130049-82-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 130049-82-0, name is 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one. This compound has unique chemical properties. The synthetic route is as follows.
Example 3 Preparation of Compound of Formula (I) PaliperidoneIn a three necked flask acetonitrile (230 ml), compound (IV) (20 g) and compound (VI) (23.3 g) were charged. To the reaction mass, potassium carbonate (18 g) and potassium iodide (0.5 g) were added. The contents were heated to 76-78 C. and maintained for 3 hours at 76-78 C. After completion of reaction, the reaction mixture was cooled to 0-5 C. and stirred for 1 hour. The solid, was filtered, washed with water (65 ml). The solid obtained was dissolved in methanol (190 ml) by heating the contents to 60-65 C., treated with activated charcoal (3.5 gm), stirred at 60-65 C. for 30 minutes. The reaction mass was filtered hot over hyflo at 60-65 C., washed with hot methanol (20 ml). Methanol was distilled completely under vacuum below 45 C. to obtain residue. Ethyl acetate (20 ml) was charged and continued distillation under vacuum to remove traces of methanol. The residue was stirred in (20 ml) ethyl acetate for 1 hour at 25-30 C. The resulting solid was filtered and washed with ethyl acetate (10 ml) and dried under vacuum at 40-45 C. for 6 hours to yield 6.5 g of paliperidone. (HPLC purity-99.5%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130049-82-0, 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one.
Reference:
Patent; CIPLA LIMITED; US2010/298565; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia