Tereshchenkov, A. G. published the artcileInteraction of chloramphenicol tripeptide analogs with ribosomes, HPLC of Formula: 186046-81-1, the publication is Biochemistry (Moscow) (2016), 81(4), 392-400, database is CAplus and MEDLINE.
Chloramphenicol amine peptide derivatives containing tripeptide fragments of regulatory “stop peptides”-MRL, IRA, IWP-were synthesized. The ability of the compounds to form ribosomal complexes was studied by displacement of the fluorescent erythromycin analog from its complex with E. coli ribosomes. It was found that peptide chloramphenicol analogs are able to bind to bacterial ribosomes. The dissociation constants were 4.3-10 μM, which is 100-fold lower than the corresponding values for chloramphenicol amine-ribosome complex. Interaction of the chloramphenicol peptide analogs with ribosomes was simulated by mol. docking, and the most probable contacts of “stop peptide” motifs with the elements of nascent peptide exit tunnel were identified.
Biochemistry (Moscow) published new progress about 186046-81-1. 186046-81-1 belongs to pyrimidines, auxiliary class Pyrimidine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(4-(((benzhydryloxy)carbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetamido)acetic acid, and the molecular formula is C18H34N4O5S, HPLC of Formula: 186046-81-1.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia