Adding a certain compound to certain chemical reactions, such as: 10320-42-0, 2-Chloro-5-nitropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-Chloro-5-nitropyrimidine, blongs to pyrimidines compound. Application In Synthesis of 2-Chloro-5-nitropyrimidine
a dry 50 ml reaction flask was vacuumed three times with nitrogen, then added 2-tert-butylphenol (150 mg, 1.0 mmol, 1.0 equiv) to the reaction flask, and added 3.0 ml of dried THF. Stir to 2-tert-butylphenol to dissolve, then add NaH (28.8 mg, 1.2 mmol, 1.2 equiv, sodium hydride content 60percent suspended in mineral oil) to the reaction flask under ice bath, under ice bath The reaction was carried out for 30 min; then 2-chloro-5-nitropyrimidine (0.1593 g, 1.0 mmol, 1.0 equiv) was added to the reaction flask. The entire mixture was slowly raised to a temperature of 50 ¡ã C for 12 hours. The reaction was monitored by TLC, and the reaction was stopped if it was detected that all of the phenol was completely reacted. The experimental treatment was to drain the solution in the reaction; dissolve the solute in the reaction flask with ethyl acetate, transfer it to a 100 ml round bottom flask, and add 3 ml (200-300 mesh) of silica gel to the round bottom flask. Dry (petroleum ether and ethyl acetate) over silica gel on the column.The intermediate product was white crystals of 2-(2-(tert-butyl)phenoxy)-5-nitropyrimidine (189 mg, 87percent yield).
The synthetic route of 10320-42-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jinan University; Feng Pengju; Chen Tianfeng; Chen Junfeng; Huang Yifeng; (19 pag.)CN108164397; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia