Synthetic Route of 75833-38-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 75833-38-4, name is 2-Chloropyrimidine-4-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 2-chloropyrirnidine-4-carbonitrile (900 mg, 6.45 mmol) in dioxane (8 mL)/water (2 mL) was added K2C03 (2.20 g, 16.12 mmol), Pd(dppf)Cl2 (1.0 g, 1.29 mmol) and 4,4,5, 5-tetramethyl-2-vinyl-l,3,2-dioxaborolane (1.5 g, 9.67 mmol). The resulting mixture was stirred at 90 C overnight. After cooling to RT, the mixture was diluted with water (10 mL) and extracted with EtOAc (30 mL x 3). The combined organic layers were washed with brine, dried over Na2SC>4, filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography column (9% EtOAc in petroleum ether) to give the title compound as a solid. LRMS m/z (Mu+Eta) 132.1 found, 132.1 required.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 75833-38-4, 2-Chloropyrimidine-4-carbonitrile.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; LIVERTON, Nigel; LUO, Yunfu; (85 pag.)WO2016/100156; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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