Application of 22536-61-4, Adding some certain compound to certain chemical reactions, such as: 22536-61-4, name is 2-Chloro-5-methylpyrimidine,molecular formula is C5H5ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22536-61-4.
To a 3-neck flask, 5.18 g (40.3 mmol) of 2-chioro- 5-methylpyrimidine, 9.26 g (46.8 mmol) of 3-biphenylboronic acid, 95 ml of 2 M aqueous solution of potassium carbonate, and 70 ml of 1 ,2-dimethoxyethane were added, and after purge with argon gas, 2.25 g (1.95 mmol) of tetrakis (triphenylphosphine) palladium (0) was added and refluxed with heating for 24 hours under argon atmosphere. The reaction solution was cooled to room temperature, the organic layer was then recovered, the solvent was removed by distillation under reduced pressure, and by performing purification using silica gel colunm chromatography (elution solution: dichloromethane), the ligand (L-b) was obtained. The obtained amount was 8.40 g (yield: 84.7percent). Identification of the compound was carried out by using ?H-NMR. The analysis data of the ligand (L-b) are shown below. ?H-NMR (400 MHz/CDC13) oe: 8.66-8.68 (m, 3H),8.39 (d, 1H), 7.70-7.72 (m, 3H), 7.56 (t, 1H), 7.46 (t, 2H),7.37 (t, 1H), 2.36 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 22536-61-4, 2-Chloro-5-methylpyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY; FURUYA METAL CO., LTD.; Konno, Hideo; Sugita, Yoshiro; Ito, Takashi; (104 pag.)US2018/66001; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia