Related Products of 146533-41-7 ,Some common heterocyclic compound, 146533-41-7, molecular formula is C10H5BrCl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Add 10.0g of V-1 and 80ml of ethylene glycol dimethyl ether to a single-mouth bottle.6.9 g of ethylene glycol and 14.6 g of potassium t-butoxide were added, and the reaction was stirred under reflux for 15 hours.After the reaction is completed, it is cooled to room temperature.The filtrate was poured into 500 ml of 10% citric acid aqueous solution and stirred for 4 h, and suction filtered.The filter cake was placed in a blast to give 8.1 g of the intermediate.The above solid was added to 48 ml of methanol, and the mixture was refluxed until it was dissolved, and the heating was turned off.The temperature was lowered to room temperature, suction filtered, and the filter cake was dried to give a solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 146533-41-7, 5-(4-Bromophenyl)-4,6-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Nanjing Zhengda Tianqing Pharmaceutical Co., Ltd.; Wang Liubo; Wang Zubing; Lin Ping; Wu Jing; Wang Huaping; Chai Yuzhu; Xu Dan; Zhu Chunxia; Tian Zhoushan; (8 pag.)CN108727279; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia