Tag: M.W=500-600

Application of 274693-26-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.274693-26-4, name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol, molecular formula is C26H32F2N6O4S, molecular weight is 562.63, as common compound, the synthetic route is as follows.

Charge (2.6 gm) of compound 28 in (8-10 Vol.) of Methanol at Room temperature. Charge dilute HC1 (1.4 gm) at RT. Stir the reaction mass for 24 hours at RT. Upon completion of the reaction checked by TLC, the reaction mass was brought to slightly acidic pH of 6-6.5 by using dilute aq. NaOH. Upon removal of methanol under vacuum and extracting organic mass with ethyl acetate and further washing this organic layer with brine and concentration of ethyl acetate under vacuum gave crude Ticagrelor 1. Further purification of Ticagrelor 1. was carried out by crystallization from a mixture of ethyl acetate and heptane to provide white to off-white solid. The purity of Ticagrelor 1 was 99.6% (HPLC). Some of the characteristic and selective peaks (delta value) in -NMR (CDG13) for 1 are 7.5 (s, 1H), 6.83 – 7.2 (m, 3H), 5.67 (m, 1 H), 5.04 (m, 1H), 4.82 (m, 1H), 4.13 (m, 1H), 3.6 – 3.9 (m, 4H), 3.2 (t, 2H), 1.57 (m, 2H), 0.79 (t, 3H).

Statistics shows that 274693-26-4 is playing an increasingly important role. we look forward to future research findings about 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol.

Reference:
Patent; ANLON CHEMICAL RESEARCH ORGANIZATION; RASADIA, Punitkumar Rameshbhai; RAMANI.Vaibhav Narendrakumar; PANDEY, Bipin; BHADANI, Vijay Nagjibhai; VACHHANI, Dipakkumar Dhanjibhai; SHAH, Anamik Kantilal; WO2015/162630; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 355806-00-7, (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl) methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C26H36FN3O6S, blongs to pyrimidines compound. Computed Properties of C26H36FN3O6S

(2) Preparation of sodium (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl) amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxy-hept-6-enoate (compound IV) To a 5 L four-necked flask, 2 L (10 mL/g) of acetonitrile and 200 g (1 mol) of tert-butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methanesulfonyl)amino]-5-pyrimidinyl]vinyl]-2,2-dimethyl-1,3-dioxane-4-acetate (compound III) were added, and stirred to homogeneity, followed by adding 14.8 g (0.02 mol, calculated from titrated content) of an aqueous solution of hydrochloric acid having a mass percentage concentration of 0.06%. The system was warmed up to 35 C. and stirred at the same temperature for 5 hours until compound III was completely consumed. To the reaction system was added dropwise 32.5 g (1.1 mol) of an aqueous solution of sodium hydroxide having a mass percentage concentration of 4%, and stirred at 20 C. for 7 hours until the dihydroxy ester intermediate produced in the first phase was completely consumed. The system was concentrated to remove acetonitrile, followed by adding 2 L (10 mL/g) of purified water, and stirred to clearness. The system was extracted three times with 400 mL (2 mL/g) of methyl tert-butyl ether. The aqueous phase was further concentrated until no organic solvent was left, to give the an aqueous solution of the product, sodium (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxy-hept-6-enoate (compound IV), with a purity of >98% and a yield of 97%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,355806-00-7, (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl) methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester, and friends who are interested can also refer to it.

Reference:
Patent; Asymchem Laboratories (Tianjin) Co., Ltd.; Asymchem Life Science (Tianjin) Co., Ltd.; Tianjin Asymchem Pharmaceutical Co., Ltd.; Asymchem Laboratories (Fuxin) Co., Ltd.; Jilin Asymchem Laboratories Co., Ltd.; HONG, Hao; GAGE, James; LI, Jiuyuan; SHEN, Litao; ZHANG, Lei; DONG, Changming; (12 pag.)US2017/22169; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 274693-26-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 274693-26-4, name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol. A new synthetic method of this compound is introduced below.

Under nitrogen, the reaction flask were added isopropylidene ticagrelor, N,N- diisopropylethylamine (2.30g, 17.8mmol) and tetrahydrofuran 10mL, stirring (1.00g, 1.78mmol) 5 C to clarification, cooled to -5 C ~ 0 C. 5ml of tetrahydrofuran was added dropwise to the reaction solution phosphorus oxychloride (2.72g, 17.7mmol), the reaction solution is controlled temperature 0 C~ 5 C, 10min dropwise addition, the reaction temperature 0 C ~ 5 C for 2h. Under nitrogen, the reaction solution was slowly added dropwise 20ml of methanol, 0 C ~ 5 C reaction 1h, warmed to 10 C~ 15 C reaction was continued for 1h. To the reaction was added dropwise 30ml of water, temperature 5 C ~ 15C, addition was complete, warmed to 25 C ~ 30 C reaction 1h. 60ml of ethyl acetate twice. The combined organic phase was washed with 30ml water and 30ml saturated brine the organic phase, the resulting organic phase was dried over anhydrous sodium sulfate 1g IH, suction filtered, the filtrate was distilled off under reduced pressure, to give as a white solid 1.01g, yield 90.11%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,274693-26-4, 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Hefei Medical Engineering Pharmaceutical Co., Ltd.; Hefei Enruite Pharmaceutical Co., Ltd.; Nanjing Medical Engineering Pharmaceutical Co., Ltd.; He Guangwei; Chu Zhaoxing; He Jianxun; Xu Qinlong; Ye Wenfeng; Li Jiaming; Xu Yungen; Wei Ping; Zhu Qihua; Wang Kui; Mo Jiajia; (16 pag.)CN108623629; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 289042-12-2 , The common heterocyclic compound, 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, molecular formula is C29H40FN3O6S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 4 (3R,5S,6E)-7-[4-(4-Fluorophenyl)-2-[Methyl(Methylsulfonyl)Amino]-6-(Propan-2-Yl)Pyrimidin-5-Yl]-3,5-Dihydroxyhept-6-Enoic Acid-2-Methylpropan-2-Amine (1:1) Hydrochloric acid (2 N; 60 mL) was added to a solution of tert-butyl [(4R,65)-6-{(E)-2-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]ethenyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate (Example 3; 50 g) in acetonitrile (500 mL) at room temperature and stirred at the same temperature for 3 hours. After completion of the reaction, aqueous solution of sodium hydroxide (10%; 90 mL) was added to the reaction mixture at room temperature and the temperature of the mixture was allowed to rise to 40 C. to 45 C. The pH of the reaction mixture was adjusted to 12 to 12.8 using aqueous solution of sodium hydroxide (10%). Acetonitrile was recovered completely under vacuum at 45 C. to 50 C. De-ionized water (250 mL) was added to the resulting residue at room temperature. Methyl tert-butyl ether (200 mL) was added to the mixture and stirred for 10 minutes. Layers were separated and methyl tert-butyl ether (200 mL) was added to the aqueous layer and stirred for 10 minutes. Layers were separated and aqueous layer was cooled to 5 C. to 10 C. and adjusted to a pH of 3.5 to 4.0 using hydrochloric acid (2N). Dichloromethane was added to the resulting mixture and stirred for 10 minutes to 15 minutes. Dichloromethane was recovered completely under vacuum at 35 C. to 40 C. Acetonitrile (500 mL) was added to the resulting residue and mixture was cooled to 0 C. to 5 C. To this cooled layer, tert-butyl amine (7 g) was slowly added for 30 minutes at 0 C. to 5 C. and stirred for 2 hours at 10 C. to 15 C. The product was filtered, washed with acetonitrile (50 mL) and dried under vacuum at 45 C. for 3 hours. Dry weight: 40 g

The synthetic route of 289042-12-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; Pandya, Vishwesh Pravinchandra; Richhariya, Santosh; Divya, Prabhakar; Meeran, Hashim Nizar Poovanathil Nagoor; Tewari, Neera; US2013/150579; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 289042-12-2, Adding some certain compound to certain chemical reactions, such as: 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate,molecular formula is C29H40FN3O6S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 289042-12-2.

BEM (20.0 g) was dissolved in acetonitrile (140 ml) at 40 C., then cooled to 35 C. before gradual addition of hydrochloric acid (0.02M, 35 ml) at 35 C. The resulting solution was stirred at 35 C. until the reaction was complete then cooled to 25 C. Further acetonitrile (8 ml) was added before sodium hydroxide (1.0M, 38 ml) was added at 25 C. and the resulting mixture stirred at this temperature until the reaction was complete. Aqueous hydrochloric acid (0.1M) was added to adjust the pH of the solution to approximately pH10.5. Water was added so that the combined volume of water and hydrochloric acid (0.1M) (from the previous pH adjustment step) added was 100 ml. Toluene (125 ml) was then added and the mixture stirred at 40 C. for 30 minutes before it was allowed to settle for 1 hour at 40 C. The aqueous phase was then separated from the organic phase at 40 C. The aqueous phase was distilled under reduced pressure (53 mBar, 40 C.) until the volume was reduced to 135 ml. The resulting aqueous solution was filtered through a filter pad and the filter washed with water and combined with the aqueous reaction solution, such that the total volume of the resulting aqueous solution was 170 ml. This solution was heated to 40 C. before addition of a solution of calcium chloride di-hydrate (3.05 g) in water (29.5 ml) over 20 min, maintaining the reaction mixture at 38-41 C.The reaction mixture was stirred for a further 15 min at 40 C., then cooled to 20 C. and stirred at this temperature for a further 15 min. The resulting suspension was filtered, washed with water (3×53 ml) and dried to give (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium salt (14.7 g(at)100% strength, 85% yield).1HNMR delta: 1.21 (d+d, 6H) 1.32 (dt, 1H) 1.51 (dt, 1H) 2.00 (dd, 1H) 2.14 (dd, 1H) 3.42 (spt, 1H)* 3.45 (s, 3H) 3.54 (s, 3H) 3.77 (m, 1H) 4.21 (q, 1H) 5.53 (dd, 1H) 6.51 (dd, 1H) 7.27 (t, 2H) 7.71 (dd, 2H) *partially obscured[The 1H NMR was carried out as a 3% w/v solution in d6 DMSO (where d5 DMSO=2.51delta)].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 289042-12-2, tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Butters, Michael; Lenger, Steven Robert; Murray, Paul Michael; Snape, Evan William; US2008/207903; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 289042-12-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, molecular formula is C29H40FN3O6S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of compound IV (wherein X=0 and R2=tert-butyl; 100 gms) in acetonitrile (700 mL) at 35C to 40C was added 0.05M aqueous HCl solution (300 mL). Stirred the reaction mass at 35C to 40C until reaction completion and cooled to 0C to 5C. Added 1.0 M aqueous sodium hydroxide solution (300 mL), temperature was raised to 25 C to 35C and stirred until reaction completion. Cooled the reaction mass to 0C to 5C, pH was adjusted to 3.4 to 4.0 with 1M aqueous HCl solution (300 mL) and extracted with ethyl acetate. Washed the organic layer with 10% aqueous sodium chloride solution and concentrated under vacuum. Charged ethyl acetate (800 mL) to the obtained residue followed by cyclohexane- 1,2-diamine (29.5 gms) over a period of 15-30 min. The reaction mass was stirred at 25C to 35C for 60 mins, cooled to 0C to 5C and stirred for 2 hrs. The precipitated product was filtered and dried to obtain 80 gms of rosuvastatin cyclohexane- 1,2-diamine salt as white solid. HPLC Purity: >99% The XRPD is set forth in Figure 1.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 289042-12-2, tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate.

Reference:
Patent; LAURUS LABS PRIVATE LIMITED; BOLLU, Ravindra Babu; MANDADAPU, Venkata Pramod Kumar; INDUKURI, Venkata Sunil Kumar; GORANTLA, Seeta Rama Anjaneyulu; CHAVA, Satyanarayana; (48 pag.)WO2016/125086; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 274693-26-4, name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C26H32F2N6O4S

[00141] Methanesulfonyl chloride (0.086 mL, 1.10 mmol) was added dropwise to a solution of 2-(((3 aR,4S,6R,6aS)-6-(7-((( 1 R,2S)-2-(3 ,4-difluorophenyl)cyclopropyl)amino)-5- (propylthio)-3H- [1,2,3 ltriazolo[4,5-dlpyrimidin-3 -yl)-2,2-dimethyltetrahydro-3aH- cyclopenta[dl [1 ,3ldioxol-4-yl)oxy)ethanol (See Springthorpe, B. et. al. Bioorg.Med. Chem. Lett., 2007, 17, 6013-6018) (0.563 g, 1.0 mmol) and TEA (0.209 mL, 1.50 mmol) in DCM (5 mL) at 0C. The mixture was stirred from 0 C to about 5 C over 3 h. The reaction mixture was diluted with DCM (30 mL) and washed with water (5 mL). The mixture was dried by passing through a phase separator. Evaporation of the solvent and co-evaporation from toluene gave the title compound (1.a) (714 mg, 111% ) as a yellow thick oil, which was used as crude without further purification.[00142] ?H NMR (400 MHz, CDC13) oe 1.02 (dd, 3H), 1.3 – 1.47 (m, 5H), 1.55 (s, 3H), 1.72 (d, 2H), 2.20 (d, 1H), 2.6 – 2.71 (m, 2H), 2.97 (s, 3H), 3 – 3.19 (m, 3H), 3.57 – 3.68 (m, 1H), 3.69 – 3.79 (m, 1H), 4.02 (td, 1H), 4.13 – 4.24 (m, 2H), 4.78 (dd, 1H), 5.13 (td, 1H), 5.57 (s, 1H), 6.50 (s, 1H), 7.03 (s, 1H), 7.07 – 7.16 (m, 2H).[00143] ?9F NMR (376 MHz, CDC13) oe -141.37 (J = 21.3), -138.10 (J = 21.3).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 274693-26-4, 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol.

Reference:
Patent; MEDIMMUNE LIMITED; BUCHANAN, Andrew; NYLANDER, Sven; PENNEY, Mark; NEWTON, Philip; KEYES, Feenagh; INGHARDT, Tord; (115 pag.)WO2016/50867; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 274693-26-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.274693-26-4, name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol, molecular formula is C26H32F2N6O4S, molecular weight is 562.63, as common compound, the synthetic route is as follows.

2-({(3aR,4S,6R,6aS)-6-[7-{[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxolan-4-yl}oxy)ethanol (VII) in toluene was cooled to 15 to 20 C, Then, 465 g of concentrated hydrochloric acid cooled to 15 to 20 C and 625 g of methanol were added and the reaction mixture was stirred at about 15 to 20 C for about 1 hour. The aqueous solution containing the product was added to 400 g of sodium bicarbonate and water at a temperature below 20 & lt; 0 & gt; C 750 g of the dubbed solution, extracted twice with ethyl acetate, 800 g each time; The organic phases were combined, washed with water, dried over anhydrous sodium sulfate and concentrated. The concentrate was crystallized from a mixed solvent of ethyl acetate / isooctane (720 g / 830 g) to give 169 g of the title compound.

Statistics shows that 274693-26-4 is playing an increasingly important role. we look forward to future research findings about 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol.

Reference:
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Li Xuechao; Luo Jie; Xiang Zhixiang; Yuan Daoyi; (24 pag.)CN103664958; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 355806-00-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 355806-00-7, name is (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl) methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester. A new synthetic method of this compound is introduced below.

In a three-necked flask with a condenser, rosuvastatin tert-butyl ester 50.0g, 12.0g (+/-) – phenethylamine and 130ml toluene, stirring for reaction at 100 ~ 110 degrees for about 12 hours, the reaction was complete after HPLC detection of raw materials, slightly cooled, was added 80ml of water, rhoEta = 5 with concentrated hydrochloric acid, points to the water layer, the oil layer was concentrated to dryness to give a reddish brown oil. In the above oil Added 250ml methyl tert-butyl ether, warmed to a clear, refluxed 10min, naturally cooled to 25-30 C, a large amount of white solid Precipitation, stirring crystallization 2h, filtered and dried, weighed 49.5g, a yield of 91.0% by liquid detection, the corresponding isomer is 0.18%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,355806-00-7, its application will become more common.

Reference:
Patent; Zhejiang Jingxin Pharmaceutical Co., Ltd.; Shangyu Jing Xin Pharmaceutical Co., Ltd.; Zhu Jianrong; Zhong Hongban; Zhang Zhongliang; Wang Faping; Chen Jianyang; (8 pag.)CN104529908; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 355806-00-7, (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl) methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 355806-00-7, blongs to pyrimidines compound. Recommanded Product: 355806-00-7

Example 1; Preparation of rosuvastatin calcium salt via rosuvastatin sodium salt solution; Rosuvastatin te/f-butyl ester (60.0 g, 111.6 mmol) is dissolved in 500 mL of a 4:1 mixture of THF / water. The clear solution is warmed to 30 0C and 8.0 M NaOH (15 mL, 120.0 mmol) is added portionwise. The reaction mixture is stirred at 30 X for 2 hours giving a clear yellow solution. Then THF is removed completely under the reduced pressure (20 mbar) at 40 0C. The remaining aqueous solution is diluted with water to 500 mL and washed with AcOEt (2*200 mL). After separation from the organic layer aqueous phase is distilled under the reduced pressure (20 mbar) at 40 0C to completely remove the dissolved AcOEt. The remaining clear solution of sodium rosuvastatinate (440 mL) is diluted with water (60 mL) to 500 mL and warmed to 40 0C. To a vigorously stirring solution of sodium rosuvastatinate is added dropwise Ca(OAc)2chiH2theta (14.8 g, 84.0 mmol in 60 mL of water) over 5 minutes at 40 0C to precipitate rosuvastatin calcium. After the complete addition the suspension is stirred further for 30 minutes at 40 0C. The white precipitate is filtered off. Then a wet white solid is suspended in water (200 mL) and vigorously stirred for 1 hour at 20 0C. The undissolved precipitate is collected by filtration, washed with water (200 mL) and dried in vacuum at 40 0C to give 48.5 g (86.8 %) of rosuvastatin calcium salt as white powder (HPLC: 99.87 %).; Example 2; Rosuvastatin terf-butyl ester (60.0 g, 111.6 mmol) is dissolved in 120 mL of tetrahydrofuran (THF) and 300 ml of water treated 8.0 M NaOH (21 mL) is added portionwise. The reaction mixture is stirred at 5O0C for 2 hours. Reaction mixture is allowed to cool to room temperature and washed with 2 x 540 ml of methylcyclohexane. EPO Aqueous phase is evaporated at 600C under reduced pressure to 220 ml of total volume to eliminate organic solvents. The residue obtained is rediluted with degassed demi-water to 440 ml of total volume. To the resulting solution 1.0 g of charcoal is added and the suspension is stirred half an hour. Charcoal is filtered off. One half of the volume of the filtrate (220 ml of total 440 ml) 25.5 ml aqueous solution of calcium chloride (prepared from 10.5 ml 4M calcium chloride and 15 ml demi- water) is added during stirring on ice-bath. The suspension formed is treated vigorously with ultraturrax at cca 18000 rpm for 3 minutes. The precipitate is filtered off, suspended anew in 100 ml demi water and treated again with Ultraturax at 18000 rpm for 3 minutes on ice-bath. The product is separated by filtration, washed with 30 ml ice-cold degassed demi-water, collected from the filter and dried 12 hours at 500C in vacuum desiccator.Yield: 25.05 g of amorphous rosuvastatin calcium (99.75% area, HPLC, 0.085 % Na)The second aliquot of 220 ml of filtrate is treated on the same way except mechanical stirring instead of ultraturax mixing is performed. Yield 25.11 g (99.72% area, HPLC, 1.55 % Na); Example 3; Rosuvastatin fe/f-butyl ester (10.0 g) is dissolved in 20 mL of tetrahydrofuran and 50 ml of water treated 8.0 M NaOH (3.51 mL) is added portionwise. The reaction mixture is stirred at 500C for 1 hours. One third (26 ml of the total 78 ml) of the resulting solution is washed with 35 ml methylcyclohexane. Methylcyclohexane phase is extracted with 3 ml demi water. Combined aqueous phases are washed with 20 ml /so-propyl acetate. Aqueous phase is then concentrated by evaporation under reduced pressure at 50C to 15 – 20 ml of total volume. It is cooled on ice-bath and gradually 1.1 ml aqueous solution of 4M calcium chloride is added within a minute during stirring. It is stirred additional 30 minutes on ice-bath and the precipitated product is separated by filtration. The precipitate is washed with 4.0 ml demi water, EPO collected from the filter and dried at room temperature 12 hours in vacuum desiccator.Yield: 2.22 g of amorphous rosuvastatin calcium.Two further aliquots are washed with 20 ml ethyl acetate or 20 ml terf-butyl methyl ether respectively with similar yield and quality.; Example 4; Preparation of rosuvastatin sodium salt; Rosuvastatin fe/-butyl ester (3.0 g, 5.6 mmol) is dissolved in 25 mL of a 4:1 mixture of THF / water. The clear solution is warmed to 30 0C and 8.0 M NaOH (0.75 mL, 6.0 mmol) was added portionwise. The reaction mixture is stirred at 30 0C for 2 hours giving a clear yellow solution. Then THF is removed completely under the reduced pressure (20 mbar) at 40 0C. The remaining aqueous solution is diluted with water to 25 mL and washed with AcOEt (2×10 mL). After separation from the organic layer aqueous phase is distilled under the reduced pressure (20 mbar) at 40 0C to completely remove the dissolved AcOEt. The remaining clear solution of sodium rosuvastatinate is diluted with water to 25 mL and liophylized to afford 2.81 g (100 %) of rosuvastatin sodium salt as white powder.; Example 8; Preparation of solid rosuva…

At the same time, in my other blogs, there are other synthetic methods of this type of compound,355806-00-7, (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl) methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester, and friends who are interested can also refer to it.

Reference:
Patent; LEK PHARMACEUTICALS D.D.; WO2006/136408; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia