Electric Literature of 1780-33-2, Adding some certain compound to certain chemical reactions, such as: 1780-33-2, name is 4,6-Dichloro-2,5-dimethylpyrimidine,molecular formula is C6H6Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1780-33-2.
Preparation F (6–Chloro-2,5-dimethylpyrimidin-4-yl)-(2,4,6-trimethylphenyl)-acetonitrile To a solution of mesitylacetonitrile (0.900 g, 5.65 mmol) in 8 ml dry THF was added sodium hydride (60percent in oil, 0.250 g, 6.21 mmol) and the mixture was stirred at room temperature for 40 minutes. 2,5-Dimethyl-4,6-dichloropyrimidine (1.000 g, 5.65 mmol) was added and the resulting mixture was heated at reflux for 5 hours. The mixture was quenched with water and extracted with ethyl acetate. The organic layer was dried and concentrated to give 1.800 g of a yellow oil. The oil residue was purified through silica gel column chromatography using 10percent ethyl acetate in hexane as eluent to give 0.986 9 (58.3percent) of the title compound as a white solid, mp 100-102¡ã C. 1 H NMR (CDCl3) delta6.86 (s, 2H), 5.60 (s, 1H), 2.69 (s, 3H), 2.25 (s, 3H), 2.18 (s, 6H), 1.92 (s, 3H) ppm.
According to the analysis of related databases, 1780-33-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Pfizer Inc.; US5962479; (1999); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia