Adding a certain compound to certain chemical reactions, such as: 1032452-86-0, 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1032452-86-0, blongs to pyrimidines compound. Product Details of 1032452-86-0
The compound 3- (2-chloro-4-yl) -1-methyl indole (2.4g, 9.85mmol)And methyl 4-amino-5-methoxy-2-nitrobenzoate (2.67 g, 11.82 mmol)Into the reaction flask,Then 1,4-dioxane (20 mL) was added,p-Toluenesulfonic acid (2.03 g, 11.82 mmol) was added with stirring and the reaction was heated to 85C for 48 hours.After the reaction is completed,Cool to room temperaturePrecipitate solids, filter,The cake was washed with acetonitrile.Dry to give a yellow solid (4.0 g, yield: 93.7%).
The synthetic route of 1032452-86-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tianjin Binjiang Pharmaceutical Research And Development Co., Ltd.; Tian Hongqi; Huang Gongchao; Cheng Ying; (48 pag.)CN107793413; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia