Tag: M.W=400-500

Adding a certain compound to certain chemical reactions, such as: 799842-07-2, N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C16H19BrFN3O2S, blongs to pyrimidines compound. Formula: C16H19BrFN3O2S

39.68 grams of 5-methoxy-2-mercapto benzimidazole compound of formula-19b is added to aqueous sodium hydroxide solution(9.61 gm sodium hydroxide in 200 ml water) at 25 to 350C and stirred for 15 minutes, then added a solution of 400 ml of acetone and 100 grams of [4-(4-Fluoro phenyl) – 6 -isopropyl -2-(N-Methyl-N-methane Sulphonyl amino pyrimidine-5yl] methyl bromide compound of formula- 18a and stirred for 2 hours at 25 to 3O0C. Quenched the reaction mass with chilled water filtered the obtained precipitate and dried the compound at 60-650C for 3 hours to get the title compound. Yield: 110 grams. M.R: 159-163C.

The synthetic route of 799842-07-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; SAHADEVA REDDY, Maramreddy; WO2007/125547; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 799842-07-2 , The common heterocyclic compound, 799842-07-2, name is N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide, molecular formula is C16H19BrFN3O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example-3Preparation of N-[4-(4-FIuoro-phenyl)-6-isopropyI-5-(pyridin-2-ylsulfanylmethyl)- pyrimidin-2-yI]-N-methyl-methanesulfonamide (III)2-mercaptopyridine (II) 3.23g was taken in 16mL tetrahydrofuran and chilled to -25 to -30 C and added 30% n-butyl lithium(l 1.OmL) drop wise at -5 to -10 C and stirred at the same temperature for one hour. Added N-[5-Bromomethyl-4-(4-fluoro-phenyl)-6- isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide (11. Og) dissolved in 22 mL THF at -60 C to -700C drop wise and stirred for 15 minutes at -60 to-70 C. Slowly brought the temperature to 250C and stirred for 2 h. Adjusted the pH of the reaction mixture to 7-8 with saturated ammonium chloride and added 5OmL ethyl acetate and separated the layers. Organic layer was given water washes and a brine wash. Organic layer was dried over anhydrous sodium sulphate and concentrated to get solid N-[4-(4- Fluoro-phenyl)-6-isopropyl-5-(pyridin-2-ylsulfanylmethyl)-pyrimidin-2-yl]-N-methyl- methanesulfonamide (V) Yield: 11. Og

The synthetic route of 799842-07-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOCON LIMITED; ANEGONDI, Sreenivasa, Prasad; RAJMAHENDRA, Shanmughasamy; JOSEPH, Jibin; SRINIVAS, Pullela, Venkata; WO2010/23678; (2010); A1;,
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Related Products of 1152107-25-9, Adding some certain compound to certain chemical reactions, such as: 1152107-25-9, name is Gsk-1322322,molecular formula is C22H34FN7O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1152107-25-9.

Example 10 Synthesis of N-(( ?)-2-(cyclopentylmethyl)-3-(2-(5-fluoro-6-((S)- hexahydro pyrazino[2,1 -c][1,4]oxazin-8(1 H)-yl)-2-methylpyrimidin-4- yl)hydrazinyl)-3-oxopropyl)-N-hydroxyformamide methanesulfonateN-(( ?)-2-(cyclopentylmethyl)-3-(2-(5-fluoro-6-((S)-hexahydropyrazino[2,1- c][1,4]oxazin-8(1 H)-yl)-2-methylpyrimidin-4-yl)hydrazinyl)-3-oxopropyl)-N- hydroxyformamide methanesulfonateTo a 1-L Labmax was added N-(( )-2-(cyclopentylmethyl)-3-(2-(5-fluoro-6-((S)- hexahydropyrazino[2, 1-c][1 ,4]oxazin-8(1 H)-yl)-2-methylpyrimidin-4-yl)hydrazinyl)-3- oxopropyl)-N-hydroxyformamide (100 g, 209 mmol) and n-Propanol (600 mL). The contents were heated to 60C and methanesulfonic acid (13.54 mL, 209 mmol) was added via pipette. Solution was transferred through filter paper and into a clean 1-L Labmax. A rinse of n-propanol (100 mL) was transferred through the filter and into the clean 1-L Labmax. The resulting solution was adjusted to 50C. The solution was seeded with N-((f?)-2-(cyclopentylmethyl)-3-(2-(5-fluoro-6-((S)-hexahydropyrazino[2, 1- c][1 ,4]oxazin-8(1 H)-yl)-2-methylpyrimidin-4-yl)hydrazinyl)-3-oxopropyl)-N- hydroxyformamide methanesulfonate Form 1 (1.0 g, 1.7 mmol). The resulting slurry was aged for 1 hour at 50C. The slurry was cooled to 20C at a linear rate of0.1 C/min. The slurry was aged for 2 hours at 20C. The slurry was cooled to 0C at a linear rate of 0.1 C/min and aged overnight. The slurry was filtered under nitrogen and the cake was washed with chilled n-propanol (100 mL). The resulting wet cake was blown with nitrogen. The wet cake was then dried under vacuum at 50C. After drying, 104 g (86.7% yield) of N-(( )-2-(cyclopentylmethyl)-3-(2-(5-fluoro-6-((S)- hexahydropyrazino[2, 1-c][1 ,4]oxazin-8(1 H)-yl)-2-methylpyrimidin-4-yl)hydrazinyl)-3- oxopropyl)-N-hydroxyformamide methanesulfonate was obtained. H NMR (500 MHz, DMSO-d6, referenced to TMS = 0.00 ppm, T = 25 C, rotamers present due to hindered rotation, major rotamers listed with integration rounded to nearest 1/2 units) delta ppm 10.5-9.7 (3H, several broad s), 9.05 (1/2 H, s), 9.02 (1/2 H, s), 8.31 (1/2 H, s), 7.87 (1/2 H, s), 4.38 (1 H, d, J = 13 Hz), 4.30 (1 H, d, J = 14 Hz), 4.08-4.00 (2H, several m), 3.80-3.72 (3/2 H, several m), 3.56-3.24 (17/2 H, several m), 3.02-2.98 (1 H, m), 2.82-2.69 (1 H, several m), 2.38 (3H, s), 2.26-2.23 (3H, several s), 1.99-1.90 (2H, several m), 1.71 (1 H, broad m), 1.66-1.47, (5H, several m), 1.27- 1.20 (1 H, m), 1.08-1.02 (2H, several m).3C NMR (126 MHz, DMSO-d6, referenced to DMSO-d6 = 39.51 ppm, T = 25 C, rotamers present due to hindered rotation, major rotamers listed with integration rounded to nearest 1/2 units) delta ppm 172.8 (rotamer 1/2 C), 172.7 (rotamer 1/2 C), 162.0 (rotamer 1/2 C), 160.1 (d, J13C-I9F = 9 Hz) (rotamer 1/2 C), 160.0 (d, J13C-I9F = 9 Hz) (rotamer 1/2 C), 157.4 (rotamer 1/2 C), 152.5 (d, J13C-I9F = 10 Hz), 148.2 (broad), 130.4 (d, J13C-19F = 249 Hz) (rotamer 1/2 C), 130.3 (d, J13C-I9F = 249 Hz) (rotamer 1/2 C), 65.2, 63.7, 60.1 , 52.0 (rotamer 1/2 C), 51.7, 51.4, 48.9 (rotamer 1/2 C), 43.8 (broad), 43.4 (broad), 41.2 (rotamer 1/2 C), 41.1 (rotamer 1/2 C), 39.8, 37.0 (rotamer 1/2 C), 36.9 (rotamer 1/2 C), 35.6 (rotamer 1/2 C), 35.5 (rotamer 1/2 C), 32.9, 31.6, 24.9, 24.7 (2C).HRMS (ESI): calcd for C22H35FN704[M + H]+ 480.2730, found 480.2731.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1152107-25-9, Gsk-1322322, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY NO 2 LIMITED; BULLOCK, Kae Miyake; DESCHAMPS, Nicole; ELITZIN, Vassil; FITZGERALD, Russell; GRADDY, William Hawthorne; MATSUOKA, Richard Tadao; MCKEOWN, Robert Rahn; MITCHELL, Mark Bryan; SHARP, Matthew Jude; SUTTON, Peter W.; TABET, Elie Amine; ZHOU, Xiaoming; WO2014/141181; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 799842-07-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 799842-07-2, name is N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide. A new synthetic method of this compound is introduced below.

Example 3: Preparation of N-[4-(4-fluoro-phcnyl)-6-isopropyl-5-(4-mcthyl-4i1-[1,2,41 triazol-3-ylsulfanylmethyl)pyrimidin-2-yll -N-methyl-methane-sulfonamide Method A: To a solution of 4-methyl-4H-{l,2,4triazole-3-thiol (7.62g) in ethyl acetate (250ml), potassium carbonate (20g) was added and the reaction rnixtur was stirred for 30minutes at 25 to 30C. N-[5-Bromomethyl-4-(4-fluorophnyl)-6?-isopropylpyrimidin-2-yl]-N-methyl-methane sulfonamide (25g) was added and temperature was raised to 30 to 35C and stirred for 4 hours; After completion of reaction, the reaction mass was quenched with water (200m1). The organic-layer was separated and aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with brine, dried on anhydrous sodium sulphate andconcentrated. Isopropyl ether (SUm) was added to the residue and stirred for 30 minutes at 25-30C and the resulting solid was filtered, washed with diisopropyl ether and dried to give (27g)of title compound which is characterizedby ?H-NMR and mass spectra.1H-NMR, (400 MHz, CDCI3, ppm): 1.34 (d, 6H), 3.50 (s, 4H), 3.53 (s, 6H), 4.50 (s, 2H), 7.12(dd, 2H), 7.65 (dd, 2H), 8.19 (s, 1H);Mass (M+1)45l amu

At the same time, in my other blogs, there are other synthetic methods of this type of compound,799842-07-2, N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide, and friends who are interested can also refer to it.

Reference:
Patent; IND-SWIFT LABORATORIES LIMITED; NAIK RAJESH VINODRAI; JAIN ANSHUL KUMAR; SARIN GURDEEP SINGH; SAINI VINAY KUMAR; KUMAR VIJAY; WO2015/37018; (2015); A1;,
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Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 147118-40-9, name is Rosuvastatin methyl ester. A new synthetic method of this compound is introduced below., 147118-40-9

Example 4130.0 g (0.061 mol) of crystalline Form II rosuvastatin methylester are suspended in 150 cm3 of water with stirring at 25 ¡ãC. Into the suspension thus obtained, 61 cm of 1.0 M aqueous TBA solution are added. Thereafter in two hours periods, each time 12.2 cm3 of 1.0 M aqueous TBA solution added to the reaction mixture four times. After 16 hours reaction time, a further 12.2 cm3 portion of 1.0 M aqueous TBA solution are added and the reaction mixture is stirred for a further 24 hours. The product is filtered, washed with cold ethylacetate and dried. Thus 28.5 g (84 percent) of white product having purity (HPLC) of 99.98 percent are obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,147118-40-9, Rosuvastatin methyl ester, and friends who are interested can also refer to it.

Reference:
Patent; EGIS GYOGYSZERGYAR NYILVANOSAN M?KOeD? RESZVENYTARSASAG; KOVANYINE LAX, Gyoergyi; SIMIG, Gyula; VOLK, Balazs; BARTHA, Ferenc Lorant; KRASZNAI, Gyoergy; RUZSICS, Gyoergy; SIPOS, Eva; NAGY, Kalman; MOROVJAN, Gyoergy; BARKOCZY, Jozsef; KESZTHELYI, Adrienn; IMRE, Janos; BAGYINSZKI, Gabor; WO2012/73055; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 147118-40-9, name is Rosuvastatin methyl ester. A new synthetic method of this compound is introduced below., 147118-40-9

7- [4-(4-Fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-n ethyl-amino)- pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid methyl ester (500 g) was treated with aqueous sodium hydroxide ( 60 g sodium hydroxide in 2.5 L water ) and stirred the reaction mass at 25-35 ¡ãC for 1-2 hours. After completion of reaction, reaction mass was cooled to ambient temperature and activated carbon (25 g) was added and stirred for 30 minutes. Reaction mixture was filtered through hyflow bed and wash bed with water. Resulting filtrate was washed with methyl tert-butyl ether (4 x 1.5 L). Ethyl acetate (2.5 L) was added to resulting mixture followed by addition of concentrated hydrochloric acid to adjust pH of reaction mixture 1 to 2 at 10-15 ¡ãC and stirred. Layers were separated and aqueous layer was re-extracted with ethyl acetate (1 L). Combined organic layer was washed with brine solution. (+)-l-(l-naphthyl)ethylamine (175 g) diluted with ethyl acetate (250 ml) was added to the resulting organic layer to adjust the pH of reaction mixture to 7- 8. Solvent was distilled off completely from the reaction mixture. Ethyl acetate (2.5 L) was added to resulting residue followed by addition of (+)-l-(l-naphthyl)ethylamine (170 g) diluted with ethyl acetate (250 ml) and stirred for 6-8 hours at ambient temperature. n-Heptane (1.5 L ml) was added to resulting mixture and cooled the mixture at -5 ¡ãC. Resulting reaction mixture was stirred for 1 hour, filtered, washed with n-heptane. Resulting wet product was slurried in acetonitrile (2.5 L), filtered, washed with acetonitrile (250 ml) and dried to give 310 g of title compound having purity 99.74 percent; anti-isomer: 0.2 percent; lactone: not detected; 5-keto acid impurity: not detected by HPLC.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,147118-40-9, Rosuvastatin methyl ester, and friends who are interested can also refer to it.

Reference:
Patent; IND-SWIFT LABORATORIES LIMITED; BHIRUD Shekhar Bhaskar; JAIN Anshul Kumar; SAINI Vinay Kumar; SHARMA Alok; WO2012/176218; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

147118-40-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 147118-40-9, name is Rosuvastatin methyl ester, molecular formula is C23H30FN3O6S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of methyl (6E)-7-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methyl sulfonyl)amino]pyrimidin-5-yl}(3R,5S)-3,5-dihydroxyhept-6-enoate (2g, 4.04mmol) in 30ml of acetonitrile, 0.25N solution of NaOH (17.7ml; 4.44mmol) was added over a period of 5 minutes at temperature between 26~29¡ãC with stirring. After stirring for 3-4 hours, 30ml tert-butyl methyl ether was added followed by 10ml of water. The layers were separated and organic layer was extracted with 20ml of water. The combined aqueous layers were concentrated by evaporation under reduced pressure to its half volume. To the concentrated aqueous layer, a 1 M solution of CaCl2.2H2O (2.02ml, 2.02mmol) was added drop wise with stirring at 25-28¡ãC. After stirred for 45 minutes, the precipitate formed was filtered and washed with water to get Rosuvastatin Calcium as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 147118-40-9, Rosuvastatin methyl ester, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNICHEM LABORATORIES LIMITED; WO2006/106526; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

147118-40-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 147118-40-9, name is Rosuvastatin methyl ester. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 16 (149 mg, 0.3 mmol) in MeOH (2 mL) at 0 ¡ãC was added NaOH (0.36 mL, 1.0 M, 0.36 mmol), then reacted at 0 ¡ãC for 1 h before being added the solution of CaCl2 (1.5 mL, 0.2 M, 0.3 mmol). The mixture was stirred at 20 ¡ãC for 0.5 h before filtrated the resulting white slurry, washed, and dried in vacuum to afford 1 (133 mg, 89percent) as a white powder; mp 145-149 ¡ãC, lit. 17 mp 145-150 ¡ãC; [a]D14.5 7.3 (c 0.5, CHCl3); 1H NMR (400 MHz, CDCl3) d 1.20 (d, J=6.0 Hz, 6H), 1.28-1.36 (m, 1H), 1.47-1.54 (m, 1H), 1.97-2.03 (m, 1H), 2.12-2.16 (m, 1H), 3.36-3.43 (m, 1H), 3.43 (s,3H), 3.54 (s, 3H), 3.76 (m, 1H), 4.20 (m, 1H), 5.52 (dd, J=5.6, 16.0 Hz, 1H), 6.50 (d, J=16.0 Hz, 1H), 7.27 (t, J=8.4 Hz, 2H), 7.70 (dd, J=6.0,8.0 Hz, 2H); MS (ESI): m/z 482 (acid, MH), 504 (acid, MNa); IR (KBr): 3376, 2973, 2931, 2875, 1604, 1548, 1442, 1073, 968, 844, 776 cm-1.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 147118-40-9, Rosuvastatin methyl ester.

Reference:
Article; Chen, Xiaofei; Xiong, Fangjun; Zheng, Chen; Li, Jie; Chen, Fener; Tetrahedron; vol. 70; 35; (2014); p. 5794 – 5799;,
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147118-40-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 147118-40-9 as follows.

Chromatographic column:LiChrospher 100 DIOL 10 mum 250 x 20mm Mobile phase A:diisopropyl ether (DIPE) Mobile phase B:1,5percent isopropanol, 98,5percent DIPE Flow rate:60 ml/min Detection:UV, 345 nm Injection volume:60 ml 1,5 g of the crude sample (assay 70percent) is dissolved in 60 ml of diisopropylether. The obtained solution is loaded on a chromatographic column, previously conditioned with mobile phase A. After the sample load the chromatographic column is eluted with mobile phase B. A central portion (ca 100 ml) of main peak is collected. The obtained fraction is pure MER, with ca 99,8 percent chromatographic purity, and ca 6-7percent of enantiomer, as shown on Fig.3

The chemical industry reduces the impact on the environment during synthesis 147118-40-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; LEK Pharmaceuticals d.d.; EP2022784; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 125401-75-4, name is 2,6-Bis((4,6-dimethoxypyrimidin-2-yl)oxy)benzoic acid. This compound has unique chemical properties. The synthetic route is as follows. 125401-75-4

EXAMPLE 1 Preparation of 1-ethoxycarbonyloxyethyl 2,6-bis[(4,6-dimethoxypyrimidin -2-yl)oxy]benzoate (Compound No. 5) 1.7 g (4.0 mmol) of 2,6-bis[(4,6-dimethoxypyrimidin-2-yl) oxy]benzoic acid and 0.2 g of 60% sodium hydride were dissolved in N,N-dimethylformamide. After the generation of hydrogen ceased, 0.68 g (4.4 mmol) of 1-chloroethylethylcarbonate was added to the solution and the resultant mixture was reacted at 100 C. for 1 hour. After completing the reaction, the reaction mixture was added to ice water and was extracted with ethyl acetate. The ethyl acetate layer was dried with anhydrous sodium sulfate, and the ethyl acetate was distilled off. The residue was purified by silica gel column chromatography, and ethanol/hexane were added thereto to precipitate a solid, which was then filtered out to obtain 1.4 g of a white crystal having a melting point of from 97 to 100 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 125401-75-4, 2,6-Bis((4,6-dimethoxypyrimidin-2-yl)oxy)benzoic acid.

Reference:
Patent; Kumiai Chemical Industry Co. Ltd.; Ihara Chemical Industry Co., Ltd.; US5154750; (1992); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia