Tag: M.W=400-500

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Ramadan, Mohamed, once mentioned the application of 139756-22-2, Name is 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride, molecular formula is C17H19ClN4O4S, molecular weight is 410.8752, MDL number is MFCD09753597, category is pyrimidines. Now introduce a scientific discovery about this category, Safety of 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride.

Design and synthesis of new pyranoquinolinone heteroannulated to triazolopyrimidine of potential apoptotic antiproliferative activity

Pyrano[3,2-c]quinoline derivatives have been synthesized and utilized to obtain various new hetero-annulated triazolopyrimidine, containing quinoline, pyran, 1,2,4-triazine and pyrimidine in good yields. Newly synthesized compounds have been characterized by spectral data and elemental analysis. Most of the synthesized compounds showed moderate to weak antiproliferative activity on most cancer cell lines, especially leukemia and breast cancer cell lines. The open chain formimidic acid ethyl ester is slightly more potent than heteroannulated systems. The most active compounds were further investigated for caspase activation, Bax activation and Bcl-2 down regulation compared to doxorubicin as a standard, and indeed exhibited mainly cell cycle arrest at the Pre-G1 and G2/M phases. The transcription effects of 5a and 5b on the p53 were assessed and compared with the reference doxorubicin. The results revealed an increase of 12-19 in p53 level compared to the test cells and that p53 protein level of 5a and 5b was significantly inductive (991, and 639 pg/mL, respectively) in relation to doxorubicin (1263 pg/mL)

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 139756-22-2, Safety of 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Synthetic Route of 139756-22-2, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 139756-22-2, Name is 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride, SMILES is O=S(C1=CC=C(OCC)C(C2=NC3=C(N(C)N=C3CCC)C(N2)=O)=C1)(Cl)=O, belongs to pyrimidines compound. In a article, author is Mekky, Ahmed E. M., introduce new discover of the category.

Bis(benzofuran-enaminone) hybrid possessing piperazine linker: Versatile precursor for microwave assisted synthesis of bis(pyrido[2 ‘,3 ‘:3,4]pyrazolo[1,5-a]pyrimidines)

We reported herein efficient procedures for the synthesis of new piperazine-linked bis(pyrido[2′,3’:3,4]pyrazolo[1,5-a]pyrimidines) using bis(benzofuran-enaminone) hybrid as a key intermediate. For this purpose, bis(enaminone) were reacted with a new series of 3-amino-4-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridines in pyridine under microwave irradiation at 120 degrees C for 90 min to afford the target bis(pyrimidines). In a two-steps synthetic route, bis(enaminone) was used to prepare a novel bis(3-amino-1H-pyrazolo[3,4-b]pyridine). Next, the former hybrid was reacted with two equivalents of the appropriate enaminones as well as arylidinemalononitriles in pyridine under microwave irradiation at 120 degrees C for 2 h to afford the target bis(pyrimidines). Furthermore, a mixture of bis(pyrazolopyridine) reacted with two equivalents of 1,3-diketones and beta-ketoesters in glacial acetic acid was microwave irradiated at 130 degrees C for 90 min to give bis(2,4-disubstituted pyrimidines) and bis(2-substituted pyrimidin-4(1H)-ones), respectively. The structures of the new hybrids were confirmed via considering their elemental analyses as well as their spectral data. [GRAPHICS] .

Synthetic Route of 139756-22-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 139756-22-2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is an experimental science, Application In Synthesis of 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 139756-22-2, Name is 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride, molecular formula is C17H19ClN4O4S, belongs to pyrimidines compound. In a document, author is Masjedi-Arani, Maryam.

Glioma cells eradication by photoexcitation of bioengineered molybdenum trioxide nanoparticles synthesized by wet chemical and microwave route: Dose dependent photosensitizer bioactivity

Here, we surveyed the usage of MoO3 nanostructure in role of a photosensitizer to eradicate glioma cells. This is the first endeavor upon survey of usage of nanostructured MoO3 to treat glioma in vitro. Here, we offer a simple way for preparation of bioactive MoO3 nanostructure via two different routes; wet chemical and microwave. The influence of diverse experimental factors like various alcoholic solvents and presence of capping agent was investigated on the final properties of synthesized products. Dimension and morphology of inorganic molybdenum trioxide nanostructures checked with TEM, HRTEM and also SEM images. Moreover, the cytotoxicity effect of optimized MoO3 nanoparticles was investigated on T98 and A172 cell lines. Both T98 and A172 cell lines indicated dose-dependent manner in the presence of increasing concentration of MoO3 nanostructures, but T98 cells were less sensitive to MoO3 in comparison with A172. Anti-glioma role of MoO3 nanostructures excited with the aid of UVC illumination studied in vitro as well. By studying the UV exposure lonely, it is evident that UV effects on cell viability about 50% in both cell lines after 24 h. Interestingly, by combining nanostructured MoO3 with UVC illumination, decrement in the proliferation value could be remarkably occurred in comparison with controls. The outcomes denote that the photodynamic therapy with the help of nanostructured MoO3 may be beneficial to treat glioma.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 139756-22-2, in my other articles. Application In Synthesis of 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

139756-22-2, Name is 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride, molecular formula is C17H19ClN4O4S, belongs to pyrimidines compound, is a common compound. In a patnet, author is Kalampalidis, Alexandros, once mentioned the new application about 139756-22-2, Recommanded Product: 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride.

Antithrombotic and antiplatelet activity of an organometallic rhodium(I) complex incorporating a substituted thieno-[2,3-d]-pyrimidine ligand: Synthesis, structural characterization, and molecular docking calculations

The antiplatelet and antithrombotic activity of a novel organometallic rhodium(I) complex of the formula [Rh(cod)Cl(tpc)] (1) (cod = cis-1,5-cyclooctadiene; tpc = methyl 2-amino-4-(diethylamino)-thieno-[2,3-d]-pyrimidine-6-carboxylate) was investigated. Complex 1 was easily synthesized by a one-pot, high-yield reaction and was fully characterized by standard spectroscopic techniques including FT-IR, UV-Vis, and NMR spectroscopy and by elemental analysis. The molecular structures of tpc and 1 were determined by single-crystal X-ray crystallography. Complex 1 displayed a slightly distorted square planar geometry and is the first crystallographically characterized example of a coordination compound bearing the ligand precursor tpc. Biological studies demonstrate that 1 displays strong antiplatelet and antithrombotic properties in vitro, by inhibiting both the aggregation of human and washed rabbit platelets induced by the potent inflammatory and thrombotic mediator, platelet-activating factor (PAF) in the micromolar range. This is an approach of continuous interest in the field. Molecular docking calculations suggest that 1 can fit at the ligand-binding site of the PAF receptor (PAFR) and thus block PAF thrombotic activities, through an antagonistic effect on the PAF/PAFR-related pathway, which is in accord with the experimental findings. Complex 1 constitutes an interesting example of a metal-based PAF inhibitor with promising antiplatelet, antithrombotic, and anti-inflammatory activity, because PAF is the most potent inflammatory lipid mediator. This is also supported by the fact that 1 is an inhibitor of other inflammatory and thrombotic mediators like thrombin, along with well-established platelet agonists like ADP and collagen.

If you¡¯re interested in learning more about 139756-22-2. The above is the message from the blog manager. Recommanded Product: 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Electric Literature of 139756-22-2, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 139756-22-2, Name is 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride, SMILES is O=S(C1=CC=C(OCC)C(C2=NC3=C(N(C)N=C3CCC)C(N2)=O)=C1)(Cl)=O, belongs to pyrimidines compound. In a article, author is Mock, Elliot D., introduce new discover of the category.

Structure-Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of N-Acylphosphatidylethanolamine Phospholipase D

N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is regarded as the main enzyme responsible for the biosynthesis of N-acylethanolamines (NAEs), a family of bioactive lipid mediators. Previously, we reported N-(cyclopropylmethyl)-64(S)-3-hydroxypyrroli din-1-yl)-2-((S)-3-phenylpiperidin-1-yl)pyrimidine-4-carboxamide (1, LEI-401) as the first potent and selective NAPE-PLD inhibitor that decreased NAEs in the brains of freely moving mice and modulated emotional behavior [Mock et al. Nat Chem. Biol., 2020, 16, 667-675]. Here, we describe the structure-activity relationship (SAR) of a library of pyrimidine-4-carboxamides as inhibitors of NAPE-PLD that led to the identification of LEI-401. A high-throughput screening hit was modified at three different substituents to optimize its potency and lipophilicity. Conformational restriction of an N-methylphenethylamine group by replacement with an (S)-3-phenylpiperidine increased the inhibitory potency 3-fold. Exchange of a morpholine substituent for an (S)-3-hydroxypyrrolidine reduced the lipophilicity and further increased activity by 10-fold, affording LEI-401 as a nanomolar potent inhibitor with drug-like properties. LEI-401 is a suitable pharmacological tool compound to investigate NAPE-PLD function in vitro and in vivo.

Electric Literature of 139756-22-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 139756-22-2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 139756-22-2, Name is 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride, SMILES is O=S(C1=CC=C(OCC)C(C2=NC3=C(N(C)N=C3CCC)C(N2)=O)=C1)(Cl)=O, in an article , author is Yang, Yang, once mentioned of 139756-22-2, Quality Control of 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride.

Metabolomics study of cerebrospinal fluid from diabetic rats with cognitive impairment simultaneously treated with Panax quinquefolius and Acorus gramineus

A metabolomics approach was used to explore the effects of Panax quinquefolius (PQ) and Acorus gramineus (AG) on learning and memory in rats with diabetic-induced cognitive impairment. Thirty Wistar rats were divided into three groups, namely, the normal group, model group, and PQ-AG group (PQ-AG group, 1.80 g/kg/d). Diabetes was induced by intraperitoneal injection of streptozotocin (65 mg/kg). Cerebrospinal fluid (CSF) was collected via cisterna magna puncture, and the Morris water maze method was used to evaluate learning and memory in rats after 11 weeks of PQ-AG treatment. Metabolic profiling of CSF samples was performed by using UPLC-Q-TOF-MS. Compared with the normal group, the escape latency of the Morris water maze was significantly prolonged in model group rats after 12 weeks (p < 0.01). Compared with the model group, however, the escape latency was significantly shortened in PQ-AG group rats (p < 0.05). In multivariate statistical analysis, we identified 33 potential biomarkers, and six biomarkers were altered by PQ-AG. These biomarkers were involved in the metabolism of pyrimidine; nicotinate, and nicotinamide; glycine, serine, and threonine; and ascorbate and aldarate. Taken collectively, our results indicate that PQ-AG can attenuate diabetic-induced cognitive impairment by affecting a variety of metabolic pathways. Our results provide an experimental basis for studying the mechanism of action of PQ-AG. Interested yet? Read on for other articles about 139756-22-2, you can contact me at any time and look forward to more communication. Quality Control of 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

139756-22-2, Name is 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride, molecular formula is C17H19ClN4O4S, belongs to pyrimidines compound, is a common compound. In a patnet, author is Muruzabal, Damian, once mentioned the new application about 139756-22-2, Safety of 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride.

The enzyme-modified comet assay: Past, present and future

The enzyme-modified comet assay was developed in order to detect DNA lesions other than those detected by the standard version (single and double strand breaks and alkali-labile sites). Various lesion-specific enzymes, from the DNA repair machinery of bacteria and humans, have been combined with the comet assay, allowing detection of different oxidized and alkylated bases as well as cyclobutane pyrimidine dimers, mis-incorporated uracil and apurinic/apyrimidinic sites. The enzyme-modified comet assay has been applied in different fields – human biomonitoring, environmental toxicology, and genotoxicity testing (both in vitro and in vivo) – as well as in basic research. Up to now, twelve enzymes have been employed; here we describe the enzymes and give examples of studies in which they have been applied. The bacterial formamidopyrimidine DNA glycosylase (Fpg) and endonuclease III (EndoIll) have been extensively used while others have been used only rarely. Adding further enzymes to the comet assay toolbox could potentially increase the variety of DNA lesions that can be detected. The enzyme-modified comet assay can play a crucial role in the elucidation of the mechanism of action of both direct and indirect genotoxins, thus increasing the value of the assay in the regulatory context.

If you¡¯re interested in learning more about 139756-22-2. The above is the message from the blog manager. Safety of 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reference of 799842-07-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 799842-07-2 as follows.

General procedure: Aq 1 M NaOH (9 mL, 1.5 equiv) was added to a stirred MeOH (20mL) solution of the appropriate aromatic thiol (7.2 mmol, 1.2equiv). The solution was stirred at r.t. for 15 min and then the heterocyclicalkyl bromide 2 or 3 (6 mmol, 1 equiv) was added. When rosuvastatin moiety bromides 2 were used, THF (10 mL) was also added to the mixture to improve solubility. After 18 h, the solvent was evaporated, the residue was dissolved in CH2Cl2 (50 mL), and washed with H2O (100 mL). The aqueous phase was additionally extracted with CH2Cl2 (2 ¡Á 25 mL). The combined organic phases were dried (MgSO4) and the solvent was evaporated. The residuewas recrystallized and the isolated product was dried in vacuumovernight at 60 C below 50 mbar to give the pure sulfide heterocyclic precursor 4 or 5 in 75-97% yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,799842-07-2, its application will become more common.

Reference:
Article; Fabris, Jan; ?asar, Zdenko; Smilovi?, Ivana Gazi?; ?rnugelj, Martin; Synthesis; vol. 46; 17; (2014); p. 2333 – 2346;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 147118-40-9, Rosuvastatin methyl ester, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Rosuvastatin methyl ester, blongs to pyrimidines compound. Recommanded Product: Rosuvastatin methyl ester

Add 150 ml of acetonitrile to the 500 ml reaction flask and add 18.0 g of RSM. After completely dissolving, 40 ml of purified water was added and heated to 35 ¡ã C to 40 ¡ã C. 42 ml of 1N sodium hydroxide solution was added dropwise to control the dropping rate Keep the temperature between 35 ~ 40 , the entire drop process takes about 10 ~ 15min, continue to react and then need 2 to 2.5 hours.The reaction was completed at 40 ¡ã C to 50 ¡ã C under reduced pressure to remove the acetonitrile organic solvent and then 30 ml of purified water was added to open the jacketed cooling water to lower the temperature of the contents to 25 ¡ã C to 30 ¡ã C and washed with ether 3 times, each with ether 50 ml, each stirring 10 ~ 15min, static liquid separation, collecting water layer.Then add 3 g of activated carbon in the water layer, heating to maintain the temperature 35 ~ 40 , stirring 50 ~ 60min, filter, filter with 10 ml of purified water filter cake, combined filtrate and lotion, the filtrate was vacuum distillation RSA 19.0 g

At the same time, in my other blogs, there are other synthetic methods of this type of compound,147118-40-9, Rosuvastatin methyl ester, and friends who are interested can also refer to it.

Reference:
Patent; Nanjing Ouxin Pharmaceutical Technology Co., LTD; Chen, Ben Shun; Zhou, Zhang Yue; Chen, Kai; Qi, Chen Chen; (14 pag.)CN104230817; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia