In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17326-27-1, name is 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde, the common compound, a new synthetic route is introduced below. Recommanded Product: 17326-27-1
G2 (0.5 mmol) was dissolved in 10.4 mL of tert-butyl alcohol and 2.5 mL of 2-methyl-2- butene. A solution of sodium chlorite (4.59 mmol) and sodium dihydrogenphosphate (3.46 mmol) in 4.2 mL of water was added dropwise. The reaction mixture was stirred at room temperature overnight. Volatile components were then removed under vacuum, and the residue was dissolved in 10 ml of water and extracted with two 10 ml portions of hexane. The aqueous layer was acidified to pH=3 with HCl(aq) and extracted with 10 mL portions of methylene chloride. The combined organic layers were washed with 20 mL of cold water, dried and concentrated to give G4.; 2-Chloro-9-methyl-4-oxo-4H-pyrido Gamma 1.2-a1pyrimidine-3 -carboxylic acid ( 144) NMR (400 MHz, OMSO-d6) delta 2.58 (s, 3H), 7.53 (t, J = 7.0 Hz, 1H), 8.14 (d, J = 7.2 Hz, 1H), 8.97 (d. J= 6.8 Hz, 1H), 13.53 (brs, 1H); 13C NMR (100 MHz, DMSO-i/6) delta 16.7, 108.1, 1 17.1, 125.6, 133.3, 138.7, 148.2, 152.0, 154.6, 163.9.
The synthetic route of 17326-27-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INSTITUT PASTEUR KOREA; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (EPST); NO, Zaesung; KIM, Jaeseung; BRODIN, Priscille; SEO, Min Jung; PARK, Eunjung; CECHETTO, Jonathan; JEON, Heekyoung; GENOVESIO, Auguste; LEE, Saeyeon; KANG, Sunhee; EWANN, Fanny, Anne; NAM, Ji, Youn; FENISTEIN, Denis, Philippe, Cedric; CHRISTOPHE, Thierry; CONTRERAS DOMINGUEZ, Monica; KIM, EunHye; HEO, Jamung; WO2011/85990; (2011); A1;,
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