Electric Literature of 6693-08-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6693-08-9, name is 2,4,6-Trichloro-5-fluoropyrimidine. A new synthetic method of this compound is introduced below.
2,4,6-trichloro-5-fluoropyrimidine (1.54 g, 7.65 mmol),(2S,3S)-3-Aminobicyclo[2.2.2]octane-2-carboxylic acid ethyl ester hydrochloride (1.79 g, 7.65 mmol)And K2CO3 (2.64 g, 19.12 mmol) was suspended in DMF (15 mL).The resulting mixture was stirred at room temperature overnight.The reaction solution was quenched by adding H 2 O (50 mL).Extract with ethyl acetate (50 mL × 3),The combined organic phases were washed with saturated brine (100 mL×3).Dry over anhydrous sodium sulfate, filter, and concentrate the filtrate.The residue was purified by silica gel column chromatography (EtOAc /EtOAcThe title compound was obtained as a pale yellow solid(0.69g, 25%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6693-08-9, 2,4,6-Trichloro-5-fluoropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Yi Kai; Lei Yibo; Wang Yejun; Zhang Yingjun; (138 pag.)CN108276401; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia