Synthetic Route of 356058-42-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.356058-42-9, name is 2-(2-((4-Fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid, molecular formula is C16H15FN2O3S, molecular weight is 334.3653, as common compound, the synthetic route is as follows.
To an ice cold suspension ofintermediateA4 (2.0 g, 1 equiv) in dichloromethane (15 ml) (wherein a drying tube was used to insulate moisture) were added thionyl chloride (0.47 ml) and DMF (2 drops, catalyst). The mixture was stirred for 0.5 h to get a brown clear solution and then added slowly to a flask containing strong aqua (20 ml) over 10 mm in an ice bath with vigorous stirring. The solid thus formed was collected by filtration, washed to white with water and ethanol, and then dried in vacuo to give the title compound(1.0 g). MS (ESI): 334 (M+H).
Statistics shows that 356058-42-9 is playing an increasingly important role. we look forward to future research findings about 2-(2-((4-Fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid.
Reference:
Patent; Shen, Jianhua; Wang, Yiping; Wang, Kai; US2014/171431; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia