Tag: M.W=50-100

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Synthetic Route of 109-12-6.

Zhang, Zi-Peng;Liu, Xin;Liu, Xiaomeng;Lu, Zhong-Wei;Sui, Xin;Zhen, Bo-Yu;Lin, Zheshuai;Chen, Ling;Wu, Li-Ming research published 《 Driving Nonlinear Optical Activity with Dipolar 2-Aminopyrimidinium Cations in (C₄H₆N₃)⁺(H₂PO₃)^–》, the research content is summarized as follows. Organic-inorganic hybrid nonlinear optical (NLO) crystals have been attracting increasing attention because of their unique ability to combine the structural diversity of the organic moiety and the high stability of the inorganic moiety. However, organic NLO genes are rare. Herein, a new organic NLO material gene, the 2-aminopyrimidinium cation (C₄H₆N₃)⁺ ((2AP)⁺), is reported, which constructs a novel organic-inorganic hybrid (C₄H₆N₃)⁺(H₂PO₃)^– (2APP) that exhibits excellent NLO properties and thermal stability, e.g., strong second-harmonic generation (SHG) intensity (2 x KDP), large birefringence (0.225 at 589.3 nm), high laser-induced-damage threshold (1.7 x KDP), and one of the highest thermal stabilities among the metal-free-(2AP)⁺-containing compounds Our first-principles theor. studies confirm the dominant contribution of (2AP)⁺ to optical properties. The inorganic phosphite anions well sep. the (2AP)⁺ cations to successfully eliminate the unwanted centrosym. trap that is induced by the dipole-dipole interactions between (2AP)⁺ cations. Furthermore, the unique layered structure decorated by the uniformly oriented individual (2AP)⁺ chromophores, dramatically enhances the quantum yield of purple fluorescence (Φ = 30.6%), which is 3 orders of magnitude higher than that of pure 2AP and its derivatives

Synthetic Route of 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Safety of Pyrimidin-2-amine.

Zheng, Qiang;Li, Xin;Kurpiewska, Katarzyna;Doemling, Alexander research published 《 Synthesis of Tunable Fluorescent Imidazole-Fused Heterocycle Dimers》, the research content is summarized as follows. A short, concise, and one-pot synthesis of imidazo-fused heterocycle dimers with tunable fluorescent properties has been developed. By the first time use of glyoxal di-Me acetal in the Groebke-Blackburn-Bienayme (GBB) three-component reaction (3CR), the innovation features a new series of fluorescence-tunable imidazo-fused heterocycle dimers exhibiting a broad substrate scope with good yields. Luminescence studies demonstrate that these GBB-dimers possess color-tunable properties, and their emission colors can be successively changed from blue to green and yellow by easy substituent control.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Safety of Pyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Computed Properties of 109-12-6.

Zheng, You-Guang;Wang, Jin-An;Meng, Long;Pei, Xin;Zhang, Ling;An, Lin;Li, Cheng-Lin;Miao, Ying-Long research published 《 Design, synthesis, biological activity evaluation of 3-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole derivatives as potent JAK 2/3 and aurora A/B kinases multi-targeted inhibitors》, the research content is summarized as follows. A series of 3-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole I[R¹ = 1-pyrrolidinyl, 1-piperidyl, morpholino; R² = benzoyl, 4-methoxybenzoyl, 4-nitrobenzoyl, etc.] were designed, synthesized, and evaluated for their biol. activities was studied. Upon performing kinase assays, most of the compounds exhibited potent inhibition against JAK2/3 and Aurora A/B with the IC₅₀ values ranging from 0.008 to 2.52μM. Among these derivatives, compound I [R¹ = morpholino; R² =3-chlorobenzoyl] expressed the most moderate inhibiting activities against all the four kinases with the IC₅₀ values of 0.166μM (JAK2), 0.057μM (JAK3), 0.939μM (Aurora A), and 0.583μM (Aurora B), resp. Moreover, most of the derived compounds exhibited potent cytotoxicity against human chronic myeloid leukemia cells K562 and human colon cancer cells HCT116, while compound I[R¹ = morpholino; R² =3-chlorobenzoyl] expressed antiproliferative activities against K562 (IC₅₀=6.726μM). According to western blot anal., compound I[R¹ = morpholino; R² =3-chlorobenzoyl] down-regulated the phosphorylation of STAT3, STAT5, Aurora A, and Aurora B in a dose-dependent manner in K562 and HCT116 cells. Cell cycle anal. revealed that compound I[R¹ = morpholino; R² =3-chlorobenzoyl] inhibited the proliferation of cells by inducing cell cycle arrest in the G2 phase. The mol. modeling suggested that compound I[R¹ = morpholino; R² =3-chlorobenzoyl] maintained a binding mode similar to the binding mode of AT9832, a common JAK 2/3 and Aurora A/B kinases multi-target kinase inhibitor. Therefore, compound I[R¹ = morpholino; R² =3-chlorobenzoyl] was a potential agent for cancer therapy deserving further research.

Computed Properties of 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Application of C4H5N3.

Zhou, Jie;Wang, Donglin;Ju, Feng;Hu, Wanchao;Liang, Jinsong;Bai, Yaohui;Liu, Huijuan;Qu, Jiuhui research published 《 Profiling microbial removal of micropollutants in sand filters: Biotransformation pathways and associated bacteria》, the research content is summarized as follows. Although there is growing evidence that micropollutants can be microbially converted in rapid sand filters of drinking water treatment plants (DWTPs), little is known about the biotransformation pathways and associated microbial strains in this process. Here, we constructed sand filter columns filled with manganese or quartz sand obtained from full-scale DWTPs to explore the biotransformation of eight micropollutants. Under seven different empty bed contact times (EBCTs), the column experiments showed that caffeine and atenolol were easily removed (up to 92.1% and 97.6%, resp.) with adsorption and microbial biotransformation of the filters. In contrast, the removal of other six micropollutants (i.e., naproxen, carbamazepine, atrazine, trimethoprim, sulfamethoxazole, and sulfadiazine) in the filters were less than 27.1% at shorter EBCTs, but significantly increased at EBCT = 4 h, indicating the dominant role of microbial biotransformation in these micropollutants removal. Integrated anal. of metagenomic reads and transformation products of micropollutants showed a shift in caffeine oxidation and demethylation pathways at different EBCTs, simultaneous occurrence of atrazine hydrolysis and oxidation pathways, and sulfadiazine and sulfamethoxazole oxidation in the filters. Furthermore, using genome-centric anal., we observed previously unidentified degrading strains, e.g., Piscinibacter, Hydrogenophaga, and Rubrivivax for caffeine transformation, and Methylophilus and Methyloversatilis for atenolol transformation.

Application of C4H5N3, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Synthetic Route of 109-12-6.

Zhang, Fuli;Lai, Qingfu;Lai, Weihong;Li, Ming;Jin, Xiaobao;Ye, Lianbao research published 《 Phloroglucinol derivatives as anti-tumor agents: synthesis, biological activity evaluation and molecular docking studies》, the research content is summarized as follows. Phloroglucinol compounds isolated from Dryopteris fragrans (L.) Schott showed a variety of biol. activities, such as anticancer and anti-inflammatory. In this study, we have made a number of modifications around the scaffold of phloroglucinol and synthesized phloroglucinol derivatives A1-A9, B1-B9, and C1-C3. We synthesized these compounds and investigated their effect on four human cancer cell lines (A-549, MCF-7, Hela, HepG2 cell lines) via MTT assay in vitro. The results revealed that all compounds exhibited certain antiproliferative activities on cancer cell lines and excellent inhibitory effects on MCF-7, in which compound C2 was the best with the IC₅₀ value of 18.49 μM, exceeding that of 5-fluorouracil. Moreover, the cell apoptosis test showed that compound C2 induced apoptosis in a concentration-dependent manner. Furthermore, the results of mol. docking anal. explained the probable interaction between the active compounds and active sites of target protein 4I22 and 1OG5.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Synthetic Route of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Synthetic Route of 109-12-6.

Zhang, Rui;Yao, Wei-Zhong;Qian, Liang;Sang, Wei;Yuan, Ye;Du, Min-Chen;Cheng, Hua;Chen, Cheng;Qin, Xin research published 《 A practical and sustainable protocol for direct amidation of unactivated esters under transition-metal-free and solvent-free conditions》, the research content is summarized as follows. In this paper, a NaOtBu-mediated synthesis approach was developed for direct amidation of unactivated esters RC(O)OR¹ (R = Ph, pyridin-2-yl, cyclopropyl, Me, pyrazin-2-yl, etc.; R¹ = Me, Et, Ph, etc.) with amines R²R³NH (R² = Ph, n-hexyl, benzyl, etc.; R³ = H, Me; R²R³ = -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-) under transition-metal-free and solvent-free conditions, affording a series of amides R(CO)NR²R³ in good to excellent yields at room temperature In particular, an environmentally friendly and practical workup procedure, which circumvents the use of organic solvents and chromatog. in most cases, was disclosed. Moreover, the gram-scale production of representative products R(CO)NR²R³ (R = Ph, R² = Ph, 2-phenylethyl, R³ = H; R = Me, R² = Ph, R³ = H) was efficiently realized by applying operationally simple, sustainable and practical procedures. Furthermore, this approach was also applicable to the synthesis of valuable mols. such as moclobemide (a powerful antidepressant), benodanil and fenfuram (two com. agricultural fungicides). These results demonstrate that this protocol has the potential to streamline amide synthesis in industry. Meanwhile, quant. green metrics of all the target products were evaluated, implying that the present protocol is advantageous over the reported ones in terms of environmental friendliness and sustainability. Finally, addnl. experiments and computational calculations were carried out to elucidate the mechanistic insight of this transformation, and one plausible mechanism was provided on the basis of these results and the related literature reports.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Synthetic Route of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Related Products of 109-12-6.

Zhang, Shun;Zhao, Yan;Wang, Shuyuan;Li, Min;Xu, Yue;Ran, Jianhua;Geng, Xiaoqiang;He, Jinzhao;Meng, Jia;Shao, Guangying;Zhou, Hong;Ge, Zemei;Chen, Guangping;Li, Runtao;Yang, Baoxue research published 《 Discovery of novel diarylamides as orally active diuretics targeting urea transporters》, the research content is summarized as follows. Urea transporters (UT) play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors are promising for development as novel diuretics. In the present study, a novel UT inhibitor with a diarylamide scaffold was discovered by high-throughput screening. Optimization of the inhibitor led to the identification of a promising preclin. candidate, N-[4-(acetylamino)phenyl]-5-nitrofuran-2-carboxamide (1H), with excellent in vitro UT inhibitory activity at the submicromolar level. The half maximal inhibitory concentrations of 1H against UT-B in mouse, rat, and human erythrocyte were 1.60, 0.64, and 0.13 μmol/L, resp. Further investigation suggested that 8 μmol/L 1H more powerfully inhibited UT-A1 at a rate of 86.8% than UT-B at a rate of 73.9% in MDCK cell models. Most interestingly, we found for the first time that oral administration of 1H at a dose of 100 mg/kg showed superior diuretic effect in vivo without causing electrolyte imbalance in rats. Addnl., 1H did not exhibit apparent toxicity in vivo and in vitro, and possessed favorable pharmacokinetic characteristics. 1H shows promise as a novel diuretic to treat hyponatremia accompanied with volume expansion and may cause few side effects.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Related Products of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. SDS of cas: 109-12-6.

Zhang, Tao;Qu, Rong;Chan, Shingpan;Lai, Mengzhen;Tong, Linjiang;Feng, Fang;Chen, Hongyu;Song, Tingting;Song, Peiran;Bai, Gang;Liu, Yingqiang;Wang, Yanan;Li, Yan;Su, Yi;Shen, Yanyan;Sun, Yiming;Chen, Yi;Geng, Meiyu;Ding, Ke;Ding, Jian;Xie, Hua research published 《 Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance》, the research content is summarized as follows. Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations initially respond to first-generation EGFR inhibitors; however, the efficacy of these drugs is limited by acquired resistance driven by the EGFR ^T790M mutation. The discovery of third-generation EGFR inhibitors overcoming EGFR ^T790M and their new resistance mechanisms have attracted much attention. We examined the antitumor activities and potential resistance mechanism of a novel EGFR third-generation inhibitor in vitro and in vivo using ELISA, SRB assay, immunoblotting, flow cytometric anal., kinase array, qRT-PCR and tumor xenograft models. The clin. effect on a patient was evaluated by computed tomog. scan. We identified compound ASK120067 as a novel inhibitor of EGFR ^T790M, with selectivity over EGFR ^WT. ASK120067 exhibited potent anti-proliferation activity in tumor cells harboring EGFR ^T790M (NCI-H1975) and sensitizing mutations (PC-9 and HCC827) while showed moderate or weak inhibition in cells expressing EGFR ^WT. Oral administration of ASK120067 induced tumor regression in NSCLC xenograft models and in a PDX model harboring EGFR ^T790M. The treatment of one patient with advanced EGFR T790M-pos. NSCLC was described as proof of principle. Moreover, we found that hyperphosphorylation of Ack1 and the subsequent activation of antiapoptotic signaling via the AKT pathway contributed to ASK120067 resistance. Concomitant targeting of EGFR and Ack1 effectively overrode the acquired resistance of ASK120067 both in vitro and in vivo. Our results identify ASK120067 as a promising third-generation EGFR inhibitor and reveal for the first time that Ack1 activation as a novel resistance mechanism to EGFR inhibitors that guide to potential combination strategy.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., SDS of cas: 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Product Details of C4H5N3.

Zhang, Yi;Chen, Rener;Wang, Zhiming;Wang, Lei;Ma, Yongmin research published 《 I₂-Catalyzed Three-Component Consecutive Reaction for the Synthesis of 3-Aroylimidazo[1,2-a]-N-Heterocycles》, the research content is summarized as follows. A convenient one-pot, three-component reaction has been developed for the synthesis of 3-aroylimidazo[1,2-a]-N-heterocycles from aryl ketones and 2-amino-N-heterocycles using DMSO as a methylene donor. The reaction proceeds smoothly catalyzed by I₂ in the presence of K₂S₂O₈ and affords the desired products in moderate to good yields. This protocol offers significant superiority in accessing biol. active 3-aroylimidazo[1,2-a]-N-heterocycles with various substitution patterns.

Product Details of C4H5N3, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Reference of 109-12-6.

Xu, Qun;Li, Tian;Chen, Hekai;Kong, Jun;Zhang, Liwei;Yin, Hang research published 《 Design and optimisation of a small-molecule TLR2/4 antagonist for anti-tumour therapy》, the research content is summarized as follows. A small-mol. co-inhibitor that targets the TLR2/4 signalling pathway were developed. After high-throughput screening of a compound library containing 14400 small mols., followed by hit-to-lead structural optimization, the compound I was finally obtained, which has effective inhibitory properties against the TLR2/4 signalling pathways. This compound was found to significantly inhibit multiple pro-inflammatory cytokines released by RAW264.7 cells. This was followed by compound I demonstrating promising efficacy in subsequent anti-tumor experiments The current results provided a novel understanding of the role of TLR2/4 in cancer and a novel strategy for anti-tumor therapy.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Reference of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia