Electric Literature of 145783-14-8, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 145783-14-8, Name is 4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine, SMILES is CCCSC1=NC(Cl)=C([N+]([O-])=O)C(Cl)=N1, belongs to pyrimidines compound. In a article, author is Menke, Annika, introduce new discover of the category.
Formation of Cisplatin Adducts with the Epigenetically Relevant Nucleobase 5-Methylcytosine
With about 4 % abundance in the genome 5-methylcytosine (5mC) is one of the most important epigenetic modifications. Change in DNA hypermethylation levels has even been linked to resistances to cisplatin treatment of cancer cells. This work aimed at the synthesis and full characterization of 5mC-cisplatin adducts as well as for the examination of possible side-reactions and transformations. We report the first X-ray crystal structure of a cis-[PtCl(5mC)(NH3)(2)]Cl complex and the formation of [PtCl(5mC)(NH3)(2)](+) and [PtCl(5mC)(2)(NH3)](+) with HR-ESI mass spectrometry. Further, we explore complex formation and dynamics using H-1, Pt-195, and DOSY NMR spectroscopy. UV/Vis absorption and EPR spectroscopy also confirmed the formation of trace amounts of paramagnetic Pt-blue species. In the process, a hemiprotonated 5mC dimer, 5mC-5mCH(+), reminiscent of the i-motif in DNA tetramers, was structurally characterized.
Electric Literature of 145783-14-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 145783-14-8.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia