Electric Literature of 157335-93-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 157335-93-8, name is 4,6-Dimethylpyrimidine-5-carboxylic acid, molecular formula is C7H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 110a (51 mg, 0.10 mmol) and DCM (5 mL) was added TFA (1 mL) and the reaction was stirred at RT for 6 h. The solvent was evaporated in vacuo and the residue partitioned between 5M KOH and EtOAc. The phases were separated and the aqueous extracted two times with EtOAc. The combined organic extracts were washed with water and brine, dried (Na2SO4), filtered and evaporated to afford 110b. To a solution of 110b (17 mg, 0.04 mmol), 4,6-dimethylpiperidine-5 carboxylic acid (7 mg, 0.044 mmol), HOBt (7 mg, 0.052 mmol) and DMF (0.5 mL) was added EDCI (10 mg, 0.052 mmol) followed by DIPEA (21 mul, 0.12 mmol). The reaction was stirred at RT for 18 h. The reaction was quenched with water and diluted with EtOAc. The phases were separated and the aqueous extracted two times with EtOAc. The combined EtOAc extracts were dried (Na2SO4), filtered and evaporated. The crude material was purified by Prep HPLC to give 8.1 mg (37%) of IV-13 as a white solid: MS (ESI), m/z 542 (M+H).
According to the analysis of related databases, 157335-93-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Rotstein, David Mark; Melville, Chris Richard; US2008/249087; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia