Takahashi, Bitoku; Ohta, Kiminori; Kawachi, Emiko; Fukasawa, Hiroshi; Hashimoto, Yuichi; Kagechika, Hiroyuki published the artcile< Novel Retinoid X Receptor Antagonists: Specific Inhibition of Retinoid Synergism in RXR-RAR Heterodimer Actions>, Related Products of 89793-12-4, the main research area is retinoid X receptor antagonist preparation cell differentiation obesity diabetes; pyrimidinecarboxylate RXR antagonist cell differentiation obesity diabetes.
Several 2-(arylamino)pyrimidine-5-carboxylic acids were designed as novel retinoid X receptor (RXR) antagonists. Two of the tested compounds alone did not exhibit differentiation-inducing activity toward HL-60 cells and did not affect the activity of a retinoic acid receptor (RAR) agonist, Am80, but did inhibit the synergistic activity of an RXR agonist, PA024, in the presence of Am80. The activity of these compounds was ascribed to selective antagonism at the RXR site of RXR-RAR heterodimers.
Journal of Medicinal Chemistry published new progress about Acute promyelocytic leukemia. 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, Related Products of 89793-12-4.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia