Electric Literature of 330786-24-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 330786-24-8, name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, molecular formula is C17H13N5O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The solution of (S)-1-boc-3-methylsulfonyloxy piperidine (115.5 g) indimethylacetamide (300 ml) was added to the reaction mixture of 3-(4-phenoxyphenyl)- 1 H-pyrazolo[3 ,4-d]pyrimidine-4-amine (50 g), cesium carbonate(13.4 g) and potassium carbonate (108.3 g) in dimethylacetamide (450 ml) at 55C.The reaction mass was heated to 85C, stirred for 14h, filtered and concentrated.The concentrated mass was dissolved in 1:1 mixture of methanol-toluene (1250 ml)and added hydrochloric acid (117 ml; 18% w/v). The reaction mixture was stirredfor 6 h at 45C, separated the aqueous layer and concentrated under vacuum. The concentrated mass was stirred with methanol (100 ml) and ethyl acetate (625 ml), filtered the solid and dried to yield (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl-1H- pyrazolo[3 ,4-d]pyrimidine-4-amine hydrochloride (59 g; 78.4%).HPLC Purity: 99.6%
According to the analysis of related databases, 330786-24-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NATCO PHARMA LIMITED; MUDDASANI, Pullareddy; BUDIDETI, Shankar Reddy; MADALAPU, Veerababu; GATTU, Anitha; KONDA, Bala Ankireddy; NANNAPANENI, Venkaiah Chowdary; (20 pag.)WO2017/134684; (2017); A2;,
Pyrimidine | C4H4N2 – PubChem,
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