Tag: M.W=500-600

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Paxhia, Michael D., once mentioned the application of 274693-26-4, Name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol, molecular formula is C26H32F2N6O4S, molecular weight is 562.63, MDL number is MFCD23160137, category is pyrimidines. Now introduce a scientific discovery about this category, COA of Formula: C26H32F2N6O4S.

Functional characterization of the HMP-P synthase of Legionella pneumophila (Lpg1565)

The production of the pyrimidine moiety in thiamine synthesis, 2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate (HMP-P), has been described to proceed through the Thi5-dependent pathway in Saccharomyces cerevisiae and other yeast. Previous work found that ScThi5 functioned poorly in a heterologous context. Here we report a bacterial ortholog to the yeast HMP-P synthase (Thi5) was necessary for HMP synthesis in Legionella pneumophila. Unlike ScThi5, LpThi5 functioned in vivo in Salmonella enterica under multiple growth conditions. The protein LpThi5 is a dimer that binds pyridoxal-5 ‘-phosphate (PLP), apparently without a solvent-exposed Schiff base. A small percentage of LpThi5 protein co-purifies with a bound molecule that can be converted to HMP. Analysis of variant proteins both in vivo and in vitro confirmed that residues in sequence motifs conserved across bacterial and eukaryotic orthologs modulate the function of LpThi5. Importance Thiamine is an essential vitamin for the vast majority of organisms. There are multiple strategies to synthesize and salvage this vitamin. The predominant pathway for synthesis of the pyrimidine moiety of thiamine involves the Fe-S cluster protein ThiC. An alternative pathway utilizes Thi5, a novel enzyme that uses PLP as a substrate. The Thi5-dependent pathway is poorly characterized in yeast and has not been characterized in Bacteria. Here we demonstrate that a Thi5-dependent pathway is necessary for thiamine biosynthesis in Legionella pneumophila and provide biochemical data to extend knowledge of the Thi5 enzyme, the corresponding biosynthetic pathway, and the role of metabolic network architecture in optimizing its function.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , SDS of cas: 274693-26-4, 274693-26-4, Name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol, molecular formula is C26H32F2N6O4S, belongs to pyrimidines compound. In a document, author is Yamazaki, Takashi, introduce the new discover.

Facile preparation and conversion of 4,4,4-trifluorobut-2-yn-1-ones to aromatic and heteroaromatic compounds

The concise preparation of 4,4,4-trifluorobut-2-yn-1-ones by the oxidation of the readily accessible corresponding propargylic alcohols as well as their utilization as Michael acceptors for the construction of aromatic and heteroaromatic compounds are reported.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 274693-26-4. SDS of cas: 274693-26-4.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 274693-26-4, Name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol, SMILES is CC1(C)O[C@]([C@H](N2N=NC3=C(N[C@H]4[C@H](C5=CC=C(F)C(F)=C5)C4)N=C(SCCC)N=C32)C[C@@H]6OCCO)([H])[C@]6([H])O1, in an article , author is Ahmed, Eman A., once mentioned of 274693-26-4, Computed Properties of C26H32F2N6O4S.

Boosting the catalytic performance of zinc linked amino acid complex as an eco-friendly for synthesis of novel pyrimidines in aqueous medium

Zinc linked amino acid complex, Zn(l-proline)(2), is considered as a green catalyst for the synthesis of novel series of pyrimidine derivatives 5a-q. The pyrimidines 5a-q were prepared via two pathways: the first is a one-pot reaction of guanidines 3(a-c) with aromatic aldehyde 1 and acetophenones 2; and the second one is the reaction of guanidines 3(a-c) with different chalcones 4(a-j) in aqueous medium. The simplicity of the operation, the short reaction time, and the high efficiency (97%) are the main advantages of this protocol. Furthermore, the green aspects of this synthetic protocol were further investigated by examining the reusability of Zn(l-proline)(2) complex throughout five consecutive cycles without a significant loss of catalytic activity. This new procedure has presented remarkable advantages in terms of safety, simplicity, stability, mild conditions, a short reaction time, excellent yields, and high purities without using any organic solvents.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 274693-26-4, you can contact me at any time and look forward to more communication. Computed Properties of C26H32F2N6O4S.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 274693-26-4, Name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol, molecular formula is C26H32F2N6O4S. In an article, author is Zhang, Guojie,once mentioned of 274693-26-4, Category: pyrimidines.

A high density and insensitive fused [1,2,3]triazolo-pyrimidine energetic material

A novel fused triazolo-pyrimidine energetic compound was synthesized by the two-step diazotization-nitrification method or one-step direct nitration reaction. The physical properties and detonation properties of intermediate 3H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-diamine (2) and N-(7-oxo-6,7-dihydro-2H-[1,2,3]triazolo[4,5d]pyrimidin-5-yl)nitramide (3) were further explored. Compound 2 has a higher decomposition temperature (368 degrees C) than that of 2,4,6-trinitrotoluene (TNT, 295 degrees C). X-ray crystal-structure analysis shows that the density of compound 3 was 1.97 g cm(-3) at 100 K. Not only the detonation performance of compound 3 (8845 m s(-1), 32.54 GPa) was predicted to approach RDX (8795 m s(-1), 34.9 GPa) but displays significantly good safety properties (36 J), which means that compound 3 may serve as a potential high energy insensitivity material (HEIM).

Interested yet? Keep reading other articles of 274693-26-4, you can contact me at any time and look forward to more communication. Category: pyrimidines.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , HPLC of Formula: C26H32F2N6O4S, 274693-26-4, Name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol, molecular formula is C26H32F2N6O4S, belongs to pyrimidines compound. In a document, author is Liu, Rui-Xue, introduce the new discover.

The copper(II) complexes of new anthrahydrazone ligands: In vitro and in vivo antitumor activity and structure-activity relationship

Two new copper(II) complexes, 9-PMAH-Cu (1) and 9-FPMAH-Cu (2), of anthrahydrazone were synthesized and structurally characterized, in which 9-FPMAH (9-(4′-trifluoromethyl)-pyrimidine anthrahydrazone) is the 4′-CF3 derivative of 9-PMAH (9-pyrimidine anthrahydrazone). Both complexes 1 and 2 showed similar intercalative binding modes towards DNA and might compete with the typical DNA intercalator, GelRed, in the same binding site. They could also act as topoisomerase (type I) suppressor to effectively inhibit its activity, in which complex 1 was more effective than 2. The in vitro antitumor screening indicated that complex 1 displayed much higher antiproliferative ability than 2 and cisplatin towards all the tested tumor cell lines. On the other hand, complex 1 also showed high cytotoxicity against human normal liver cell line HL-7702, suggesting it is a potential high cytotoxic antitumor candidate. While it was also suggested that the loss of activity of complex 2 might be due to the presence of 4′-CF3 on the pyrimidine ring. Studies on the cellular level showed that complex 1 could arrest the cell cycle of the most sensitive T-24 cells at G2/M phase and induced cell apoptosis. Complex 1 further showed a significant suppression on the tumor growth on the T-24 tumor xenograft mouse model, but not reduced the body weight. Especially, complex 1 could retain its coordination state in H2O even in the presence of HSA. The results suggests that complex 1 is of enough safety to be considered as a promising anticancer candidate by combining the bioactive Cu(II) and the anthrahydrazone pharmacophore.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 274693-26-4. HPLC of Formula: C26H32F2N6O4S.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 274693-26-4, Name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol. In a document, author is Khoshniazi, Hamideh, introducing its new discovery. COA of Formula: C26H32F2N6O4S.

Synthesis and antiproliferative assessments of new derivatives of isothiazolo[3,4-d]pyrimidine

Various derivatives of 5-aryl-4-imino-3-(phenylamino)-4,5-dihydroisothiazolo[3,4-d]pyrimidines (3a-f) were synthesized. The synthesis has been done through treatment of 3-amino-4-cyano-5-(phenylamino)isothiazole with various aryl isothiocyanates. The isothiazole skeleton was obtained by the reaction of malononitrile and phenyl isothiocyanate followed by chloramine treatment. Some of the synthesized dihydroisothiazolo[3,4-d]pyrimidines were tested against different cancer cell lines, including ACHN, HeLa, HL-60, MCF-7, and PC3. Malignant cells were cultured in RPMI medium and incubated with different concentrations of the mentioned compounds. Cell viability was assessed using the MTS assay. The cytotoxicities of the synthesized compounds are not significant and are probably safe for other biological use.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 274693-26-4 help many people in the next few years. COA of Formula: C26H32F2N6O4S.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Obydennov, Dmitrii L., once mentioned the application of 274693-26-4, Name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol, molecular formula is C26H32F2N6O4S, molecular weight is 562.63, MDL number is MFCD23160137, category is pyrimidines. Now introduce a scientific discovery about this category, Recommanded Product: 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol.

Acyclic Enaminodiones in the Synthesis of Heterocyclic Compounds

This review examines current trends in the use of readily accessible acyclic enaminodiones in the synthesis of heterocyclic structures, including medicinal and natural compounds. Enaminodiones are latent tricarbonyl compounds, therefore their synthetic use exploits mainly their electrophilic properties. In addition, they can act as C-nucleophiles and participate in formal (4+2) cycloaddition reactions as ambiphilic reagents, as well as key intermediates in intramolecular cyclizations. The review analyzes the literature published in 2012-2019; the systematization is based on the structure of the formed heterocycle. The bibliography of the review includes 97 sources.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 274693-26-4, Recommanded Product: 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C26H32F2N6O4S, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 274693-26-4, Name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol, molecular formula is C26H32F2N6O4S. In an article, author is Maligres, Peter E.,once mentioned of 274693-26-4.

Synthesis of Fused Oxepane HIV Integrase Inhibitor MK-1376

Controlling the absolute and relative stereochemistry of a seven-membered oxepane in the formation of HIV integrase inhibitor MK-1376 was accomplished through a strategy involving the use of asymmetric allylation and stereoconvergent, substrate-directed installation of an amine fragment. Surprising reactivity was demonstrated during the asymmetric allylation in which the allyl-pyrimidone product was formed reversibly. The stereoconvergent amine addition was accomplished through an elimination/addition sequence involving a quinone methide reactive intermediate, and nucleophilic trapping of the reactive quinone methide intermediate with methylamine. This novel approach delivered MK-1376, offering 100-fold greater productivity and 50-fold less waste than the initial synthetic chemistry route.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Related Products of 289042-12-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, molecular formula is C29H40FN3O6S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 3 L four-necked flask was added 1.5 L of absolute ethanol and 128.0 g of 6 – [(1E) -2- [4- (4-fluorophenyl) -6-isopropylYl-2- [methyl (methylsulfonyl) amino] -5-pyrimidine] vinyl] -2,3-dimethyl-1,3-dioxacyclohexane-4-acetic acid tert-butyl ester(Compound III). After stirring, 450 g of dilute hydrochloric acid solution with a mass fraction of 3.6% was added dropwise, stirred at room temperature for 4 to 6 hours, and TLC was monitored until compound III disappeared. After completion of the reaction, 320 g of a sodium hydroxide solution having a mass fraction of 4% was added dropwise to the reaction system and stirring was continued for 4 to 6 hours. The reaction was continued until the first stage of the dihydroxy ester intermediate was completely disappeared (residual?0.5%). The ethanol was then concentrated under reduced pressure, and then 2 L of purified water was added to the system. After stirring, the mixture was extracted twice with methyl t-butyl ether and the aqueous phase was concentrated to no organic solvent residue. The mass fraction was then slowly added to the resulting aqueous solution For 10% of the calcium acetate solution 420g, a white solid precipitation, after the drop is completed, continue stirring 4 to 6 hours, filtration, filter cake with 2L purified water beating 1 times, dry, filter cake vacuum drying, Statin calcium A, the yield was 87.0%, content ? 99.0%, purity(HPLC) ?99.0%, single maximum impurity ? 0.5%, product ee value ? 99.9%.

According to the analysis of related databases, 289042-12-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Anhui Mei Nuohua Pharmaceutical Chemical Co., Ltd.; Shi Jianxiang; Pan Qijiao; Ding Maohua; Gong Daoxin; Zhu Guosheng; (14 pag.)CN106674281; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 289042-12-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, molecular formula is C29H40FN3O6S, molecular weight is 577.71, as common compound, the synthetic route is as follows.

A mixture of BEM (5.0 g) and acetonitrile (35 ml) was stirred under an inert atmosphere at 40 C. 0.02M hydrochloric acid (9.5 ml) was added over 30 minutes to the resultant solution, maintaining the temperature at 35 C. to 42 C. The mixture was stirred at 40 C. for 3 hours then cooled to 25 C. 1.0M sodium hydroxide solution (9.5 ml) was added with stirring at 25 C. and the mixture was stirred for an additional one hour at 25 C. Sodium chloride (4.7 g) was added and the mixture was cooled to -5 C. over one hour. Sufficient of a solution of 1M hydrochloric acid (9.5 ml) and sodium chloride (2.4 g) was added at -5 C. to achieve a pH of 3.4 to 4.0 and the mixture stirred at this temperature for 5 minutes. The mixture was allowed to settle for 10 minutes at -5 C. to give two layers. The lower layer was separated and discarded. Acetonitrile (65 ml) at -5 C. was added to the remaining solution and the mixture was filtered through a filter agent. 40% methylamine solution in water (1.1 ml) was added at -5 C. and the mixture was warmed to 30 C. over 40 minutes and maintained at this temperature for 90 minutes. The mixture was then cooled to 0 C. over 40 minutes and maintained at this temperature for 90 minutes. The resultant solid was collected by filtration and washed with acetonitrile (2¡Á12 ml). The solid, which is the methylamine salt of the compound of formula IV (R1=MeNH3+), was dried under vacuum at 35 C. (3.87 g). 8% w/w aqueous sodium hydroxide (5.44 ml) was added to a stirred mixture of the methylamine salt (6.0 g) in degassed water (30 ml) at 20 C. and the mixture was stirred for one hour. The mixture was filtered and concentrated under reduced pressure at 40 C. until 24 ml of distillate collected. Water (24 ml) was added and the mixture again concentrated under reduced pressure at 40 C. until 24 ml of distillate collected. Water (30 ml) was added and a solution of calcium chloride dihydrate (1.03 g) in water (6 ml) was added dropwise at 20 C. The mixture was stirred for 45 minutes and the resultant solid filtered. The solid was washed with water (36 ml) and dried under vacuum at 40 C. to give the calcium salt of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid.

Statistics shows that 289042-12-2 is playing an increasingly important role. we look forward to future research findings about tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate.

Reference:
Patent; Butters, Michael; Lenger, Steven Robert; Murray, Paul Michael; Snape, Evan William; US2008/207903; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia