Adding a certain compound to certain chemical reactions, such as: 5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, blongs to pyrimidines compound. Recommanded Product: 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde
4, 6-DICHLORO-2-AMINO-5-FORMYLPYRIMIDINE (1.90 g, 9.89 mmol) and diisopropylethylamine (3.30 ml, 18.95 mmol) were dissolved in anhydrous 1,4-dioxane (25.0 ml). The mixture was stirred on an ice bath and 4-ethyl ester piperidine (1.46 ml, 9.47 mmol) dissolved in dioxane (25.0 ml) was added dropwise. The mixture attained room temperature and after 30 min. the desired product was observed by LCMS m/z 313 (M+H+). The solvent was removed under reduced pressure, and the crude residue dissolved in dioxane (20 ml), to it were added diisopropylethylamine (6,31 ml, 36.22 mmol) and 2-Methyl-5-trifluoromethyl-2H-pyrazol-3- ol (3.95 g, 23.77 mmol). The mixture heated at 90 C for 18 h. Aqueous work up yielded a pale orange solid. Recrystalization from ether and hexanes, followed by filtration of the solid yielded white crystals. Yield 50. 28%,’H NMR 400MHZ DMSO 8 (ppm): 9.90 (s, 1H); 7.42 (d, 2H); 6.76 (s, 1H); 4.09 (M, 2H); 3.95 (d, 2H); 3.76 (s, 3H); 3.09 (M, 2H); 2.63 (M, 1H); 1.90 (M, 2H); 1. 66 (M, 2H); 1.19 (t, 3H). LCMS (ESI) m/z 443 (M+H+, 100 %)
The synthetic route of 5604-46-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARENA PHARMACEUTICALS INC.; WO2004/65380; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia