Tag: M.W=500-600

289042-12-2, Adding some certain compound to certain chemical reactions, such as: 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate,molecular formula is C29H40FN3O6S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 289042-12-2.

Preparation of LDA: To a 500 mL three-necked flask was added 5.75 g of diisopropylamine and 180 mL of THF, three times with nitrogen, nitrogenGas protection, the temperature to -25 (internal temperature), slowly dropping n-BuLi, keep the internal temperature is not higher than -20 , after the dropTo -10 C, continue stirring for 30min, that is, LDA.A solution of ROS01 (10 g) in tetrahydrofuran (50 mL) was cooled to below -70 C, and freshly prepared bisSolution of lithium isopropylamide in tetrahydrofuran was added dropwise. After stirring for 30 min, 1.6 mL of acetone was slowly added dropwise.60min after the addition of 10mL of acetone, reaction 30min, then add 5mL of acetone, the reaction is completed, add 80mL saturated ammonium chlorideThe solution was quenched, separated, and the tetrahydrofuran phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, evaporated to dryness,The crude product was purified by column chromatography (ethyl acetate: petroleum ether = 4: 1) to give the title compound, 4.93 g, 45% yield.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 289042-12-2.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Zhang Zhenfeng; Chen Zhijun; Liu Daobo; Li Dasheng; (8 pag.)CN104557885; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 208465-21-8, name is Mesosulfuron-methyl. This compound has unique chemical properties. The synthetic route is as follows. 208465-21-8

Example 25 – 1-(4,6-Dimethoxypyrimidin-2-yl)-3-[2-(hydroxymethyl)-5- (methanesulfonamidomethyl henyl]sulfonyl-urea 8 To a solution of methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoyl]-4- (methanesulfonamidomethyl)benzoate (2 g, 3.98 mmol) in THF (30 mL) was added lithium aluminium hydride (755 mg, 19.88 mmol), portionwise, at -20 C. The reaction mixture was warmed to ambient temperature over 1 h, after which time TLC showed complete consumption of the starting material. The reaction was quenched with IPA (5 mL), MeOH (5 mL) and H20 and then acidified to pH 3 with 2 M HCI before being extracted with EtOAc, the organic layer dried over MgS04 and the solvent removed in vacuo. The resulting product was purified by flash chromatography on silica gel (solvent EtOAc) to afford the desired product as a white solid (1.12 g, 59%). 1 H NMR deltaEta (CDCIs, 300 MHz): 9.11 (s, 1 H), 7.90 (s, 1 H), 7.53 – 7.51 (m, 1 H), 7.40 – 7.38 (m, 1 H), 7.24 – 7.20 (m, 1 H), 5.51 (s, 1 H), 4.75 (s, 2H), 4.06 (d, J = 6.0 Hz, 2H), 3.70 (s, 6H), 2.60 (br, 2 H), 2.56, (s 3H). ESI-MS 476.1 [MH]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,208465-21-8, Mesosulfuron-methyl, and friends who are interested can also refer to it.

Reference:
Patent; REDX PHARMA LIMITED; THOMPSON, William; JACKSON, Peter; LINDSAY, Derek; SCREEN, Thomas; MOLTON, Benjamin; URCH, Christopher; WO2013/136073; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia