Khan, M. Akram; Miller, Keith; Rainsford, Kim Drummond; Zhou, Yong published the article 《Synthesis and antimicrobial activity of novel substituted ethyl 2-(quinolin-4-yl)-propanoates》. Keywords: quinolinylpropanoate preparation antimicrobial Helicobacter.They researched the compound: 4-Chloro-8-methylquinoline( cas:18436-73-2 ).Synthetic Route of C10H8ClN. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:18436-73-2) here.
4-Hydroxyquinolines were synthesized from anilines and EtOCH:C(CO2Et)2 by Gould-Jacobs reaction via cyclization of the intermediate (anilinomethylene)malonate followed by hydrolysis and decarboxylation. The 4-hydroxyquinolines reacted with POCl3 to form 4-chloroquinolines, which reacted on heating with Na+MeC-(CO2Et)2 in DMF to yield moderate yields of 2-(quinolin-4-yl)propanoates, many of which showed potent antimicrobial activity against Helicobacter pylori.
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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia