The important role of 2-Chloro-5-hydroxypyrimidine

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Related Products of 4983-28-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 4983-28-2, Name is 2-Chloro-5-hydroxypyrimidine, SMILES is ClC1=NC=C(C=N1)O, belongs to pyrimidines compound. In a article, author is Savage, Jonathan C., introduce new discover of the category.

A Broccoli aptamer chimera yields a fluorescent K+ sensor spanning physiological concentrations

The RNA aptamer Broccoli accepts 2 ‘ fluorinated (2 ‘ F) pyrimidine nucleotide incorporation without perturbation of structure or fluorescence in the presence of potassium and DFHBI. However, the modification decreases Broccoli’s apparent affinity for K+ >30-fold. A chimera of Broccoli RNAs with mixed chemistries displays linear fluorescent gain spanning physiological K+ concentrations, yielding an effective RNA-based fluorescent K+ sensor.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia