The important role of 2-Methylpyrimidine-5-carboxylic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5194-32-1, 2-Methylpyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 5194-32-1, 2-Methylpyrimidine-5-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-Methylpyrimidine-5-carboxylic acid, blongs to pyrimidines compound. Application In Synthesis of 2-Methylpyrimidine-5-carboxylic acid

Example 331 lambda/-{[1 ,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1 H- pyrazoIo[3,4-b]pyridin-5-yl]methyl}-2-methyl-5-pyrimidinecarboxamide2-Methyl-5-pyrimidinecarboxylic acid [e.g. available from Chemstep] (72mg) was dried under vacuum over phosphorous pentoxide for 3 days and was then suspended in dry dichloromethane (1.5ml) and treated at 200C with oxalyl chloride (0.046ml) and DMF (1 drop). Rapid effervescence occurred and the mixture was stirred at room temperature for 30mins and then added dropwise to a solution of Intermediate 16 (143mg) in acetonitrile (3ml). DIPEA (0.093ml) was added and the mixture was stirred at room temperature for 1.75h. The mixture was blown down to dryness and the residue purified by mass directed autoprep HPLC. Relevant fractions were collected and evaporated to dryness. The residue was further purified by SPE cartridge (5g, aminopropyl) eluting with methanol. Relevant fractions were collected and evaporated to dryness. The residue was further purified by preparative TLC on a silica plate (20cm x 20cm x 1 mm) eluting with 5% methanol in ethyl acetate. The major band was collected, extracted with 20% methanol in chloroform and filtered and the filtrate evaporated to give Example 331 (70mg) as a yellow solid. LCMS showed MH+ = 424; TRET = 2.21 min.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5194-32-1, 2-Methylpyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2007/36733; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia