H, -(CH2)3-] 0.81[t,9H,(CH2-CH3)3]. The CI mass shows m/z 538.4 (base peak). The elemental analysis calculated % C 54.36; % H 7.49; % N 6.79; Observed % C 54.30; % H 7.41, % N 6.72.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 799842-07-2, N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide.

Reference:
Patent; Joshi, Narendra; Bhirud, Shekhar Bhaskar; Chandrasekhar, Batchu; Rao, K. Eswara; Damle, Subhash; US2005/124639; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
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Application of 147118-39-6 ,Some common heterocyclic compound, 147118-39-6, molecular formula is C23H28FN3O6S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a round bottom flask 2000 ml Tetrahydrofuran (THF) was added under the nitrogen atmosphere and cooled to -90°C then 1Og sodium borohydride was added followed by 230ml diethylmethoxyborane (1 M solution in THF) in 90-120mins. In this reaction mass, mixture of lOOg of Methyl -7-[4-(4-fiourophenyl)-6-isopropyl-2-(N-methyl-N- methylsulfonylaniino)-pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenate5 700 ml THF and 700 ml methanol was added for a duration of 90-120min then stirred for 2 hrs at -90 to -80°C. After the completion of reaction, 124 ml acetic acid was added and stirred for 30-60 min at same temperature. Above reaction mass was diluted with 1500ml ethyl acetate and washed with brine solution. To the organic layer, 500 ml DM water was added and pH was adjusted to neutral by ~ 500 ml 6 percent sodium bicarbonate solution. Both the layers were separated Sc the organic layer was dried over sodium sulphate. The organic layer was concentrated at 40-450C. Above concentrated mass was diluted with 900ml ethyl alcohol and then cooled to 0°C. Sodium hydroxide solution was added in 60- 90 min. The reaction mass was stirred for 30 min at room temperature and the pH was adjusted to 11.5-12.0 by using ~ 4 percent sodium hydroxide solution. In this reaction mass, 1Og activated carbon was added and stirred for 20 min. The reaction mass was filtered and washed with ethanol/DM water mixture. The reaction mass was concentrated up to thick residue at 40-45°C. To this concentrated mass, 500 ml DM water was added followed by 1000ml ethyl acetate and the pH was adjusted to 3.5- 4.0 with 1:4 aqueous hydrochloric acid. Both the layers were separated and the organic layer was washed with brine solution.The organic layer was dried over sodium sulphate and concentrated till dryness at 40-45°C. To the above concentrated mass, 1000 ml acetonitrile was added stirred at room temperature for half an hour. Slowly 20.5 g (S)-2-amino-3, 3 -dimethyl butane was added and stirred for almost 2 hrs. The solid was filtered and washed with acetonitrile and diisopropyl ether. Finally the solid was dried for 6-9 hrs at 40-45°C.Above obtained (S)-2-amino-3, 3 -dimethyl butane salt of rosuvastatin was suspended in 1000 ml isopropanol followed by 100 ml methanol. This reaction mass was heated for half an hour at 60-80°C then stirred for 3-4 hrs at 5-1O0C. The solid was filtered washed with isopropanol and diisopropyl ether. 95 gms of (S)-2-amino-3, 3 -dimethyl butane salt of rosuvastatin was obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 147118-39-6, 5-Oxorosuvastatin methyl ester, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MATRIX LABORATORIES LTD; SETHI, Madhuresh, Kumar; MAHAJAN, Sanjay; MARA, Bhairaiah; AYYARAN, Laxmi, Karthikeyan; DATTA, Debashish; WO2010/35284; (2010); A2;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 147118-40-9, name is Rosuvastatin methyl ester. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Rosuvastatin methyl ester

The synthetic route is shown in flow diagram 4:The detailed preparing process is as follows:150mL acetonitrile and 18g (3R,5S,6E)-7-[4-(4-flurophenyl)-6-(1-methyl ethyl)-2-[methyl (methyl sulfonyl) amino]-5-pyrimidyl]-3,5-dihydroxy-6-methyl heptenoate were added to a 500mL reaction flask.Once the product was fully dissolved, 40mL purified water was added and the mixture was heated to 40°C.Subsequently, 42mL 1N sodium hydroxide solution was added at constant speed, wherein the addition process took around 15 minutes, and then the mixture was reacted at 40°C for 2.5 hours.The obtained solution was vacuum distilled to remove acetonitrile at 45°C, 30mL water was then added, and the mixture was cooled to 30°C with ice water.The mixture was washed three times with ethyl ether (50mL each time), wherein it was stirring for 15 minutes during each washing, the obtained mixture was allowed to stand for layering, and the water phase was collected.Then 3g activated carbon was added, the mixture was heated to 40°C and stirred for 60 minutes, the obtained mixture was filtered, the filter cake was washed with 10mL purified water, the filtrate and washing solution were combined and cooled to 20°C, and then 90mL ethyl ether was added.The pH value was adjusted to 5 with 0.5N hydrochloric acid, the mixture was stirred for 15 minutes and allowed to stand for layering for 15 minutes.The water phase was extracted twice with ethyl ether (60mL each time), wherein it was stirring for 15 minutes during each extraction, and then was allowed to stand for layering.The organic phases were combined and washed twice with saturated sodium chloride solution (60mL each time) and then allowed to stand for layering.The water phase was removed, while 6g anhydrous sodium sulfate was added to the organic phase and stirred for 35 minutes.The obtained mixture was filtered to remove anhydrous sodium sulfate, the filtrate was vacuum distilled to remove ethyl ether at 30°C, then 50g DMF and 2.5g K2CO3 were added.The mixture was vacuum distilled for 1.5 hours at 30°C to remove ethyl ether.As a result, 69.6g DMF solution containing (3R,5S,6E)-7-[4-(4-flurophenyl)-6-(1-methyl ethyl)-2-[methyl (methyl sulfonyl) amino]-5-pyrimidyl]-3,5-dihydroxy-6-heptonic acid was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 147118-40-9, Rosuvastatin methyl ester.

Reference:
Patent; Changzhou Pharmaceutical Factory; EP2298745; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 139756-22-2 ,Some common heterocyclic compound, 139756-22-2, molecular formula is C17H19ClN4O4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Using the procedure described in Example 1, the reaction solvent and proton scavenger were varied.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 139756-22-2, 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2005/67936; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 799842-07-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 799842-07-2, name is N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide. This compound has unique chemical properties. The synthetic route is as follows.

The mass fraction is 10% by weight aqueous sodium hydroxide solution, 5-bromomethyl-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine,Methanol, tridecyl-s-triazine is mixed and heated to 40 C.The reaction was kept for 15 hours, the pH was adjusted to neutral with a mass fraction of 5 wt% aqueous hydrochloric acid, and the methanol was concentrated to remove.The organic phase is extracted with ethyl acetate, dried over anhydrous sodium sulfate,The molar ratio of 5-bromomethyl-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine, tridecyl-triazine, sodium hydroxide is 3.05 :1:3.3,The weight-volume (g/ml) ratio of 5-bromomethyl-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine and methanol is 416:3000. ;

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 799842-07-2, N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide.

Reference:
Patent; Anhui Qingyun Pharmaceutical Co., Ltd.; Huang Huan; Huang Qingyun; Li Kai; Zhang Hongyuan; (12 pag.)CN109574938; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 607740-08-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 607740-08-9, name is 4-(3,5-Dibromophenyl)-2,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

In the argon atmosphere,Intermediate A (4.4 g, 21 mmol) synthesized according to the method described in JP-A-2010-180204,Intermediate B (4.7 g, 10 mmol) according to the method described in International Publication No. 2003/080760,(Dibenzylideneacetone) dipalladium (0.37 g, 0.4 mmol)Tri-butyl-tetrafluoroborate (0.46 g, 1.6 mmol)Sodium butoxide (2.7 g, 28 mmol)Anhydrous toluene (100 mL),And heated to reflux for 8 hours.After the reaction solution was allowed to cool to room temperature,Separating the organic layer,The organic solvent was distilled off under reduced pressure.The resulting residue was purified by silica gel column chromatography,The title compound GH-4 (3.6 g, yield 50%) was obtained.

According to the analysis of related databases, 607740-08-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; Ogiwara, Toshinari; Hosokawa, Chishio; (82 pag.)TW2016/38086; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 147118-39-6, name is 5-Oxorosuvastatin methyl ester. A new synthetic method of this compound is introduced below., Recommanded Product: 147118-39-6

S3: Under nitrogen protection, 110 g of tetrahydrofuran and 27.5 g of methanol were added to the reaction flask, the temperature was lowered to -80 ± 5 ° C, 3.19 g of sodium borohydride was added, and the mixture was stirred for 15 minutes, and the temperature was controlled to -80 ± 5 ° C, and 49.5 g was added dropwise. The solution of percentEt2BOMe in tetrahydrofuran was diluted for 1 h. After the end of the incubation, 15.84 g of the S2 product in tetrahydrofuran solution was added dropwise, and the dropping temperature was controlled to -80 ± 5 ° C. After 4 h, the temperature was raised to 4.5 h and the temperature was raised to 20-25 ° C, then adjusted with glacial acetic acid PH = 6.0-7.0, stirred for 30 minutes, re-test PH = 6.0-7.0 qualified, concentrated to dryness under reduced pressure, the end of concentration, then add ethyl acetate and water to stir and dissolve The mixture was allowed to stand for stratification, and the water layer was discarded. The organic layer was washed once with saturated brine, and the organic layer was collected. The organic layer was concentrated at 45 ° C to give an oil (3R, 5S)-7-[4-(4-fluorobenzene) Methyl-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3,5-dihydroxy-6(E)-heptenoic acid methyl ester 15.8 g ;

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 147118-39-6, 5-Oxorosuvastatin methyl ester.

Reference:
Patent; Suzhou Zhonglian Chemical Pharmaceutical Co., Ltd.; Hu Liyong; Liu Yaowu; Huang Junhao; Zhang Bo; Zhou Zijin; (10 pag.)CN108586358; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
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Adding a certain compound to certain chemical reactions, such as: 125401-75-4, 2,6-Bis((4,6-dimethoxypyrimidin-2-yl)oxy)benzoic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2,6-Bis((4,6-dimethoxypyrimidin-2-yl)oxy)benzoic acid, blongs to pyrimidines compound. Quality Control of 2,6-Bis((4,6-dimethoxypyrimidin-2-yl)oxy)benzoic acid

EXAMPLE 8 Ammonium 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoate (Compound No. 22) 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid (5.1 g) and 28% aqueous ammonia (1.7 g) were mixed with a solvent mixture of THF/ethanol. Precipitated crystals were washed with acetone to obtain the above identified compound as white crystals (3.7 g). (Melting point: 135-140 C.

The synthetic route of 125401-75-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kumiai Chemical Industry Co., Ltd.; Ihara Chemical Industry Co., Ltd.; US4906285; (1990); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia