With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.36314-98-4, name is 2-Amino-4-cyanopyrimidine, molecular formula is C5H4N4, molecular weight is 120.11, as common compound, the synthetic route is as follows.SDS of cas: 36314-98-4
Intermediate 1-11-4To a solution of 2-aminopyrimidine-4-carbonitrile (1 g, 8.3 mmol) in 7M NH3 in MeOH (25.5 mL) was added Raney-Nickel (50% wet, 1.955 g, 33 mmol) and stirred at RT under an H2 atmosphere (32.5 bar) for 22h. The reaction was filtered and concentrated to give the intermediate 1-11-4 (954 mg, 92%) which was used without further purification.1H-NMR (400 MHz ,DMSO-d6), Shift [ppm]= 3.55 (2H), 6.34-6.54 (2H), 6.63 (1H), 8.09- 8.21 (1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,36314-98-4, 2-Amino-4-cyanopyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; GRAHAM, Keith; KLAR, Ulrich; BRIEM, Hans; HITCHCOCK, Marion; BAeRFACKER, Lars; EIS, Knut; SCHULZE, Volker; SIEMEISTER, Gerhard; BONE, Wilhelm; SCHROeDER, Jens; HOLTON, Simon; LIENAU, Philip; TEMPEL, Rene; SONNENSCHEIN, Helmut; BALINT, Jozsef; GRAUBAUM, Heinz; (577 pag.)WO2015/193339; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia