With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.113583-35-0, name is 2-Methanesulfonyl-4,6-dimethoxypyrimidine, molecular formula is C7H10N2O4S, molecular weight is 218.23, as common compound, the synthetic route is as follows.113583-35-0
0.48 g (2.66 mmol) of 2-mercapto-5-fluorobenzoic acid was added.2-methanesulfonyl-4,6-dimethoxypyrimidine 0.87g(4.0 mmol), 0.1 g (0.3 mmol) of tetrabutylammonium bromide in 95% ethanol,The reaction was refluxed for 15 h, and the pH was measured every two hours.Adjust the pH with a saturated aqueous solution of NaHCO3,The pH of the reaction system was maintained at 7 or higher.Post-reaction treatment: spin the reaction system,Extracted three times with NaOH aqueous solution and ethyl acetate,Extract the water layer and adjust the pH to 3-4 with HCl.At this point the aqueous solution turned into a milky white suspension.The aqueous layer was then extracted with ethyl acetate.Add silica gel and spin over the column.The column was passed through a 80:1 (dichloromethane:methanol) eluent.The product was obtained in 0.15 g.The yield was 18%.
Statistics shows that 113583-35-0 is playing an increasingly important role. we look forward to future research findings about 2-Methanesulfonyl-4,6-dimethoxypyrimidine.
Reference:
Patent; Nankai University; Wang Jianguo; Song Guoqing; Wu Renjun; (25 pag.)CN109111405; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
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