The important role of 2,4,6-Trichloropyrimidine-5-carbaldehyde

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 50270-27-4, 2,4,6-Trichloropyrimidine-5-carbaldehyde.

Reference of 50270-27-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50270-27-4, name is 2,4,6-Trichloropyrimidine-5-carbaldehyde, molecular formula is C5HCl3N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of Compound 7A (2.1 14 g, 10 mmol) and sulfanilamide (1.722 g, 10 mmol) in dioxane (80 mL) was stirred in an oil bath at 40-50 0C for 10 minutes, and then at room temperature overnight. The mixture was evaporated in vacuo to give a solid, which was washed with methylene chloride and water; and then dried to give Compound 7B as yellow solid (3.Og, 78percent based on HCI salt). 1H NMR ((CD3)2SO) delta 1 1.1 (s, IH), 10.3 (s, IH), 9.85 (d, 2H), 9.80 (d, 2H), 7.35 (s, 2H); MS 346 (M-I-H+).A mixture of Compound 7B (173.6 mg, 0.5 mmol) and benzyl amine (109.2 uL, 1.0 mmol) in THF (5 mL) was stirred at room temperature overnight. The mixture was evaporated in vacuo and then was subjected to HPLC separation to give Compound 7C as HCl salt (13.1 mg, 5percent based on HCl salt). MS 418 (M+H+), 440 (M+Na+).7C *A mixture of Compound 7C (IO mg, 0.024 mmol) and hydrazine (20 uL) in methanol (1 mL) was refluxed for 30 minutes; and then evaporated to dryness. The residue was washed with water and dried to give Compound 2 as a pale yellow solid (4 mg, 42percent). 1H NMR ((CD3)2SO) delta 8.2 (s, IH), 7.8 (m, 4H), 7.6-7.3 (m, 8H), 4.7 (s, 2H); MS 396 (MH-H+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 50270-27-4, 2,4,6-Trichloropyrimidine-5-carbaldehyde.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/39359; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia