Reference of 213265-83-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine. A new synthetic method of this compound is introduced below.
Intermediate A37-2 (150mg, 0.75mmol) was dissolved in tetrahydrofuran (5mL), was added 4,6-dichloro-5-fluoropyrimidine (126mg, 0.75mmol),Diisopropylethyl amine (292mg, 2.26mmol), 50 stirred overnight, cooled to room temperature, spin dry solvent, the residue was purified by column chromatography (dichloromethane:Methanol = 50: 1) to afford an off-white solid (136mg, 55%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,213265-83-9, 4,6-Dichloro-5-fluoropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Suzhou Yunxuan Pharmaceutical Co., Ltd.; Zhang, Xiaohu; (54 pag.)CN105254613; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia