The important role of 109-12-6

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109-12-6, Pyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.

109-12-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-12-6, name is Pyrimidin-2-amine, molecular formula is C4H5N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(1), weighing 1.008g 2-amino pyrimidine (10.6mmol), 1.480g chloro acetyl chloride (13.1mmol), 1.779g potassium carbonate (12.9mmol) and 13 ml dichloromethane;(2), will step one (1) weighed in 2-amino pyrimidine, potassium carbonate and two-thirds the volume of dichloromethane (about 9 ml) with nitrogen protection device is of the three-port flask, in 0 C under the condition of stirring to dissolve;(3), will step one (1) weighed chloroacetic chloride in and the remaining dichloromethane (about 4 ml) in the constant voltage dropping funnel, then with a constant acceleration of 0.25 ml/min into the three-port flask, 20 min the completion of the dropping, the continued after dropping 0 C stirring reaction under the conditions of 3h, obtaining a reaction product;(4), using vacuum filtration device, step a (3) in the obtained after filtering the reaction product is the reaction product of in addition to the solvent, each with 10 ml deionized water washing the product, washing a total of 5 times, at a temperature of 45 C the product under the conditions of drying, drying time is 5h, the lime-green powdery solid, lime-green powdery solid is acetyl-2-amino pyrimidine, weighing mass is 1.550g, yield 85.22%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109-12-6, Pyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Qiqihar University; Wang, Liyan; Liu, Shifu; Tian, Ying; He, Xianyou; Zhang, Hui; (10 pag.)CN105906572; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia