On February 16, 2012, Tang, Pengcho; Li, Xin; Wang, Bin; Li, Xiangqin; Chen, Yang; Chen, Xuejiang; Zhang, Lei; Song, Min published a patent.Reference of 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride The title of the patent was Preparation of phthalazinone derivatives useful as antitumor agents. And the patent contained the following:
The invention relates to phthalazinone derivatives (e.g., I), processes for preparing them, pharmaceutically preparations comprising them, and their use as poly (ADP-ribose) polymerase (PARP) inhibitors for treating cancer. For instance, the invention compound I was prepared and gave a PARP-1 inhibition IC50 value of 0.5 nM. The experimental process involved the reaction of 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride(cas: 1187830-46-1).Reference of 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride
The Article related to phthalazinone derivative preparation antitumor parp inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Reference of 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia