Related Products of 1194-21-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1194-21-4, name is 2-Amino-6-chloropyrimidin-4(3H)-one, molecular formula is C4H4ClN3O, molecular weight is 145.55, as common compound, the synthetic route is as follows.
6-Amino-4-chloropyrimidin-2(1H)-one (3, 200 mg, 0.84 mmol) and 2-methyl-5-nitroaniline (627 mg, 2.52 mmol) were heated at 170 C for 3 h. The mixture was then cooled to rt and diethyl ether was added. The mixture was sonicated for 5 min. The suspension was filtered, and the filter cake was dissolved in MeOH and purified by column chromatography (silica gel, dichloromethane/methanol 9:1 v/v) to afford 4 (128 mg, 60%) as a brown solid.
Statistics shows that 1194-21-4 is playing an increasingly important role. we look forward to future research findings about 2-Amino-6-chloropyrimidin-4(3H)-one.
Reference:
Article; Kim, Hee Jin; Oh, Chang-Hyun; Yoo, Kyung Ho; Bulletin of the Korean Chemical Society; vol. 34; 8; (2013); p. 2311 – 2316;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia