In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16019-33-3, name is 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde, the common compound, a new synthetic route is introduced below. Safety of 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde
4,6-Dichloropyrimidine-5-acetaldehyde 1 (2.0 g, 10.5 mmol) dissolved in 80 mLEthanol, adding triethylamine (3.0 mL,21.06 mmol), stirred at room temperature for 10 min.Then tert-butylamine (2.2 mL, 21.06 mmol) was added to the mixture, and the reaction solution wasAfter stirring at 90 C for 6 h, the reaction was monitored by TLC. After the reaction is completed, after evaporating the solvent,The crude reaction product was dissolved in dichloromethane/water.(volume ratio = 1:1) 100 ml × 3 times.Separation and purification by column chromatography to obtain a white solid1.0 g (yield 55.2%).
The synthetic route of 16019-33-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sichuan University Huaxi Hospital; He Yang; Chai Yingying; Li Weimin; Zhou Xinglong; (20 pag.)CN108794483; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
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