Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Name: 2,4-Dichloro-5-fluoropyrimidine.
Tamizharasan, Natarajan;Gajendran, Chandru;Kristam, Rajendra;Sulochana, Suresh P.;Sivanandhan, Dhanalakshmi;Mullangi, Ramesh;Mathivathanan, Logesh;Hallur, Gurulingappa;Suresh, Palaniswamy research published 《 Discovery and optimization of novel phenyldiazepine and pyridodiazepine based Aurora kinase inhibitors》, the research content is summarized as follows. The synthesis and evaluation of phenyl/pyridine diazepine analogs I [R1 = piperazin-1-yl, morpholino, 4-methylpiperazin-1-yl, 4-acetylpiperazin-1-yl], II [R2 = 1-methylpyrazol-3-yl, 4-carboxyphenyl, 4-(4-methylpiperazin-1-yl)phenyl, etc.] and III [R3 = 1-methylpyrazol-3-yl, 4-sulfamoylphenyl, 4-morpholinophenyl, etc.] was described. The diazepane aniline pyrimidine I [R1 = 4-methylpiperazin-1-yl] was identified as an initial hit (Aurora B IC50 6.9μM). Mol. modeling guided SAR optimization lead to the identification of 8-fluorobenzodiazepine III [R3 = 4-sulfamoylphenyl] with single digit nM potency (Aurora B IC50 8 nM). In the antiproliferation assay compound III [R3 = 4-sulfamoylphenyl] showed activity across the cell lines with IC50 of 0.57, 0.42, and 0.69μM for MCF-7, MDA-MB 231 and SkoV3 resp. In the in-vivo PK profile. compound III [R3 = 4-sulfamoylphenyl] was showed higher bioavailability (73%) along with good exposure (AUC of 1360 ng.h/mL).
2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Name: 2,4-Dichloro-5-fluoropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia